Abstract：
:The left ventricle (LV) plays a central role in the maintenance of health of children and adults due to its role as the major pump of the heart. In cases of LV dysfunction, a significant percentage of affected individuals develop signs and symptoms of congestive heart failure, leading to the need for therapeutic intervention. Therapy for these patients include anticongestive medications and, in some, placement of devices such as aortic balloon pump or left ventricular assist device, or cardiac transplantation. In the majority of patients the origin is unknown, leading to the term idiopathic dilated cardiomyopathy. During the past decade, the basis of LV dysfunction has begun to unravel. In approximately 30% to 40% of cases, the disorder is inherited; autosomal dominant inheritance is most common (although X-linked, autosomal recessive and mitochondrial inheritance occurs). In the remaining patients, the disorder is presumed to be acquired, with inflammatory heart disease playing an important role. In the case of familial dilated cardiomyopathy, the genetic basis is beginning to unfold. To date, 2 genes for X-linked familial dilated cardiomyopathy (dystrophin, G4.5) have been identified and 4 genes for the autosomal dominant form (actin, desmin, lamin A/C, delta-sarcoglycan) have been described. In 1 form of inflammatory heart disease, coxsackievirus myocarditis, inflammatory mediators, and dystrophin cleavage play a role in the development of LV dysfunction. This review describes the molecular genetics of LV dysfunction and provide evidence for a "final common pathway" responsible for the phenotype.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Towbin JA,Bowles NEdoi
10.1054/jelc.2001.28859keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
151-65eissn
0022-0736issn
1532-8430pii
ajelc034b0151journal_volume
34 Supplpub_type
杂志文章,评审abstract：:To show that cycle-length (CL) prolongation occurring at the onset of reentrant tachycardias may be associated with an increase in conduction time (CT), and to investigate the involvement of Na+ and Ca2+ channel activity, reentrant activity was induced by programmed stimulation in thin ventricular muscle slices with a...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2000.18107
更新日期：2000-10-01 00:00:00
abstract：:A 52-year-old woman exhibited Mobitz type II atrioventricular block with right bundle branch block and 1:1 atrioventricular conduction at or slower than 80 beats/min. Electrophysiologic study revealed transient HV interval block followed by recovery from the block at shorter coupling intervals without prolongation of ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(98)90009-7
更新日期：1998-01-01 00:00:00
abstract：:Serial electrocardiograms (ECGs) of 49 patients receiving adriamycin were analyzed for the development of persistent changes. The ECG changes were compared with those of a control group of 20 patients receiving other chemotherapeutic drugs, which were comparable to the additional chemotherapy received by the adriamyci...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(78)80122-8
更新日期：1978-07-01 00:00:00
abstract：:We report a case of 54-year-old man who presented to hospital with severe prolonged retrosternal chest pain of anginal nature. Electrocardiogram taken by his general practitioner showed minimal ST elevation in chest leads V1 and V2; there was also marked right axis deviation of P wave (negative in lead I and aVL) and ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2005.06.036
更新日期：2005-10-01 00:00:00
abstract：INTRODUCTION:Left ventricular hypertrophy (LVH), defined as an increased left ventricular mass (LVM), can manifest as increased wall thickness, ventricular dilatation, or both. Existing LVH criteria from the electrocardiogram (ECG) have poor sensitivity. However, it is unknown whether changes in wall thickness and mass...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2019.09.024
更新日期：2020-01-01 00:00:00
abstract：:Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac a...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2007.05.036
更新日期：2007-11-01 00:00:00
abstract：:A comparison was performed between the points measured using the Selvester QRS scoring system in 60 electrocardiograms (ECGs) displayed in both a standard format as well as a 4-fold magnified (quad-plot) format. Fifty criteria (a maximum possibility of 31 points) were evaluated in each ECG. The data indicate that in 5...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2006.07.008
更新日期：2007-07-01 00:00:00
