Abstract：
INTRODUCTION:Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS). METHODS:In pigs, myocardial infarction was induced by inflation of an angioplasty balloon in the left descending artery (LAD), and ECG was continuously recorded. QRS duration was calculated on a beat-to-beat basis during the occlusion period. Single photon emission computed tomography (SPECT) was performed for the assessment of MaR, and IS was assessed by magnetic resonance imaging (MRI). RESULTS:All animals developed an anteroseptal infarction with MaR 40±9% and IS 23±7%. Two peaks of QRS widening were found in all animals: the early peak immediately after LAD occlusion and the late one 17.7±4.1min later. No association was found between MaR and IS and either QRS width or the degree of QRS widening at the early peak. QRS duration on the late peak correlated with both MaR (r=0.61; p=0.007) and IS (r=0.55; p=0.018). CONCLUSION:The QRS widening at the late peak, but not at the early peak, is associated with the size of myocardial injury, suggesting different underlying mechanisms.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Demidova MM,Martín-Yebra A,Koul S,Engblom H,Martínez JP,Erlinge D,Platonov PGdoi
10.1016/j.jelectrocard.2016.03.014subject
Has Abstractpub_date
2016-05-01 00:00:00pages
300-6issue
3eissn
0022-0736issn
1532-8430pii
S0022-0736(16)00095-9journal_volume
49pub_type
杂志文章abstract：BACKGROUND:Hibernating myocardium develops inhomogeneity in myocardial sympathetic innervation with spontaneous sudden cardiac death (SCD) because of ventricular fibrillation (VF). The triggers and prodromal arrhythmias initiating SCD in this substrate are unknown. METHODS:Swine chronically instrumented with a proxima...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2006.05.026
更新日期：2006-10-01 00:00:00
abstract：:The contributions of reduced conduction velocity (CV) and prolonged action potential duration (APD) to QT interval prolongation and T wave and T vector loop morphology in left ventricular hypertrophy (LVH) were studied using an analytical computer model. Three types of anatomic LVH were simulated: concentric and eccen...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.07.005
更新日期：2010-11-01 00:00:00
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journal_title：Journal of electrocardiology
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doi：10.1016/s0022-0736(99)90005-5
更新日期：1999-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2017.09.009
更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(78)80107-1
更新日期：1978-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(83)80004-1
更新日期：1983-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2017.09.004
更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.08.008
更新日期：2011-03-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2011.03.010
更新日期：2011-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(81)80044-1
更新日期：1981-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2012.07.010
更新日期：2012-11-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2003.10.003
更新日期：2004-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2004.08.056
更新日期：2004-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2018.09.006
更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(94)80001-4
更新日期：1994-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(80)80039-2
更新日期：1980-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/s0022-0736(00)80106-5
更新日期：2000-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(80)80051-3
更新日期：1980-04-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(80)80017-3
更新日期：1980-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2013.10.001
更新日期：2014-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
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更新日期：1979-10-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2001.28810
更新日期：2001-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(96)80082-3
更新日期：1996-07-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2015.06.009
更新日期：2015-09-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2020.02.002
更新日期：2020-01-01 00:00:00
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journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2019.05.005
更新日期：2019-01-01 00:00:00
