Abstract：
:Five male patients with chronic stable ventricular arrhythmias underwent a placebo controlled ascending dose study with oral cibenzoline, a new type 1 antiarrhythmic drug. Ambulatory ECG (Holter) recordings and electrophysiologic studies were done while on placebo and on the maximum dose of cibenzoline. Drug toxicity, manifested by vomiting and QRS widening, accompanied by very high serum cibenzoline concentrations, was seen in two patients. A major reduction (greater than 85% in ventricular premature beats occurred in three patients including two in whom only relatively low serum concentrations had been achieved. Cibenzoline caused significant increases in AH (97 +/- 26 vs. 110 +/- 23 msec, p less than 0.01) and HV (59 +/- 7 vs. 78 +/- 7 msec, p less than 0.02), a major but statistically not significant increase in QRS (99 +/- 12 vs. 128 +/- 27 msec, NS) but QT (38 +/- 2 vs. 38 +/- msec) and QTc (42 +/- 1 vs. 44 +/- 3 msec) were essentially unchanged, even in toxic patients. Cibenzoline had no consistant effect on sinus cycle length, sinus node recovery time, or the relative, functional or effective refractory periods of the atrium and AV node. We conclude that cibenzoline has potent type 1 effects in prolonging HV but may be unique in not affecting QT or QTc, even at toxic levels. Its effects upon AH were unexpected and warrant further study.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Kushner M,Magiros E,Peters R,Carliner N,Plotnick G,Fisher Mdoi
10.1016/s0022-0736(84)80020-5subject
Has Abstractpub_date
1984-01-01 00:00:00pages
15-23issue
1eissn
0022-0736issn
1532-8430journal_volume
17pub_type
临床试验,杂志文章abstract：:This study described the linear relationship of the myocardial infarct size, measured postmortem, to the integral of the sequential vector spatial magnitudes analyzed at 400 samples per second during the initial period of abnormal depolarization (IAD) in 25 patients with myocardial infarction (MI) and ten controls. Th...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)81002-9
更新日期：1982-10-01 00:00:00
abstract：:The dominant T wave (DTW) reflects the derivative of the repolarization phase of the transmembrane potential of myocytes. T-wave alternans (TWA) is defined as an alteration of this repolarization that repeats every other beat. We investigate if the DTW can offer new insight on TWA. We first proved that the DTW estimat...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.11.017
更新日期：2011-03-01 00:00:00
abstract：:One of the most important components of mechanoelectric coupling is stretch-activated channels, sarcolemmal channels that open upon mechanical stimuli. Uncovering the mechanisms by which stretch-activated channels contribute to ventricular arrhythmogenesis under a variety of pathologic conditions is hampered by the la...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2010.05.014
更新日期：2010-11-01 00:00:00
abstract：:Direct Wenckebach periods in the left bundle branch with periods of 4:3 and 5:4 conduction alternating with 2:1 left bundle branch block (LBBB) were observed in a patient who was admitted because of congestive heart failure. There was no previous documented LBBB and serial electrocardiographic (ECG) mainfestations aft...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(80)80034-3
更新日期：1980-01-01 00:00:00
abstract：:We present a case of an anterior ST-segment elevation acute coronary syndrome secondary to occlusion of a non-dominant right coronary artery. Usually, an anterior ST-segment elevation corresponds to a left anterior descending artery occlusion; however, in rare cases it can be secondary to a non-dominant right coronary...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.07.017
更新日期：2018-01-01 00:00:00
abstract：:Considerable efforts have been invested recently to improve electrocardiographic (ECG) classification accuracy for left ventricular hypertrophy (LVH). This study examines how LVH classification accuracy is influenced by (1) the selection of an echocardiographic standard for LVH, (2) LVH severity level in the test grou...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(96)80073-2
更新日期：1996-01-01 00:00:00
abstract：UNLABELLED:Cardiac function management devices, including implantable pacemakers and implantable defibrillators, include at least 1 cardiac lead having an electrode for making contact with a portion of the heart. It has been previously shown that the braided multifilament wire electrodes have a high failure rate both f...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.07.019
更新日期：2009-11-01 00:00:00
