Abstract：
:Here we report the identification of two novel mutations in a previously asymptomatic young man who suffered an out-of-hospital sudden cardiac arrest. During following evaluation, diagnosis of early stage dilated cardiomyopathy was established, while electrocardiogram monitoring showed frequent complex ventricular arrhythmias, incomplete right bundle branch block and prolonged QT duration. No reversible causes explaining the clinical presentation were established and an automatic implantable cardioverter defibrillator was therefore implanted. Heterozygous mutations in human protein coding genes NKX2-5 and RBM20 are associated with a wide array of pathological phenotypes some of which are sudden cardiac death, unexplained syncope and either combined or isolated congenital heart diseases such as dilated cardiomyopathy.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Monaco I,Santacroce R,Casavecchia G,Correale M,Bottigliero D,Cordisco G,Leccese A,Di Biase M,Margaglione M,Brunetti NDdoi
10.1016/j.jelectrocard.2018.12.015subject
Has Abstractpub_date
2019-01-01 00:00:00pages
40-43eissn
0022-0736issn
1532-8430pii
S0022-0736(18)30736-2journal_volume
53pub_type
杂志文章abstract：:The electrocardiographic criteria for isolated left anterior fascicular block are reviewed and illustrated. Left anterior fascicular block decreases the voltage in the chest leads and increases the voltage in the limb leads. The usual voltage criteria of left ventricular hypertrophy must be modified appropriately. Cha...
journal_title：Journal of electrocardiology
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abstract：BACKGROUND AND PURPOSE:Descriptions of the significance of ST segment or QRS abnormalities in myocarditis are limited because documentation of the diagnosis has previously required myocardial biopsy. Late gadolinium enhancement (LGE) and T2 weighted imaging in the midventricular wall on cardiac magnetic resonance imagi...
journal_title：Journal of electrocardiology
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：
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abstract：BACKGROUND:Electrocardiogram (ECG) screening in athletes enhances the detection of conditions associated with sudden cardiac death (SCD), but concerns remain for false positive results when conducted outside of specialized centers. This study compared ECG interpretation in college athletes between local physicians and ...
journal_title：Journal of electrocardiology
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更新日期：2020-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(90)90119-m
更新日期：1990-10-01 00:00:00
abstract：:The Brugada syndrome is characterized by ST-segment elevation in the right precordial leads (V1 through V3) and an episode of ventricular fibrillation in the absence of structural heart disease. SCN5A, the gene encoding the alpha subunit of the sodium channel, is the only gene thus far linked to the Brugada syndrome b...
journal_title：Journal of electrocardiology
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.02.004
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(10)80019-6
更新日期：1992-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/s0022-0736(96)80100-2
更新日期：1996-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2003.09.002
更新日期：2003-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.05.009
更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jelectrocard.2015.04.013
更新日期：2015-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.03.005
更新日期：2012-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(86)80017-6
更新日期：1986-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.04.001
更新日期：2012-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)80014-9
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2008.07.022
更新日期：2008-11-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.02.005
更新日期：2012-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2007.10.006
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2003.09.022
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journal_title：Journal of electrocardiology
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doi：10.1016/s0022-0736(77)80037-x
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journal_title：Journal of electrocardiology
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2003.50010
更新日期：2003-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2017.08.032
更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2000.8398
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(87)80098-5
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abstract：BACKGROUND:The use of vectorcardiography (VCG) has regained interest, however, original Frank-VCG equipment is rare. This study compares the measured VCGs with those synthesized from the 12-lead electrocardiogram (ECG) in patients with heart failure and conduction abnormalities, who are candidate for cardiac resynchron...
journal_title：Journal of electrocardiology
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pub_type： 杂志文章
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2005.09.001
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abstract：:The authors have proposed a new four-step screening algorithm to detect asymptomatic coronary artery disease (CAD) in flight school candidates, cadets, and rated flyers of the Unites States Air Force (USAF). In step 1, the USAF Armstrong Laboratory (USAF/AL) risk profile and improved 16-lead high-resolution electrocar...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
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