当前位置： SCI文献检索 > JOURNAL OF ELECTROCARDIOLOGY期刊下所有文献 > Nicorandil attenuates both temporal and spatial repolarization alternans.

Nicorandil attenuates both temporal and spatial repolarization alternans.

Abstract：

:T-wave alternans (TWA) on the electrocardiogram have been frequently associated with long QT syndrome (LQTS) and abrupt rate change. The present study investigated the effect of the potassium channel opener nicorandil on the repolarization alternans at the endocardium and the epicardium in the left ventricle. Electrocardiogram and transmural monophasic action potentials from the endocardium and the epicardium were simultaneously recorded in Langendorff-perfused guinea pig hearts. The hearts were paced at a basic cycle length (BCL) of 240 ms and the cycle length (CL) was abruptly shortened to 170 ms to induce repolarization alternans. Disopyramide and nicorandil were used to increase or attenuate repolarization alternans, respectively. Repolarization alternans were numerically expressed as the sum of the absolute difference between consecutive monophasic action potential durations at 90% repolarization (MAPD90) in the first 10 beats. In the control hearts, the MAPD90 alternans were 78.6 +/- 14.9 ms at the endocardium, and 49.8 +/- 58 ms at the epicardium (P = .03 endocardium vs epicardium). Disopyramide (2 microg/mL) increased the MAPD90 alternans to 186.6 +/- 30.6 ms at the endocardium and 116.4 +/- 16.5 ms at the epicardium, and enhanced the difference of repolarization alternans between the endocardium and the epicardium (transmural dispersion) from 28.8 +/- 11.3 ms to 70.2 +/- 18.7 ms (P = .02 vs controls). Nicorandil (400 ng/mL) suppressed the MAPD90 alternans to 79.6 +/- 16.3 ms at the endocardium and 56.0 +/- 11.8 ms at the epicardium, and attenuated the transmural dispersion to 23.6 +/- 6.0 ms (P = .02 vs disopyramide-administrated hearts). Our results suggest that nicorandil attenuates both temporal (beat-to-beat) and spatial (between the endocardium and the epicardium) repolarization alternans induced by the combination of cycle length changes and disopyramide administration.

journal_name

J Electrocardiol

journal_title

Journal of electrocardiology

authors

Fujimoto Y,Kusano KF,Morita H,Hong K,Yamanari H,Ohe T

doi

10.1054/jelc.2000.8398

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

269-77

issue

3

eissn

0022-0736

issn

1532-8430

pii

S002207360019003X

journal_volume

33

pub_type

杂志文章

相关文献

JOURNAL OF ELECTROCARDIOLOGY文献大全
  • Comparison of the Selvester QRS scoring system applied on standard versus high-resolution electrocardiographic recordings.

    abstract：:A comparison was performed between the points measured using the Selvester QRS scoring system in 60 electrocardiograms (ECGs) displayed in both a standard format as well as a 4-fold magnified (quad-plot) format. Fifty criteria (a maximum possibility of 31 points) were evaluated in each ECG. The data indicate that in 5...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2006.07.008

    authors： Wagner GS,Greenfield JC Jr,Rembert JC,Warren JW,Albano A,Palmeri MA,Horácek BM

    更新日期：2007-07-01 00:00:00

  • Rate dependent variation in concealed bigeminy.

    abstract：:A 63 year old man with angina pectoris was found to have frequent extrasystoles separated by odd as well as even numbers of conducted sinus beats. Analysis of 935 conducted sinus beats showed that premature ventricular beats without interpolation were separated by odd numbers of conducted sinus beats in 117 sequences ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(82)80033-2

    authors： Bissett JK,Watson JW,Wanta-Matthews M,Ozemek H

    更新日期：1982-01-01 00:00:00

  • Risk of early mortality after placement of a temporary-permanent pacemaker.

