Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence.

Abstract:

:The selective serotonin reuptake inhibitors (SSRIs) are becoming widely used in children and adolescents, with possible unexpected side effects being observed over time. SSRIs have been associated with bleeding in adults who have unremarkable routine hematologic laboratory results except abnormal bleeding time or platelet counts in few cases. Given the increase of pediatric SSRI prescriptions, in this article we describe five children, ages 8 through 15, who developed bruising or epistaxis 1 week to 3 months after starting SSRI treatment. It is possible that the effects SSRI on platelet functioning are causing the bleeding observed in some patients and/or that a separate coagulopathy is present and contributing to bleeding. The subject matter deserves future investigation.

authors

Lake MB,Birmaher B,Wassick S,Mathos K,Yelovich AK

doi

10.1089/cap.2000.10.35

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

35-8

issue

1

eissn

1044-5463

issn

1557-8992

journal_volume

10

pub_type

杂志文章
  • Participant-perceived quality of life in a long-term, open-label trial of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVES:The purpose of this study was to assess long-term improvement in quality of life (QOL) in adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with lisdexamfetamine dimesylate (LDX). METHODS:Adolescents with ADHD treated for ≥3 weeks in a 4 week, placebo-controlled study entered a 1 year...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2013.0077

    authors: Childress AC,Cutler AJ,Saylor K,Gasior M,Hamdani M,Ferreira-Cornwell MC,Findling RL

    更新日期:2014-05-01 00:00:00

  • A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism.

    abstract::Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient cli...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0103

    authors: Fung LK,Chahal L,Libove RA,Bivas R,Hardan AY

    更新日期:2012-06-01 00:00:00

  • Impact of regulatory safety warnings on the use of antidepressants among children and adolescents in Finland.

    abstract:OBJECTIVE:The aim of this study was to analyze changes in the prevalence and incidence of antidepressant use among children and adolescents in Finland post October, 2003. METHOD:The sample comprised all children and adolescents in Finland aged < or =19.0 years (n = 27,676) who collected one or more reimbursed prescrip...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2009.0040

    authors: Foulon V,Svala A,Koskinen H,Chen TF,Saastamoinen LK,Bell JS

    更新日期:2010-04-01 00:00:00

  • Preliminary study of relationships among measures of depressive symptoms in adolescents with bipolar disorder.

    abstract:PURPOSE:The aim of this study was to explore relationships between the Children's Depression Rating Scale-Revised (CDRS-R) and Hamilton Rating Scale for Depression (HAM-D) in adolescent bipolar disorder. We hypothesized that CDRS-R and HAM-D scores would be significantly correlated and both scales would be sensitive to...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.16.327

    authors: Patel NC,DelBello MP,Kowatch RA,Strakowski SM

    更新日期:2006-06-01 00:00:00

  • Assessment of core competencies in childhood attention-deficit/hyperactivity disorder practice.

    abstract::The study assessed competencies and practices of a large group of healthcare providers in childhood attention-deficit/hyperactivity disorder (ADHD), and identified barriers to improving care. Methods were self-assessment using an Internet questionnaire with a standardized patient case; analysis compared with professio...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0029

    authors: Brown JJ,Hertzer JL,Findling RL

    更新日期:2011-02-01 00:00:00

  • Effectiveness, safety, and tolerability of risperidone in adolescents with schizophrenia: an open-label study.

    abstract::Data on risperidone's efficacy and tolerability in adolescents with schizophrenia are scarce. We found only one prospective, open-label study in this population. The aim of this open-label, prospective study was to estimate the effectiveness, safety, and tolerability of risperidone treatment in adolescents with first-...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/104454603322572651

    authors: Zalsman G,Carmon E,Martin A,Bensason D,Weizman A,Tyano S

    更新日期:2003-10-01 00:00:00

  • Efficacy, long-term safety, and tolerability of ziprasidone in children and adolescents with bipolar disorder.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the short- and long-term efficacy and safety of ziprasidone in children and adolescents with bipolar I disorder. METHODS:Subjects 10-17 years of age with a manic or mixed episode associated with bipolar I disorder participated in a 4 week, randomized, double-blind, p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2012.0029

    authors: Findling RL,Cavuş I,Pappadopulos E,Vanderburg DG,Schwartz JH,Gundapaneni BK,DelBello MP

    更新日期:2013-10-01 00:00:00

  • Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series.

    abstract::Attention-deficit hyperactivity disorder (ADHD) and major depression are common ailments that can cause significant dysfunction throughout the life cycle. These two disorders may occur comorbidly. This case series describes 7 pediatric patients (aged 10-16 years) and 4 adults (aged 38-44 years) whose ADHD and comorbid...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.165

    authors: Findling RL

    更新日期:1996-10-01 00:00:00

  • Placebo Response in Pediatric Anxiety Disorders: Implications for Clinical Trial Design and Interpretation.

    abstract:OBJECTIVES:The characterization and prediction of placebo response in clinical trials of youth with anxiety disorders have received little attention, despite the critical effects of placebo response rate on the success or failure of clinical trials. With this in mind, we sought to examine the factors that predict or in...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2015.0192

    authors: Dobson ET,Strawn JR

    更新日期:2016-10-01 00:00:00

  • Screening for adolescent depression: comparison of the Kutcher Adolescent Depression Scale with the Beck depression inventory.