abstract：:In 37 consecutive patients with acute myocardial infarction undergoing Streptokinase infusion and acute coronary angiography, the electrocardiographic findings were compared with the findings during angiography. All 15 patients with an occluded right coronary artery demonstrated an electrocardiographic pattern of an a...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(84)80062-x
更新日期：1984-07-01 00:00:00
abstract：:The electrocardiographic transient display of left ventricular hypertrophy (LVH), during rapid heart rates, in the setting of sinus/supraventricular tachycardias and atrial fibrillation, is illustrated via 3 case reports. This common occurrence is expressed by an increase in the S-waves in leads V2-V5, during tachycar...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2021.01.001
更新日期：2021-01-09 00:00:00
abstract：:Here we report the identification of two novel mutations in a previously asymptomatic young man who suffered an out-of-hospital sudden cardiac arrest. During following evaluation, diagnosis of early stage dilated cardiomyopathy was established, while electrocardiogram monitoring showed frequent complex ventricular arr...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.12.015
更新日期：2019-01-01 00:00:00
abstract：:The American College of Cardiology recommends that patients with high risk acute myocardial infarction (AMI) be triaged to hospitals with percutaneous transluminal coronary angioplasty capability. However, there are no prehospital triage criteria to select candidates for bypassing community hospitals and being taken d...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2000.20299
更新日期：2000-01-01 00:00:00
abstract：:Recent studies have shown that ventricular myocardium is composed of at least 3 electrophysiologically distinct cell types: epicardial, endocardial, and M cells. Action potentials recorded from epicardial and M cells, unlike those recorded from endocardium, display a spike-and-dome morphology, the result of a prominen...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/s0022-0736(99)90074-2
更新日期：1999-01-01 00:00:00
abstract：:15-Year-old man's cardiac event monitor showed an episode of wide complex tachycardia which transitioned into narrow complex tachycardia. The tachycardia cycle length was shorter during wide complex tachycardia compared with narrow complex tachycardia. He underwent electrophysiology study in which an orthodromic atrio...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2020.02.002
更新日期：2020-01-01 00:00:00
abstract：:The authors investigated 244 consecutive patients with suspected coronary artery disease by coronary angiography and quantitative left ventriculography to compare the Minnesota Q/QS code (MC) with clinical electrocardiographic (ECG) interpretation. Patients who were suspected to have wall motion abnormalities for reas...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(93)90006-y
更新日期：1993-04-01 00:00:00
abstract：:The origin of ST depression in ischemia remains poorly understood. The accepted source is of intracellular current flowing between the ischemic and non ischaemic muscle both in systole and diastole such that the AC recorded electrocardiogram shows ST elevation over the ischemic area. The difficulty comes with partial ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2003.09.002
更新日期：2003-01-01 00:00:00
abstract：:Many electrocardiographic criteria have been proposed for the differentiation of ventricular extrasystole and supraventricular conduction with aberrancy in atrial fibrillation but the validity of these have not been confirmed by intracardiac studies. We recorded His bundle electrograms in nineteen patients (eleven men...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(85)80033-9
更新日期：1985-01-01 00:00:00
abstract：PURPOSE:This study aims to develop a noninvasive atrial remodeling index (RI) to separate patients presenting paroxysmal atrial fibrillation (ParAF) from those with sustained persistent atrial fibrillation (PerAF), that is, AF episodes interrupted 7 days or more after the onset. METHODS:Signal-averaged P-wave duration...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2011.08.005
更新日期：2012-03-01 00:00:00
abstract：:An interpolated premature ventricular contraction (PVC) may produce either complete block of the next sinus impulse or depression of A-V nodal conduction with a prolonged A-H interval. When a PVC results in partial depression of a A-V nodal conduction, the effect on subsequent premature atrial stimuli is unknown. The ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(77)80025-3
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:Interatrial block (IAB; P waves >/= 110 milliseconds), the conduction delay between the right (RA) and left atrium (LA), is depicted on the electrocardiogram (ECG) as prolonged, often bifid ("notched"), P waves with distinguishable RA and LA components. Although electrophysiologic (EP) studies give some insi...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2005.11.002