    abstract：BACKGROUND:Temporary-permanent pacemakers [TPPM] are externally placed permanent generators attached to active fixation transvenous leads. TPPM can be used as an alternative to standard temporary pacing leads when placement of a permanent pacemaker is contraindicated. We sought to determine the incidence and risk facto...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2016.05.004

    authors： Dawood FZ,Boerkircher A,Rubery B,Hire D,Soliman EZ

    更新日期：2016-07-01 00:00:00

  • False ST elevation in a modified 12-lead surface electrocardiogram.

    abstract：:Precise recording of the standard 12-lead electrocardiogram (ECG) is technically time consuming. Placing limb leads on the torso has the major advantages of ease of use, increased speed of application, and decreased artifact. This modified ECG frequently substitutes for the standard 12-lead ECG in intensive care units...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2007.11.004

    authors： Toosi MS,Sochanski MT

    更新日期：2008-05-01 00:00:00

  • Arrhythmia analysis by successive RR plotting.

    abstract：:A successive RR interval plot was developed to analyze arrhythmia. The plot consisted of a set of points with the x-value of (N)th RR interval and the y-value of (N + 1)th RR interval. This method was applied in the arrhythmia analysis of Holter electrocardiograms obtained from 35 patients. In the analysis of ventricu...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/0022-0736(90)90163-v

    authors： Anan T,Sunagawa K,Araki H,Nakamura M

    更新日期：1990-07-01 00:00:00

  • Atypical AV junctional reentrant tachycardia following AV nodal modification.

    abstract：:The authors present a patient who initially underwent anterior approach atrioventricular (AV) nodal modification for treatment of typical AV junctional reentrant tachycardia (AVJRT) and subsequently developed clinical episodes of a previously undocumented type of supraventricular tachycardia. Findings during electroph...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(05)80113-x

    authors： Goldberger J,Ehlert F,Baerman J,Kadish A

    更新日期：1994-01-01 00:00:00

  • The dominant T wave.

    abstract：:This contribution discusses the dominant T wave, a concept providing an overall view on the repolarization currents of the ventricular myocardium. The dominant T wave is a weighted mean of the T waves on the body surface. It can be estimated from the matrix of sampled observed potentials. The timing of its peak reveal...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2004.08.056

    authors： van Oosterom A

    更新日期：2004-01-01 00:00:00

  • Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies.

    abstract：:The objective of this article is to present a set of methods for constructing realistic computational models of cardiac structure from high-resolution structural and diffusion tensor magnetic resonance images and to demonstrate the applicability of the models in simulation studies. The structural image is segmented to...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2008.12.003

    authors： Vadakkumpadan F,Rantner LJ,Tice B,Boyle P,Prassl AJ,Vigmond E,Plank G,Trayanova N

    更新日期：2009-03-01 00:00:00

  • Pre-hospital evaluation of electrocardiographic grade 3 ischemia predicts infarct progression and final infarct size in ST elevation myocardial infarction patients treated with primary percutaneous coronary intervention.

    abstract：BACKGROUND:In STEMI, grade-3 ischemia (G3) on admission ECG predicts larger infarct size (IS) than grade-2 (G2). We evaluated whether pre-hospital G3 and its temporal behavior are associated with IS and salvage after pPCI. METHODS:In 401 STEMI patients, pre-hospital and pre-PCI ECGs were classified as G3 or G2. IS was...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jelectrocard.2014.04.012

    authors： Ringborn M,Birnbaum Y,Nielsen SS,Kaltoft AK,Bøtker HE,Pahlm O,Wagner GS,Platonov PG,Terkelsen CJ

    更新日期：2014-07-01 00:00:00

  • PR depression with multi‑lead ST elevation and ST depression in aVR: Is it always acute pericarditis?

    abstract：:The classic electrocardiographic (ECG) manifestation of stage I of acute pericarditis is diffuse ST elevation and PR depression with ST depression in lead aVR. One of the most common conditions, that is often confused with acute pericarditis, is the benign diffuse ST elevation, termed "early repolarization with ST ele...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2019.01.085

    authors： Birnbaum Y,Perez Riera AR,Nikus K

    更新日期：2019-01-01 00:00:00

  • A device for producing high frequency electrocardiograms on a conventional direct writing electrocardiograph.

