Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.

abstract：:Variants of A/PR/8/34 (HON1) influenza virus, having hemagglutinin molecules with probably a single altered antigenic determinant, were isolated by growing the virus in the presence of the monoclonal hybridoma antibody PEG-1. The variants were analyzed by peptide mapping and characterized antigenically by using PEG-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laver WG,Gerhard W,Webster RG,Frankel ME,Air GM

更新日期：1979-03-01 00:00:00

abstract：:Daytime sleepiness impairs cognitive ability, but recent evidence suggests it is also an important driver of human motivation and behavior. We aimed to investigate the relationship between sleepiness and a behavior strongly associated with better health: social activity. We additionally aimed to investigate whether a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holding BC,Sundelin T,Schiller H,Åkerstedt T,Kecklund G,Axelsson J

更新日期：2020-09-01 00:00:00

abstract：:Tactile-foraging ducks are specialist birds known for their touch-dependent feeding behavior. They use dabbling, straining, and filtering to find edible matter in murky water, relying on the sense of touch in their bill. Here, we present the molecular characterization of embryonic duck bill, which we show contains a h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider ER,Anderson EO,Mastrotto M,Matson JD,Schulz VP,Gallagher PG,LaMotte RH,Gracheva EO,Bagriantsev SN

更新日期：2017-12-05 00:00:00

abstract：:The influenza virus genes that confer efficient transmission of epidemic and pandemic strains in humans have not been identified. The rapid spread and severe disease caused by the 1918 influenza pandemic virus makes it an ideal virus to study the transmissibility of potentially pandemic influenza strains. Here, we use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Hoeven N,Pappas C,Belser JA,Maines TR,Zeng H,García-Sastre A,Sasisekharan R,Katz JM,Tumpey TM

更新日期：2009-03-03 00:00:00

abstract：:Type 2 diabetes is preceded by the development of insulin resistance, in which the action of insulin is impaired, largely in skeletal muscles. Caveolin-3 (Cav3) is a muscle-specific subtype of caveolin, an example of a scaffolding protein found within membranes. Cav is also known as growth signal inhibitor, although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oshikawa J,Otsu K,Toya Y,Tsunematsu T,Hankins R,Kawabe J,Minamisawa S,Umemura S,Hagiwara Y,Ishikawa Y

更新日期：2004-08-24 00:00:00

abstract：:III-V compound semiconductors are widely used for electronic and optoelectronic applications. However, interfacing III-Vs with other materials has been fundamentally limited by the high growth temperatures and lattice-match requirements of traditional deposition processes. Recently, we developed the templated liquid-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hettick M,Li H,Lien DH,Yeh M,Yang TY,Amani M,Gupta N,Chrzan DC,Chueh YL,Javey A

更新日期：2020-01-14 00:00:00

abstract：:Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus are useful tools for in vivo cancer imaging. Photodynamic therapy (PDT) is a cell-killing process by light activation of a photosensitizer (PS) in the presence of oxygen....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Chen J,Stefflova K,Jarvi M,Li H,Wilson BC

更新日期：2007-05-22 00:00:00

abstract：:Animals and plants use modified cell cycles to achieve particular developmental strategies. In one common example, most animals and plants have tissues in which the cells become polyploid or polytene by means of an S-G cycle, but the mechanism by which mitosis is inhibited in the endo cycle is not understood. The Dros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kashevsky H,Wallace JA,Reed BH,Lai C,Hayashi-Hagihara A,Orr-Weaver TL

更新日期：2002-08-20 00:00:00

abstract：:A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freedman ML,Haiman CA,Patterson N,McDonald GJ,Tandon A,Waliszewska A,Penney K,Steen RG,Ardlie K,John EM,Oakley-Girvan I,Whittemore AS,Cooney KA,Ingles SA,Altshuler D,Henderson BE,Reich D

更新日期：2006-09-19 00:00:00

abstract：:Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient. Four electrons and protons are used for chemistry, while four more protons are pumped. Proton pumping requires that residues on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu J,Gunner MR

