QRS integral: an electrocardiographic indicator of mechanical interventricular asynchrony.

Abstract:

AIM:The aim of this study was to investigate whether interventricular asynchrony (IVA) can be measured by electrocardiography. METHODS:Sixty-two patients (New York Heart Association heart failure functional class III: age, mean +/- SD: 64 +/- 9 years; ejection fraction, mean +/- SD: 24% +/- 8%; dilative cardiomyopathy/ischemic cardiomyopathy, n = 39/23) with left bundle branch block (QRS duration, mean +/- SD: 165 +/- 21 milliseconds) underwent a 120-channel body surface mapping. QRS integral was analyzed and compared with IVA (echo). RESULTS:Interventricular asynchrony was associated with significantly decreased QRS integrals 15 cm cranial and 6 cm lateral from V1 in patients with normal axis (n = 36): At a cutoff value of -26 milliseconds mV, receiver operating characteristic analysis to predict IVA revealed a sensitivity of 89% and a specificity of 83% (area under curve, mean +/- SEM: 0.9 +/- 0.07; P < .001). In patients with left axis deviation (n = 26), IVA showed significantly decreased QRS integrals 10 cm caudal from V1: at a cutoff value of -89 milliseconds mV, receiver operating characteristic analysis to predict IVA revealed a sensitivity of 83% and a specificity of 100% (area under curve, mean +/- SEM: 0.9 +/- 0.07; P < .002). CONCLUSIONS:Interventricular asynchrony strongly correlates with QRS integral. Key lead positions, however, are axis dependent and outside standard leads.

journal_name

J Electrocardiol

authors

Samol A,Klotz S,Stypmann J,Bruns HJ,Houben R,Paul M,Vahlhaus C

doi

10.1016/j.jelectrocard.2009.12.006

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

242-50

issue

3

eissn

0022-0736

issn

1532-8430

pii

S0022-0736(09)00625-6

journal_volume

43

pub_type

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