    abstract：:A device has been developed which can be used in conjunction with a direct-writing electrocardiograph to record the high frequency electrocardiogram (ECG) including notches and slurs in the waveform. The device operates on the principle of temporarily storing the QRS complex and then reproducing it at a rate 10 times ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(75)80054-9

    authors： Geselowitz DB,Balogh J,Bishop RR

    更新日期：1975-07-01 00:00:00

  • Intra-QRS spectral changes accompany ST segment changes during episodes of myocardial ischemia.

    abstract：BACKGROUND:Coronary artery disease and myocardial ischemia cause substantial morbidity and mortality. While ischemia is traditionally diagnosed on the 12-lead electrocardiogram (ECG) by shifts in the ST segment, electrical changes are also produced within the QRS complex during depolarization of ischemic ventricular ti...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2014.09.005

    authors： Gramatikov B,Iyer V

    更新日期：2015-01-01 00:00:00

  • P wave analysis with wavelets identifies hypertensive patients at risk of recurrence of atrial fibrillation: A case-control study and 1year follow-up.

    abstract：AIMS:Hypertension is a major risk factor for atrial fibrillation (AF); however, reliable non-invasive tools to assess AF risk in hypertensive patients are lacking. We sought to evaluate the efficacy of P wave wavelet analysis in predicting AF risk recurrence in a hypertensive cohort. METHODS:We studied 37 hypertensive...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2015.07.012

    authors： Dakos G,Konstantinou D,Chatzizisis YS,Chouvarda I,Filos D,Paraskevaidis S,Mantziari L,Maglaveras N,Karvounis H,Vassilikos V

    更新日期：2015-09-01 00:00:00

  • Comparative study of eight sets of ECG criteria for the localization of the accessory pathway in Wolff-Parkinson-White syndrome.

    abstract：:Eight sets of electrocardiographic (ECG) criteria for the localization of accessory conduction pathway (ACP) were evaluated on 182 patients with a single ACP. The Rosenbaum criteria identified 78.6% of the left-sided and 94.0% of the right-sided ACPs. Four of the other seven sets of criteria demonstrated a sensitivity...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/0022-0736(92)90005-k

    authors： Yuan S,Iwa T,Tsubota M,Bando H

    更新日期：1992-07-01 00:00:00

  • Does the abnormal signal-averaged electrocardiogram predict future appropriate therapy in patients with implantable cardioverter-defibrillators?

    abstract：BACKGROUND:Several studies have documented the prognostic significance of the signal-averaged electrocardiogram (SAECG) both after myocardial infarction and nonischemic cardiomyopathy. However, whether the SAECG can identify patients with implantable cardioverter-defibrillator (ICD) who receive appropriate therapy has ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2005.08.009

    authors： Haghjoo M,Arya A,Parsaie M,Dehghani MR,Sadr-Ameli MA

    更新日期：2006-04-01 00:00:00

  • Electrocardiographic classification of acute coronary syndromes: a review by a committee of the International Society for Holter and Non-Invasive Electrocardiology.

    abstract：:The electrocardiogram (ECG) remains the most immediately accessible and widely used diagnostic tool for guiding emergency treatment strategies. The ECG recorded during acute myocardial ischemia is of diagnostic, therapeutic, and prognostic significance. In patients with myocardial ischemia as a result of decreased blo...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jelectrocard.2009.07.009

    authors： Nikus K,Pahlm O,Wagner G,Birnbaum Y,Cinca J,Clemmensen P,Eskola M,Fiol M,Goldwasser D,Gorgels A,Sclarovsky S,Stern S,Wellens H,Zareba W,de Luna AB