abstract：:The electrocardiographic transient display of left ventricular hypertrophy (LVH), during rapid heart rates, in the setting of sinus/supraventricular tachycardias and atrial fibrillation, is illustrated via 3 case reports. This common occurrence is expressed by an increase in the S-waves in leads V2-V5, during tachycar...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2021.01.001
更新日期：2021-01-09 00:00:00
abstract：:We have developed a computer program which simulates a paced cardiac rhythm strip, graphically generating the electrocardiogram (ECG) on a color monitor. Any pacemaker, programmed as desired, dynamically interacts with a preselected intrinsic rhythm. Utilizing symbols prevalent in the pacing industry, this graphics-or...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:In a patient with the sick sinus syndrome and near syncope a prolonged sinus pause was documented and reproduced thereafter during sustained deep inspiration. Administration of intravenous atropine abolished this phenomenon, most probably indicating a hyperresponsiveness of the sinus node and AV junction to a vagotoni...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(86)80012-7
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Cardiovascular complications are considered a significant problem in patients with chronic kidney disease (CKD). Body surface potential mapping (BSPM) is a noninvasive method that is useful in detecting early changes involving the heart. The aim of the study was to evaluate possible abnormalities within the ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2008.09.007
更新日期：2009-03-01 00:00:00
abstract：:Brugada syndrome is characterized by J wave and ST-segment elevation of right precordial leads and causes idiopathic ventricular fibrillation. We experienced a patient of Brugada syndrome with prominent J wave and ST-segment elevation not only in V(1) to V(3) but also in many leads. He suffered spontaneous ventricular...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2004.07.002
更新日期：2004-10-01 00:00:00
abstract：:Recent studies have reported the relation between Torsade de Pointes (TdP) and midmyocardial (M) cell function associated with long QT syndrome. To investigate this relation, we conducted a simulation study with a three-dimensional (3D) heart model incorporating M cells in the anterolateral areas of the model. Paramet...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(98)90308-9
更新日期：1998-01-01 00:00:00
abstract：:A patient with acute extensive anterior and old inferior wall myocardial infarction developed left anterior hemiblock, resulting in loss of the electrocardiographic evidence of infarction. While the vectorcardiogram has generally been found useful in diagnosing coexistent hemiblock and inferior myocardial infarction, ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(80)80017-3
更新日期：1980-01-01 00:00:00
abstract：AIM:The aim of this study was to investigate whether interventricular asynchrony (IVA) can be measured by electrocardiography. METHODS:Sixty-two patients (New York Heart Association heart failure functional class III: age, mean +/- SD: 64 +/- 9 years; ejection fraction, mean +/- SD: 24% +/- 8%; dilative cardiomyopathy...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.12.006
更新日期：2010-05-01 00:00:00
abstract：:We present an example of sudden modification in QRS morphology during ventricular pacing inside a scar-related isthmus. This is explained by a "concealed" sudden block in both the orthodromic and antidromic wavefront directions, allowing then the activation to proceed through a now overt antidromic conduction. ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2016.07.035
更新日期：2016-01-01 00:00:00
abstract：:The dominant T wave (DTW) reflects the derivative of the repolarization phase of the transmembrane potential of myocytes. T-wave alternans (TWA) is defined as an alteration of this repolarization that repeats every other beat. We investigate if the DTW can offer new insight on TWA. We first proved that the DTW estimat...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.11.017
更新日期：2011-03-01 00:00:00
abstract：:The long term prognosis was studied in 50 patients treated for the sick sinus syndrome with pacemaker insertion. The mean age of the patients was 71 years. There were 31 females and 19 males in the series. Nine patients (18%) died during the average follow-up period of 19 months. Dizzy and syncopal episodes were aboli...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(78)80023-5
更新日期：1978-01-01 00:00:00
abstract：:Left ventricular (LV) dysfunction after myocardial infarction is associated with higher risk of serious ventricular arrhythmias and sudden death. We suspected that heterogeneity in ventricular repolarization contributes to these arrhythmias. To quantify this heterogeneity, we measured the recovery time (the interval b...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2003.50005
