Abstract:
:Hypertrophic cardiomyopathy (HCM) have been reported to display impaired heart rate variability, although little is known regarding its prognostic value. By using fast Fourier transformation of 24-hour Holter recordings in 73 HCM patients at a stable clinical condition, we computed 4 spectral components: very low frequency, low frequency, high frequency, and total power. During 28 months, 7 HCM patients experienced death or acquired hospitalization for heart failure. Sudden death did not occurred. High frequency component was lower in HCM patients with cardiac events than that in patients without cardiac events (3.78 +/- 0.66 vs. 4.43 +/- 0.92 In(ms(2)), P =.045). There were no significant differences in other heart rate variability variables between HCM patients with and without cardiac events. In multivariate analysis, high frequency component remained to be an independent predictor of cardiac events (relative risk=0.10, 95% CI 0.01-0.73, P =.023). Heart rate variability analysis is predictive of heart failure in our cohort of HCM patients, whereas its predictive value of sudden death remains unclear.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Kawasaki T,Azuma A,Sakatani T,Hadase M,Kamitani T,Kawasaki S,Kuribayashi T,Sugihara Hdoi
10.1016/j.jelectrocard.2003.08.005keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
333-8issue
4eissn
0022-0736issn
1532-8430pii
S0022073603000864journal_volume
36pub_type
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