    更新日期：2010-03-01 00:00:00

  • Temporary unipolar pacing using a dual cathode.

    abstract：:Using standard biopolar, temporary pacing catheters, thresholds were measured in four configurations: (1) bipolar (distal electrode negative, proximal electrode positive); (2) distal unipolar (distal electrode negative, right arm electrode positive); (3) proximal unipolar (proximal electrode negative, right arm electr...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(76)80077-5

    authors： Preston TA

    更新日期：1976-04-01 00:00:00

  • Electrocardiographic change after recanalization in a patient with recent extensive anterior wall myocardial infarction.

    abstract：:In a 66-year-old male with subacute extensive anterior wall myocardial infarction, we report a change in ST vector orientation from a basal anterior to a mid anterior after coronary artery recanalization of the proximal left anterior descending coronary artery with rotational atherectomy. The ST vector shift on the fr...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2009.05.001

    authors： Akutsu Y,Nishimura H,Hamazaki Y,Kaneko K,Kodama Y,Li HL,Suyama J,Shinozuka A,Gokan T,Kobayashi Y

    更新日期：2009-09-01 00:00:00

  • Differences in amiodarone efficacy in relation to ejection fraction and basal rhythm in patients with implantable cardioverter defibrillators.

    abstract：BACKGROUND:Atrial fibrillation (AF) and ventricular arrhythmias (VAs) are associated with increased morbidity and mortality. However, data are lacking concerning the association of AF and VAs. This study aimed to clarify the association between AF and VAs and to investigate the effect of amiodarone on the incidence of ...

    journal_title：Journal of electrocardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jelectrocard.2018.10.083

    authors： Watanabe T,Inoue K,Kashiwase K,Mine T,Hirooka K,Shutta R,Mizuno H,Okuyama Y,Sakata Y,Nanto S,SATISFACTION Investigators.

    更新日期：2018-01-01 00:00:00

  • The effect of metilpheniydate, risperidone and combination therapy on ECG in children with attention-deficit hyperactivity disorder.

    abstract：INTRODUCTION:This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy. METHODS:A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2017.02.012

    authors： Karpuz D,Hallioglu O,Toros F,Tasdelen B

    更新日期：2017-01-01 00:00:00

  • Electrocardiographic recognition of right ventricular hypertrophy.

    abstract：:The electrocardiogram (ECG) is a relatively insensitive tool for the detection of right ventricular hypertrophy (RVH), but some criteria have high specificity. The recommended ECG screening criteria for RVH are not sufficiently sensitive or specific for screening for mild RVH in adults without clinical cardiovascular ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jelectrocard.2017.09.004

    authors： Nikus K,Pérez-Riera AR,Konttila K,Barbosa-Barros R

    更新日期：2018-01-01 00:00:00

  • Body surface potential mapping investigating the ventricular activation patterns in the cardiac resynchronization of patients with left bundle-branch block and heart failure.

    abstract：:Body surface potential mapping assessed mean cardiac electrical activation times displayed by isochronal maps in the right ventricle (RV; right ventricle mean activation time [mRV]), anterior septal area (anterior septal area mean activation time [mAS]), and left ventricle (left ventricle mean activation time [mLV]) o...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2005.07.004

    authors： Pastore CA,Tobias N,Samesima N,Filho MM,Pedrosa A,Nishioka S,Douglas RA,Moreira LF,Ramires JF

    更新日期：2006-01-01 00:00:00

  • Syncope in a patient with acute pulmonary embolism and Brugada Type-2 ECG pattern: Brugada phenocopy or Brugada syndrome?

    abstract：:Brugada phenocopies are clinical entities characterized by electrocardiographic patterns that are identical to true Brugada syndrome, but are elicited by a number of clinical circumstances. ECG normalizes upon resolution of underlying condition, family history of arrhythmic syncope or ventricular arrhythmias is strict...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/j.jelectrocard.2019.04.003

    authors： Lippolis A,Buzzi MP,Romano IJ,Facchini C,Gentile F

    更新日期：2019-01-01 00:00:00

  • The genesis of indeterminate axis: a quantitative vectorcardiographic analysis.