更新日期：2003-01-01 00:00:00
abstract：:Central venous catheters extending into intracardiac chambers can provoke premature atrial and ventricular complexes, which have been reported to initiate supraventricular tachyarrhythmias. These catheters are traditionally placed via the femoral, subclavian, or internal jugular veins. A new alternative to the convent...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(96)80116-6
更新日期：1996-01-01 00:00:00
abstract：:Ventricular fibrillation (VF) is the most common arrhythmia leading to sudden cardiac death, but in rare cases VF can manifest as a syncope, provided that it will self-terminate. We present a case of a 45-year old female with a history of unexplained syncopal episodes despite exhaustive diagnostics. Implantable loop r...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.04.006
更新日期：2018-01-01 00:00:00
abstract：:The sensitivity of an extensive electrocardiographic examination to local cardiac regions was evaluated by comparison with findings in vectorcardiographic leads. Evaluation consisted of comparing QRS areas during different ventricular activation patterns. The ratio of areas from the vector-cardiogram (VCG) and extensi...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(76)80009-x
更新日期：1976-01-01 00:00:00
abstract：:Early recognition of ST-segment elevation myocardial infarction equivalent electrocardiogram patterns is of paramount importance. Successful identification of these ischemic patterns helps ensure proper triage of patients needing urgent restoration of coronary perfusion. The so-called de Winter sign has become increas...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2020.06.002
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:This study aims to develop a noninvasive atrial remodeling index (RI) to separate patients presenting paroxysmal atrial fibrillation (ParAF) from those with sustained persistent atrial fibrillation (PerAF), that is, AF episodes interrupted 7 days or more after the onset. METHODS:Signal-averaged P-wave duration...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2011.08.005
更新日期：2012-03-01 00:00:00
abstract：:A low-cost micro-processor combined with a standard 3-channel electrocardiographic recorder was adapted to polar coordinate conversion of Frank orthogonal lead signals and display of the resultant polarcardiogram. The processor also functions as a computer of average transients for the ECG complexes and provides autom...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)80047-2
更新日期：1982-01-01 00:00:00
abstract：:Electrocardiograms were taken from a 67-year-old man with 2:1 atrioventricular block in whom alternating reversed Wenckebach periodicity was found. Long PR intervals of alternately conducted P waves progressively shortened until an alternate P wave was blocked. After an alternate P wave was blocked, the next alternate...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2003.50010
更新日期：2003-01-01 00:00:00
abstract：:Repetitive nonreentrant ventriculoatrial synchrony during dual-chamber pacing is characterized by long intervals alternating with short intervals. This arrangement activated automatic mode switching in a St Jude dual-chamber pacemaker in which the algorithm requires an atrial sensed event for automatic mode switching ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.04.003
更新日期：2012-07-01 00:00:00
abstract：:The Brugada syndrome is characterized by ST-segment elevation in the right precordial leads (V1 through V3) and an episode of ventricular fibrillation in the absence of structural heart disease. SCN5A, the gene encoding the alpha subunit of the sodium channel, is the only gene thus far linked to the Brugada syndrome b...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2005.06.005
更新日期：2005-10-01 00:00:00
abstract：AIM:LBBB in heart failure patients has prognostic significance. Subtypes of LBBB (concordant and discordant) have not been considered when considering management. The aim of this study is to explore the clinical difference between the two subtypes. METHODS:216 patients with LBBB were included and categorized into conc...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2015.08.031
更新日期：2016-01-01 00:00:00
abstract：:Sources of error in averaging for late ventricular potentials include variations in the magnitude and timing of late potentials as well as variability in the temporal alignment of successive cardiac cycles during averaging. Since these errors can both attenuate high frequency signals and add artifactual components to ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
