Abstract：
:ABSTRACT A report of neuroleptic malignant syndrome (NMS) in an adolescent patient with bipolar disorder is presented, and findings from a literature review of 35 child and adolescent cases (presenting before age 19) are compared with the reported experience in adults. Fever, rigidity, altered mental status, and tachycardia were observed in more than 70% of cases, and symptoms closely follow the patient's exposure to neuroleptic medications. A majority of the patients were being treated with a high-potency neuroleptic agent and often with more than a single drug. Schizophrenia and bipolar disorder were the most common diagnoses. Neither gender predominates the sample, and adjunctive lithium therapy does not appear to be a significant factor in the genesis of this syndrome in children. Eighty-one percent of the patients recovered, with the majority of patients treated with supportive measures, discontinuation of medications, and adjunctive pharmacotherapy. Only 9 patients were treated with supportive measures alone, and electroconvulsive treatment (ECT) was successfully used in 3 patients. Six patients were reported to have been successfully rechallenged with neuroleptic medications. NMS should be considered in any child with a combination of unexplained fever, rigidity, signs of autonomic dysfunction, changes in mental status, and a history of neuroleptic exposure.
journal_name
J Child Adolesc Psychopharmacoljournal_title
Journal of child and adolescent psychopharmacologyauthors
Steingard R,Khan A,Gonzalez A,Herzog DBdoi
10.1089/cap.1992.2.183subject
Has Abstractpub_date
1992-10-01 00:00:00pages
183-98issue
3eissn
1044-5463issn
1557-8992journal_volume
2pub_type
杂志文章abstract：:Data on risperidone's efficacy and tolerability in adolescents with schizophrenia are scarce. We found only one prospective, open-label study in this population. The aim of this open-label, prospective study was to estimate the effectiveness, safety, and tolerability of risperidone treatment in adolescents with first-...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1089/104454603322572651
更新日期：2003-10-01 00:00:00
abstract：:The potential for the induction of mania, increased cycle frequency, and other behavioral adverse events associated with antidepressant exposure in patients with bipolar disorder is becoming an increasingly important area of research study, as this diagnosis receives wider recognition in youth. While the majority of s...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,评审
doi：10.1089/104454603322163880
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Prior studies have suggested that inhibited temperament may be associated with an increased risk for developing anxiety or mood disorder, including bipolar disorder. However, the neurobiological basis for this increased risk is unknown. The aim of this study was to examine temperament in symptomatic and asym...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2016.0086
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Despite its high chronicity, few studies have evaluated the effectiveness of long-term treatment for pediatric obsessive-compulsive disorder (OCD). The goal of the current analysis is to evaluate remission among children and adolescents with OCD treated with sertraline for 12 months. METHODS:Children (6-12 ...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1089/104454603322126340
更新日期：2003-01-01 00:00:00
abstract：:In clinical samples, juvenile bipolar disorder (JBPD) is frequently accompanied by co-morbid attention-deficit/hyperactivity disorder (ADHD). Clinical trials assessing combined psychopharmacological interventions in this population are scarce, and methylphenidate (MPH) may worsen manic symptoms. We conducted a randomi...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1089/cap.2009.0037
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To assess the effect of Osmotic-Release Oral System (OROS) methylphenidate (MPH) on a variety of measures evaluating academic performance, cognition, and social behavior in children with attention-deficit/hyperactivity disorder (ADHD). METHODS:This double-blind, randomized, placebo-controlled, crossover labo...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/cap.2010.0047
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:The purpose of this article was to examine whether injuries in early childhood and gender predict prescriptions of stimulant medication in three groups of children: With attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and other psychiatric disorders (OPD). METHODS:This was a ...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2013.0101
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The use of atypical antipsychotics is increasing in adolescent populations, but little is known about adherence with these treatments. This study examined postdischarge adherence of adolescents treated as inpatients with either olanzapine or risperidone. METHODS:Eighty-six (86) adolescent inpatients (43 per...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2005.15.901
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:The use of methylphenidate (MPH) in the treatment of attention-deficit/hyperactivity disorder (ADHD) is widely accepted; however, there is increased concern regarding its abuse potential. Few studies have examined the reinforcing effects of drugs in individuals receiving them for clinical purposes. This study...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1089/cap.2005.15.729
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVES:Studies have primarily focused on adverse life events (ALEs) as potential causes rather than as outcomes of pediatric depression. The current study prospectively examines ALEs in a sample of youth with attention-deficit/hyperactivity disorders (ADHD) to determine whether having a major depressive disorder (M...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2011.0046
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:In the four-site Treatment of Severe Childhood Aggression (TOSCA) study, addition of risperidone to stimulant and parent training moderately improved parent-rated disruptive behavior disorder (DBD) symptoms. This secondary study explores outcomes other than DBD and attention-deficit/hyperactivity disorder (AD...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1089/cap.2014.0104
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:The antipsychotic drugs are the best-studied agents shown to reduce symptoms in autism, including hyperactivity, aggression, self-abusive behavior, temper tantrums, lability, irritability, social withdrawal, and stereotypical behaviors. However, significant weight gain has been associated with use of many ...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2006.0126