更新日期：2014-08-26 00:00:00

abstract：:Two-component signal transduction systems are most often found in prokaryotic organisms where they are responsible for mediating the cellular responses to many environmental stimuli. These systems are composed of an autophosphorylating histidine kinase and a response regulator. We have found evidence for the existence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alex LA,Borkovich KA,Simon MI

更新日期：1996-04-16 00:00:00

abstract：:Inflammation is a hallmark of many diseases, such as atherosclerosis, chronic obstructive pulmonary disease, arthritis, infectious diseases, and cancer. Although steroids and cyclooxygenase inhibitors are effective antiinflammatory therapeutical agents, they may cause serious side effects. Therefore, developing unique...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeon KI,Xu X,Aizawa T,Lim JH,Jono H,Kwon DS,Abe J,Berk BC,Li JD,Yan C

更新日期：2010-05-25 00:00:00

abstract：:Molecular cloning has demonstrated a diversity of artificially expressed N-methyl-D-aspartate (NMDA) receptors, implying a similar diversity of naturally occurring NMDA receptors in situ. Particularly significant was the success in expression of NMDA receptor classes exhibiting various sensitivities to Mg2+ block, a v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato N,Yoshimura H

更新日期：1993-08-01 00:00:00

abstract：:Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: (i) pretreatment with reversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitation of GABA(A) receptor signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pibiri F,Kozikowski AP,Pinna G,Auta J,Kadriu B,Costa E,Guidotti A

更新日期：2008-09-16 00:00:00

abstract：:Specific viral transformation rather than cell selection can explain the previously observed increase in the proportion of type III procollagen compared to type I procollagen in BALB 3T3 cells transformed by Kirsten murine sarcoma virus (Ki-MSV). Two subclones of BALB 3T3 A31 were productively infected with with a tem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bateman JF,Peterkofsky B

更新日期：1981-10-01 00:00:00

abstract：:Biologists regularly search databases of DNA or protein sequences for evolutionary or functional relationships to a given query sequence. We describe a ranking algorithm that exploits the entire network structure of similarity relationships among proteins in a sequence database by performing a diffusion operation on a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weston J,Elisseeff A,Zhou D,Leslie CS,Noble WS

更新日期：2004-04-27 00:00:00

abstract：:Regulatory T cells (Treg) comprise multiple subsets and are important in controlling immunity and inflammation. However, the induction and mode of action of the various distinct Treg subsets remain ill defined, particularly in humans. Here, we describe a human CD8+ lymphocyte activation gene-3 (LAG-3)+CD25+FoxP3+ Treg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joosten SA,van Meijgaarden KE,Savage ND,de Boer T,Triebel F,van der Wal A,de Heer E,Klein MR,Geluk A,Ottenhoff TH

更新日期：2007-05-08 00:00:00

abstract：:Electron microscopic techniques have been used to reveal two classes of subunits of tubulin in ordered arrays. Presumably the two classes correspond to the alpha and beta polypeptide chains of tubulin that have been distinguished by chemical criteria. The two types of subunits alternate along individual protofilaments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crepeau RH,McEwen B,Edelstein SJ

更新日期：1978-10-01 00:00:00

abstract：:Interstitial telomeric sequences (ITSs) are present in many eukaryotic genomes and are linked to genome instabilities and disease in humans. The mechanisms responsible for ITS-mediated genome instability are not understood in molecular detail. Here, we use a model Saccharomyces cerevisiae system to characterize genome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aksenova AY,Greenwell PW,Dominska M,Shishkin AA,Kim JC,Petes TD,Mirkin SM

更新日期：2013-12-03 00:00:00

abstract：:The prediction of interresidue contacts and distances from coevolutionary data using deep learning has considerably advanced protein structure prediction. Here, we build on these advances by developing a deep residual network for predicting interresidue orientations, in addition to distances, and a Rosetta-constrained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Anishchenko I,Park H,Peng Z,Ovchinnikov S,Baker D

更新日期：2020-01-21 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor pathway has not been fully demonstrated. In this paper, we report that NPB-deficient mice manifest a mild adult-onset obesit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly MA,Beuckmann CT,Williams SC,Sinton CM,Motoike T,Richardson JA,Hammer RE,Garry MG,Yanagisawa M

