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Intracardiac QT variability in patients with structural heart disease on class III antiarrhythmic drugs.

Abstract：

:We previously showed that increased intracardiac repolarization lability predicts life-threatening ventricular arrhythmias in patients with structural heart disease. Patients with structural heart disease frequently take antiarrhythmic drugs (AADs), which directly affect repolarization. The effect of AADs on the predictive value of repolarization lability is unknown. We hypothesized that increased intracardiac beat-to-beat QT variability predicts sustained ventricular tachyarrhythmias in structural heart disease patients on class III AADs. Intracardiac electrograms and surface electrocardiogram were simultaneously recorded at rest for 5 minutes in 500 patients (mean +/- SD age, 61 +/- 14 years; 368 male [74%]) with implanted implantable cardioverter-defibrillator for primary (295 patients, or 79%) or secondary prevention of sudden cardiac death. Mean (SD) follow-up currently reached 24.8 (11.7) months. Intracardiac QT variability index was an independent predictor of ventricular tachycardia/ventricular fibrillation events and fast ventricular arrhythmias with cycle length of 240 ms or less in the multivariate Cox model. Intracardiac QT variability was higher in patients on class III AADs than in those not taking these drugs. Increased intracardiac QT variability after adjustment for class III AADs use carried independent risk of life-threatening ventricular tachyarrhythmias.

journal_name

J Electrocardiol

journal_title

Journal of electrocardiology

authors

Tereshchenko LG,Fetics BJ,Berger RD

doi

10.1016/j.jelectrocard.2009.07.011

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

505-10

issue

6

eissn

0022-0736

issn

1532-8430

pii

S0022-0736(09)00323-9

journal_volume

42

pub_type

杂志文章

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