更新日期：2007-12-01 00:00:00
abstract：:The prevalence and treatment of behavioral and mental illnesses in the adolescent population are increasing, and many of the medications used are continued into adulthood. Increased vigilance is necessary when caring for this population to prevent side effects and drug interactions. In this short communication, we pre...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2005.15.693
更新日期：2005-08-01 00:00:00
abstract：:In the last 15 years, there has been a marked increase in the number of available stimulant formulations with the emphasis on long-acting formulations, and the introduction of several novel delivery systems such as orally dissolving tablets, chewable tablets, extended-release liquid formulations, transdermal patches, ...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,评审
doi：10.1089/cap.2019.0043
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects. These risks are perceived by some clinicians to be greater in substance-abusing adolescents relative to non-substance-abusing adults...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1089/cap.2011.0014
更新日期：2011-10-01 00:00:00
abstract：:The selective serotonin reuptake inhibitors (SSRIs) are becoming widely used in children and adolescents, with possible unexpected side effects being observed over time. SSRIs have been associated with bleeding in adults who have unremarkable routine hematologic laboratory results except abnormal bleeding time or plat...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2000.10.35
更新日期：2000-04-01 00:00:00
abstract：: Objective: Pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) are emerging immune-mediated encephalopathies characterized by sudden onset of seemingly inexplica...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2018.0151
更新日期：2019-10-01 00:00:00
abstract：:Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient cli...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2010.0103
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Concerns about serious cardiovascular (CV) events among stimulant-treated youth have led to clinical and policy debates. Accordingly, several population-based empirical studies have assessed the risk of CV events in children and adolescents treated with stimulants. The main objective of this review was to sum...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,评审
doi：10.1089/cap.2015.0239
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Weight gain due to the use of second-generation antipsychotics is a major health care issue for adult and paediatric psychiatric patients. Little is known about long-term weight gain effects of aripiprazole compared to risperidone in children and adolescents. OBJECTIVE:The primary aim of this study is to as...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2018.0111
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to identify predictors of pill placebo response and to characterize the temporal course of pill placebo response in anxious youth. METHODS:Data from placebo-treated patients (N = 76) in the Child/Adolescent Anxiety Multimodal Study (CAMS), a multisite, randomized controlled trial th...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1089/cap.2016.0198
更新日期：2017-08-01 00:00:00
abstract：: Objective: To guide clinicians in selecting the "next line" selective serotonin reuptake inhibitor (SSRI) for adolescents with treatment-resistant major depressive disorder, we sought to compare response rates among SSRIs in the Treatment of SSRI-Resistant Depression in Ad...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2018.0145
更新日期：2019-05-01 00:00:00
abstract：:Children and adolescents with bipolar disorder (BD) have a high incidence of comorbid attention-deficit/hyperactivity disorder (ADHD). In this paper, we report a consecutive case series on 7 patients with pediatric BD and ADHD who were treated with atomoxetine-and all but one were also treated in conjunction with mood...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2005.15.996
更新日期：2005-12-01 00:00:00
abstract：:Treatment with psychostimulant medication has been shown to improve scholastic functioning in children with attention-deficit/hyperactivity disorder (ADHD). However, the extent to which long-term academic gains are apparent in those having received such treatment remains elusive. This study examined prospectively the ...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2008.021
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To examine fatty acid profiles, their response to omega-3 fatty acid (Ω3) supplementation, and associations with clinical status and treatment response in youth with mood disorders. METHODS:In a placebo-controlled 2X2 design, 7-14 year-olds (N = 95) in parallel pilot trials (depression N = 72; bipolar N = 23...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1089/cap.2016.0123
更新日期：2017-04-01 00:00:00
abstract：:This open-label study examined the potential efficacy of paroxetine in the treatment of children and adolescents diagnosed with dysthymia over a period of 3 months. Seven subjects were evaluated by the Hamilton Depression Rating Scale (HAM-D), by the Clinical Global Impression Severity of Illness Scale (CGI-S), and th...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1089/cap.2000.10.103
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). METHOD:Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or wer...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1089/cap.2009.0035
更新日期：2009-12-01 00:00:00
abstract：: Objective: To examine the role of Guanfacine Extended Release (GXR) in the management of behavioral disturbances in patients with Prader-Willi Syndrome (PWS). Methods: Twenty from a total of 27 individuals with genetically conf...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2018.0102
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to assess long-term improvement in quality of life (QOL) in adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with lisdexamfetamine dimesylate (LDX). METHODS:Adolescents with ADHD treated for ≥3 weeks in a 4 week, placebo-controlled study entered a 1 year...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1089/cap.2013.0077
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:Impulsive-aggressive behaviors have been consistently implicated in the phenomenology, neurobiology, and familial aggregation of suicidal behavior. The purpose of this study was to extend previous work by examining laboratory behavioral measures of delayed reward impulsivity and impulsive aggression in adoles...
journal_title：Journal of child and adolescent psychopharmacology
pub_type： 杂志文章
doi：10.1089/cap.2014.0042
更新日期：2015-03-01 00:00:00