更新日期：2005-07-12 00:00:00

abstract：:Many synthetic or natural fibers are produced via the transformation of a liquid solution into a solid filament, which allows the wet processing of high molecular weight polymers, proteins, or inorganic particles. Synthetic wet-spun fibers are used in our everyday life from clothing to composite reinforcement applicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercader C,Lucas A,Derré A,Zakri C,Moisan S,Maugey M,Poulin P

更新日期：2010-10-26 00:00:00

abstract：:Fibronectin mediates the adhesion of cells to collagen by first binding to the collagen substrate, followed by attachment of the cells to the fibronectin-collagen complex. Bovine brain gangliosides were found to block fibronectin-mediated cell adhesion to collagen in a concentration-dependent manner. The gangliosides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinman HK,Martin GR,Fishman PH

更新日期：1979-07-01 00:00:00

abstract：:Among yeasts that underwent whole-genome duplication (WGD), Kluyveromyces polysporus represents the lineage most distant from Saccharomyces cerevisiae. By sequencing the K. polysporus genome and comparing it with the S. cerevisiae genome using a likelihood model of gene loss, we show that these species diverged very s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scannell DR,Frank AC,Conant GC,Byrne KP,Woolfit M,Wolfe KH

更新日期：2007-05-15 00:00:00

abstract：:Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use of syringe and needle, mucosal vaccination is considered ideal for the global control of infectious diseases. In this study, we developed a rice-based oral vaccine expressing cholera toxin B subunit (CTB) un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nochi T,Takagi H,Yuki Y,Yang L,Masumura T,Mejima M,Nakanishi U,Matsumura A,Uozumi A,Hiroi T,Morita S,Tanaka K,Takaiwa F,Kiyono H

更新日期：2007-06-26 00:00:00

abstract：:The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, conferring tumor development and survival. Antagonists targeting the p53-binding domains of MDM2 and MDMX kill tumor cells both in vitro and in vivo by reactivating the p53 pathway, promising a class of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Li C,Pazgier M,Li C,Mao Y,Lv Y,Gu B,Wei G,Yuan W,Zhan C,Lu WY,Lu W

更新日期：2010-08-10 00:00:00

abstract：:The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL-derived mRNA transcripts that can substitute for IL3 signaling. We demonstrate that CRL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoda A,Yoda Y,Chiaretti S,Bar-Natan M,Mani K,Rodig SJ,West N,Xiao Y,Brown JR,Mitsiades C,Sattler M,Kutok JL,DeAngelo DJ,Wadleigh M,Piciocchi A,Dal Cin P,Bradner JE,Griffin JD,Anderson KC,Stone RM,Ritz J,Foà R,

更新日期：2010-01-05 00:00:00

abstract：:We used positron emission tomography (PET) to examine the role of the hippocampal formation in implicit and explicit memory. Human volunteers studied a list of familiar words, and then they either provided the first word that came to mind in response to three-letter cues (implicit memory) or tried to recall studied wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schacter DL,Alpert NM,Savage CR,Rauch SL,Albert MS

更新日期：1996-01-09 00:00:00

abstract：:Heat shock locus V (HslV; also called ClpQ) is the proteolytic core of the ATP-dependent protease HslVU in Escherichia coli. It has sequence similarity with the beta-type subunits of the eukaryotic and archaebacterial proteasomes. Unlike these particles, which display 72-point symmetry, it is a dimer of hexamers with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochtler M,Ditzel L,Groll M,Huber R

更新日期：1997-06-10 00:00:00

abstract：:The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon assembly of the alpha/beta-tubulin heterodimer, GTP bound to beta-tubulin is hydrolyzed to GDP reaching a steady-state equilibrium between free tubulin dimers and microtubules. The binding of Ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao H,Verdier-Pinard P,Fernandez-Fuentes N,Burd B,Angeletti R,Fiser A,Horwitz SB,Orr GA

更新日期：2006-07-05 00:00:00