Axonal damage in multiple sclerosis: a complex issue in a complex disease.

Abstract:

:Multiple sclerosis is no longer considered to simply be an autoimmune demyelinating disease. Axonal destruction is another central pathological feature and a contributor to the accumulating disability of disease progression. The mechanism underlying axonal pathology has not been fully clarified but does not appear to be a simple one. The relationship between axonal damage and other components of the pathological features such as demyelination, inflammation and remyelination are under intense investigation. Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance.

journal_name

Clin Neurol Neurosurg

authors

Grigoriadis N,Ben-Hur T,Karussis D,Milonas I

doi

10.1016/j.clineuro.2004.02.017

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

211-7

issue

3

eissn

0303-8467

issn

1872-6968

pii

S0303846704000435

journal_volume

106

pub_type

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