Abstract:
OBJECTIVE:This study was undertaken to evaluate the nature and onset of changes in the QRS complex in the offspring of patients with diabetes mellitus (DM) and metabolic syndrome (MetS). METHODS AND METHODS:A total of 529 subjects, divided into 5 groups, were included in the study: (i) group DM (n = 92), patients with DM; (ii) group MetS (n = 125), patients with MetS; (iii) group O-DM (n = 109), offspring of patients with DM; (iv) group O-MetS (n = 122), offspring of patients with MetS; and (v) group HO (n = 81), offspring of healthy subjects. QRS parameters analyzed included amplitude, maximum QRS spatial vector magnitude, electrical axis (EA), and 3 electrocardiogram (ECG) criteria for left ventricular hypertrophy based on amplitude criteria: Sokolow-Lyon index, Cornell voltage, and Gubner criterion. RESULTS:Patients with DM and MetS showed a significant leftward shift of the EA when compared with the control group. A modest but significant leftward shift of EA was also observed in both offspring groups. These EA and maximum QRS spatial vector magnitude changes were reflected in the individual leads of the 12-lead ECG. The prevalence of a positive diagnosis by accepted electrocardiographic criteria (ECG left ventricular hypertrophy) was low. CONCLUSION:Patients with DM and MetS displayed significant changes in QRS complex that suggest depolarization sequence deterioration. Similar changes were observed also in the offspring of patients with DM and MetS, which suggests early subclinical cardiovascular damage. These findings have implications for prevention, early diagnosis, and treatment in the offspring of patients with DM and MetS.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Bacharova L,Krivosikova Z,Wsolova L,Gajdos Mdoi
10.1016/j.jelectrocard.2012.02.004subject
Has Abstractpub_date
2012-05-01 00:00:00pages
244-51issue
3eissn
0022-0736issn
1532-8430pii
S0022-0736(12)00057-Xjournal_volume
45pub_type
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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doi:10.1016/s0022-0736(96)80073-2
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journal_title:Journal of electrocardiology
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abstract::VPC morphology was studied in the surface 12-leads ECGs (resting) in one hundred and thirty-six patients over a none-month period (January-September, 1978). Seventy four (54%) of these had coronary artery disease proven by cardiac catheterization (61) or by evidence of acute transmural myocardial infarction (13) diagn...
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2012.04.001
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2005.06.036
更新日期:2005-10-01 00:00:00
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journal_title:Journal of electrocardiology
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doi:10.1016/0022-0736(89)90024-1
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abstract::The American College of Cardiology recommends that patients with high risk acute myocardial infarction (AMI) be triaged to hospitals with percutaneous transluminal coronary angioplasty capability. However, there are no prehospital triage criteria to select candidates for bypassing community hospitals and being taken d...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1054/jelc.2000.20299
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2004.09.007
更新日期:2005-01-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(85)80016-9
更新日期:1985-10-01 00:00:00
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journal_title:Journal of electrocardiology
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更新日期:2007-11-01 00:00:00
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journal_title:Journal of electrocardiology
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doi:10.1016/0022-0736(90)90073-b
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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更新日期:2001-01-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2012.11.013
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2013.02.005
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journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
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