Abstract：
:One of the most important components of mechanoelectric coupling is stretch-activated channels, sarcolemmal channels that open upon mechanical stimuli. Uncovering the mechanisms by which stretch-activated channels contribute to ventricular arrhythmogenesis under a variety of pathologic conditions is hampered by the lack of experimental methodologies that can record the 3-dimensional electromechanical activity simultaneously at high spatiotemporal resolution. Computer modeling provides such an opportunity. The goal of this review is to illustrate the utility of sophisticated, physiologically realistic, whole heart computer simulations in determining the role of mechanoelectric coupling in ventricular arrhythmogenesis. We first present the various ways by which stretch-activated channels have been modeled and demonstrate how these channels affect cardiac electrophysiologic properties. Next, we use an electrophysiologic model of the rabbit ventricles to understand how so-called commotio cordis, the mechanical impact to the precordial region of the heart, can initiate ventricular tachycardia via the recruitment of stretch-activated channels. Using the same model, we also provide mechanistic insight into the termination of arrhythmias by precordial thump under normal and globally ischemic conditions. Lastly, we use a novel anatomically realistic dynamic 3-dimensional coupled electromechanical model of the rabbit ventricles to gain insight into the role of electromechanical dysfunction in arrhythmogenesis during acute regional ischemia.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Trayanova NA,Constantino J,Gurev Vdoi
10.1016/j.jelectrocard.2010.05.014subject
Has Abstractpub_date
2010-11-01 00:00:00pages
479-85issue
6eissn
0022-0736issn
1532-8430pii
S0022-0736(10)00210-4journal_volume
43pub_type
杂志文章,评审abstract：:Hypertrophic cardiomyopathy (HCM) have been reported to display impaired heart rate variability, although little is known regarding its prognostic value. By using fast Fourier transformation of 24-hour Holter recordings in 73 HCM patients at a stable clinical condition, we computed 4 spectral components: very low freq...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/s0022-0736(00)80106-5
更新日期：2000-01-01 00:00:00
abstract：:The left ventricle (LV) plays a central role in the maintenance of health of children and adults due to its role as the major pump of the heart. In cases of LV dysfunction, a significant percentage of affected individuals develop signs and symptoms of congestive heart failure, leading to the need for therapeutic inter...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2019.07.014
更新日期：2019-01-01 00:00:00
abstract：:We have analyzed the Wilson ventricular gradient in terms of body surface potential maps and of the reduction of such surface patterns to equivalent dipoles or vectors. While the ventricular gradient traditionally was treated as first a scalar, then a vector concept, we found that the three entities (QRS area, T area,...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(81)81013-8
更新日期：1981-10-01 00:00:00
abstract：BACKGROUND:Measuring repolarization characteristics is challenging and has been reserved for experienced physicians. In electrocardiographic imaging (ECGI), activation-recovery interval (ARI) is used as a measure of local cardiac repolarization duration. We hypothesized that repolarization characteristics, such as loca...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2020.02.003
更新日期：2020-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2015.02.005
更新日期：2015-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(92)90080-j
更新日期：1992-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(10)80029-9
更新日期：1992-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.05.004
更新日期：2010-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2000.18107
更新日期：2000-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-0736(84)80020-5
更新日期：1984-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(89)90037-x
更新日期：1989-07-01 00:00:00
abstract：:We report a case of 54-year-old man who presented to hospital with severe prolonged retrosternal chest pain of anginal nature. Electrocardiogram taken by his general practitioner showed minimal ST elevation in chest leads V1 and V2; there was also marked right axis deviation of P wave (negative in lead I and aVL) and ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2005.06.036
更新日期：2005-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2007.10.006
更新日期：2008-03-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(96)80082-3
更新日期：1996-07-01 00:00:00
abstract：:The authors investigated 244 consecutive patients with suspected coronary artery disease by coronary angiography and quantitative left ventriculography to compare the Minnesota Q/QS code (MC) with clinical electrocardiographic (ECG) interpretation. Patients who were suspected to have wall motion abnormalities for reas...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(93)90006-y
更新日期：1993-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2005.11.002
更新日期：2006-10-01 00:00:00
abstract：:Left ventricular systolic function, determined mainly by final infarct size, has a major influence on prognosis after acute myocardial infarction (MI). It was found that infarct size and left ventricular ejection fraction can be predicted using the Selvester QRS-score in patients not receiving reperfusion therapy. We ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.200.20345
更新日期：2000-01-01 00:00:00
abstract：:An 85-year-old male was implanted with a single-chamber permanent pacemaker because of atrial fibrillation with slow ventricular response. The patient had a chronic hearing impairment and decided to buy a hearing aid device. The MyLink device (MyLink, Phonak, Stafa, Switzerland) is a multifrequency FM transmitter/rece...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2008.01.008
更新日期：2008-09-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(97)80013-1
更新日期：1997-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)80022-8
更新日期：1982-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2015.08.032
更新日期：2015-11-01 00:00:00
abstract：:Brugada phenocopies are clinical entities characterized by electrocardiographic patterns that are identical to true Brugada syndrome, but are elicited by a number of clinical circumstances. ECG normalizes upon resolution of underlying condition, family history of arrhythmic syncope or ventricular arrhythmias is strict...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2019.04.003
更新日期：2019-01-01 00:00:00
abstract：:A method has been developed for establishing a "University Without Walls" for the purpose of studying the relationship between electrocardiographic estimation and magnetic resonance imaging measurements of myocardial infarct size. The research team includes faculty and students from 4 medical centers, with expertise e...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2001.28810
更新日期：2001-01-01 00:00:00
abstract：:The addition of propranolol to mexiletine may reduce the adverse effects of mexiletine and possibly increase its efficacy. We compared the cellular electrophysiologic effects of this combination with mexiletine and propranolol alone, over concentration ranges of 3.2 to 100 microM mexiletine and 0.80 to 25.0 microM pro...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(87)80080-8
更新日期：1987-11-01 00:00:00
abstract：OBJECTIVE:Assess effect of right ventricular pacing (RVP) on left ventricular (LV) activation in heart failure patients with left bundle branch block (LBBB). BACKGROUND:LV activation during RVP is regarded as similar to LBBB; hence novel CRT algorithms may avoid RVP by adopting "fusion" pacing with intrinsic RBB-media...
journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jelectrocard.2014.09.002
更新日期：2015-01-01 00:00:00
abstract：:The origin of ST depression in ischemia remains poorly understood. The accepted source is of intracellular current flowing between the ischemic and non ischaemic muscle both in systole and diastole such that the AC recorded electrocardiogram shows ST elevation over the ischemic area. The difficulty comes with partial ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2003.09.002
更新日期：2003-01-01 00:00:00
abstract：:Here we report the identification of two novel mutations in a previously asymptomatic young man who suffered an out-of-hospital sudden cardiac arrest. During following evaluation, diagnosis of early stage dilated cardiomyopathy was established, while electrocardiogram monitoring showed frequent complex ventricular arr...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.12.015
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Reducing time to reperfusion treatment for patients with ST-segment elevation myocardial infarction (STEMI) improves patient outcomes. Few medical systems consistently meet current benchmarks regarding timely access to treatment. Studies have widely demonstrated that prehospital 12-lead electrocardiography c...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.03.011
更新日期：2009-09-01 00:00:00