更新日期：2006-10-01 00:00:00
abstract：:The electrophysiologic actions of epinephrine (10(-9) M, 10(-8) M, and 10(-7) M) were evaluated in canine Purkinje fibers pretreated with the class III antiarrhythmic drugs clofilium (10(-7) M) or d,l-sotalol (10(-6) M). Clofilium and d,l-sotalol prolonged action potential duration at 50% and 90% of repolarization wit...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(97)80007-6
更新日期：1997-07-01 00:00:00
abstract：:A 53-year-old woman with sinus node dysfunction underwent dual-chamber pacemaker implantation through a persistent left superior vena cava draining into the coronary sinus, which was detected at the time of implantation. We managed to fix the ventricular lead in the right ventricular (RV) apex by forming a clockwise l...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2007.05.016
更新日期：2007-11-01 00:00:00
abstract：:We present a case of a woman with an asymptomatic intermittent 2:1 atrioventricular block. The baseline ECG showed a wide QRS with right bundle branch block pattern. Measurement of the HV interval during electrophysiological study was normal. During electrophysiological stimulation, a unique pattern of paradoxical con...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2017.03.003
更新日期：2017-01-01 00:00:00
abstract：:Extra AV nodal Wenckebach periodicity was diagnosed in seven patients. The most frequent form of this conduction abnormality was an exit block. The underlying block was localized in the sinoatrial junction and in the atria in two patients; the AV junction and the ventricle were the site of the Wenckebach periodicity i...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(81)80003-9
更新日期：1981-07-01 00:00:00
abstract：:The numerous criteria proposed for the electrocardiographic (ECG) diagnosis of biventricular hypertrophy (BVH) suffer from inadequate correlative data. We used two-dimensional (2D) echocardiography to identify BVH and analyzed the ECG patterns in these patients. The study group had 69 such patients with BVH and the co...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:A successive RR interval plot was developed to analyze arrhythmia. The plot consisted of a set of points with the x-value of (N)th RR interval and the y-value of (N + 1)th RR interval. This method was applied in the arrhythmia analysis of Holter electrocardiograms obtained from 35 patients. In the analysis of ventricu...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(90)90163-v
更新日期：1990-07-01 00:00:00
abstract：:The objective of this study is to assess the performance of patient-specific segment-specific (PSSS) synthesis in QRST complexes using CAVIAR, a new method of the serial comparison for electrocardiograms and vectorcardiograms. A collection of 250 multi-lead recordings from the Common Standards for Quantitative Electro...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(92)90080-j
更新日期：1992-01-01 00:00:00
abstract：:A 65-year old male originally presented with repetitive ventricular bigeminal sequences demonstrating progressive prolongation of successive coupling intervals suggesting Wenckeback-type exit block. An even number distribution of conducted beats always intervened between bigeminal sequences. Subsequent analysis proved...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(78)80146-0
更新日期：1978-10-01 00:00:00
abstract：:A graph consisting of small squares of equal size preprinted on a transparent plastic chart can be used for a quick and accurate calculation of the VCG loop area in each quadrant of the three conventional planes. ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(79)80013-8
更新日期：1979-10-01 00:00:00
abstract：:Syncope is a risk factor for sudden cardiac death (SCD) in many conditions associated with structural heart disease as well as inherited heart disease. The ECG in patients with syncope should be examined carefully for signs of structural heart disease, such as myocardial infarction or cardiomyopathy; signs of conducti...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2013.07.008
更新日期：2013-11-01 00:00:00
abstract：:The ability of ECG-VCG to predict the severity of postinfarction LV asynergy was evaluated in 152 patients with previous myocardial infarction who underwent left cineventriculography in the right anterior oblique view. Various ECG and VCG signs were examined in order to predict the existence of severe asynergy in gene...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(84)81092-4
更新日期：1984-04-01 00:00:00