    abstract：:The vectorcardiographic basis of indeterminate QRS axis has not been elucidated. Accordingly, Frank lead VCGs were obtained on ten consecutive subjects with biphasic QRS complexes in the six extremity leads. The frontal plane vector in each case showed a very narrow loop inscribed in a symmetrical fashion around the E...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(82)80022-8

    authors： Goldberger AL

    更新日期：1982-01-01 00:00:00

  • An approach to direct detection of sinus nodal activity in man.

    abstract：:We are reporting a series of 13 out of a total of 16 patients in whom sinus nodal activity was recorded with the use of intra-atrial electrodes, during diagnostic His-bundle electrocardiography investigations. The protocol consisted of the simultaneous monitoring of the following intra-atrial points: high right atrium...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(79)80002-3

    authors： Hombach V,Gil-Sanchez D,Zanker R,Behrenbeck DW,Tauchert M,Hilger HH

    更新日期：1979-10-01 00:00:00

  • Remodeling of cardiac gap junctions: the relationship to the genesis of ventricular tachycardia.

    abstract：:Cardiac gap junctions are responsible for normal conduction properties of the ventricles. Alteration in gap junction distribution (remodeling) in ischemic heart disease is likely to be an important cause of life threatening ventricular arrhythmias. ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1054/jelc.2001.28834

    authors： Wit AL

    更新日期：2001-01-01 00:00:00

  • Possible role of a ventricular conduction disturbance in the electrogenesis of the ECG-VCG signs of myocardial infarction.

    abstract：:The typical QRS patterns of myocardial infarction (MI-QRS) are commonly attributed to myocardial cellular death. However, observation of a transient appearance of MI-QRS during coronary insufficiency, the disappearance of MI-QRS after coronary by-pass surgery and the appearance of MI-QRS after intracranial hemorrhage ...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(83)80089-2

    authors： Piccolo E,Delise P,Raviele A,D'Este D,Lucangeli F,Pascotto P,Dainese F,Di Pede F

    更新日期：1983-10-01 00:00:00

  • Effective extraction of diagnostic ECG waveform information using orthonormal basis functions derived from body surface potential maps.

    abstract：:A common basis of orthogonal waveform functions was derived from 128 lead body surface potential maps of 405 subjects. Twelve such orthogonal functions or frames were adequate for reconstruction of original ECGs from the beginning of QRS to the end of T. A larger number of frames (18) was required when basis functions...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(85)80016-9

    authors： Kornreich F,Rautaharju PM,Warren JW,Horacek BM,Dramaix M

    更新日期：1985-10-01 00:00:00

  • Effect of electrolyte and pH changes on the sinus node pacemaking in humans.

    abstract：:The importance of plasma electrolytes and pH levels in determining heart rate is not yet well grounded. Hemodynamic and biochemical data were collected during 8 purely diffusive hemodialysis, which allowed changes in extracellular fluid to be achieved without eliciting notable changes in the autonomic control of heart...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1054/jelc.2002.31819

    authors： Severi S,Cavalcanti S,Mancini E,Santoro A

    更新日期：2002-04-01 00:00:00

  • His bundle electrogram recording using a multipolar electrode catheter via the arm veins.

    abstract：:In eighteen patients with atrioventricular conduction disturbance, His bundle electrograms were studied via the arm vein. A 6F Berkovits-Castellanos USCI hexapolar electrode catheter was introduced into the right atrium and looped across the tricuspid valve in a "golf club" shape. The main aim was to leave the two dis...

    journal_title：Journal of electrocardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-0736(81)80046-5

    authors： Giuffrida G,Critelli G,Giudice P,Miceli D,Betocchi S,Mazza F,Chiariello M,Condorelli M

    更新日期：1981-01-01 00:00:00