    abstract::Self-report instruments commonly used to assess depression in adolescents have limited or unknown reliability and validity in this age group. We describe a new self-report scale, the Kutcher Adolescent Depression Scale (KADS), designed specifically to diagnose and assess the severity of adolescent depression. This rep...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/104454602760219153

    authors: LeBlanc JC,Almudevar A,Brooks SJ,Kutcher S

    更新日期:2002-07-01 00:00:00

  • Impulsive aggression, delay discounting, and adolescent suicide attempts: effects of current psychotropic medication use and family history of suicidal behavior.

    abstract:OBJECTIVE:Impulsive-aggressive behaviors have been consistently implicated in the phenomenology, neurobiology, and familial aggregation of suicidal behavior. The purpose of this study was to extend previous work by examining laboratory behavioral measures of delayed reward impulsivity and impulsive aggression in adoles...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2014.0042

    authors: Bridge JA,Reynolds B,McBee-Strayer SM,Sheftall AH,Ackerman J,Stevens J,Mendoza K,Campo JV,Brent DA

    更新日期:2015-03-01 00:00:00

  • Successful Use of Sertindole for Severe Behavioral Dyscontrol in a Pediatric Case of Syndromic Autism Spectrum Disorder.

    abstract::Autism spectrum disorder (ASD) is commonly associated with a host of challenging behaviors. Pharmacotherapy is indicated if psychosocial and educational interventions fail. Atypical antipsychotics have the strongest evidence base so far, with both risperidone and aripiprazole being FDA approved. Unfortunately, their u...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2016.0182

    authors: Naguy A

    更新日期:2017-06-01 00:00:00

  • The Importance of Second-Generation Antipsychotic-Related Weight Gain and Adherence Barriers in Youth with Bipolar Disorders: Patient, Parent, and Provider Perspectives.

    abstract:: Objectives: The objective of this research was to understand physician, patient, and parent perspectives on barriers to second-generation antipsychotic (SGA) medication adherence in youth with bipolar spectrum disorders, and attitudes toward treatment of SGA-related weight...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2019.0184

    authors: Klein CC,Topalian AG,Starr B,Welge J,Blom T,Starr C,Deetz I,Turner H,Sage J,Utecht J,Fornari V,Patino Duran L,Higdon C,Sutton JJ,Sorter MT,Correll CU,DelBello MP

    更新日期:2020-07-01 00:00:00

  • The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder.

    abstract:OBJECTIVES:Previous studies have suggested that the sum of Attention, Aggression, and Anxious/Depressed subscales of Child Behavior Checklist (CBCL-PBD; pediatric bipolar disorder phenotype) may be specific to pediatric bipolar disorder (BP). The purpose of this study was to evaluate the usefulness of the CBCL and CBCL...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2008.067

    authors: Diler RS,Birmaher B,Axelson D,Goldstein B,Gill M,Strober M,Kolko DJ,Goldstein TR,Hunt J,Yang M,Ryan ND,Iyengar S,Dahl RE,Dorn LD,Keller MB

    更新日期:2009-02-01 00:00:00

  • Standardized Observation Analogue Procedure in the Treatment of Severe Childhood Aggression Study.

    abstract:: Objective: To explore blinded observational outcomes in the Treatment of Severe Childhood Aggression (TOSCA) study. Methods: During a 9-week acute trial, children with severe physical aggression and attention-deficit/hyperactiv...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2019.0109

    authors: Grondhuis SN,Farmer CA,Arnold LE,Gadow KD,Findling RL,Molina BSG,Kolko DJ,Buchan-Page KA,Rice RR , Jr,Butter EM,Aman MG

    更新日期:2020-02-01 00:00:00

  • Neural correlates of treatment in adolescents with bipolar depression during response inhibition.

    abstract:OBJECTIVE:Abnormal prefrontal and subcortical activity during cognitive control tasks is identified in non-depressed adolescents with bipolar disorder (BD); however, little is known about the neural correlates of bipolar adolescents in a depressed state (BDd). We aimed to investigate baseline versus after-treatment pat...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2012.0054

    authors: Diler RS,Segreti AM,Ladouceur CD,Almeida JR,Birmaher B,Axelson DA,Phillips ML,Pan L

    更新日期:2013-04-01 00:00:00

  • Quetiapine monotherapy in adolescents with bipolar disorder comorbid with conduct disorder.

    abstract::Bipolar Disorders (BD) are often comorbid with disruptive behaviour disorders (DBDs) (oppositional-defiant disorder or conduct disorder), with negative implications on treatment strategy and outcome. The aim of this study was to assess the efficacy of quetiapine monotherapy in adolescents with BD comorbid with conduct...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2013.0063

    authors: Masi G,Pisano S,Pfanner C,Milone A,Manfredi A

    更新日期:2013-10-01 00:00:00

  • Antidepressant prescribing practices for the treatment of children and adolescents.

    abstract:OBJECTIVE:This study evaluates pediatric antidepressant prescribing practices of Nebraska clinicians. METHODS:Surveys were sent in July, 2005, to 1,521 prescribing clinicians throughout Nebraska to assess pediatric antidepressant use along with any practice changes following the U.S. Food and Drug Administration (FDA)...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0049

    authors: Bhatia SK,Rezac AJ,Vitiello B,Sitorius MA,Buehler BA,Kratochvil CJ

    更新日期:2008-02-01 00:00:00

  • Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study.

    abstract:OBJECTIVE:A recent 12-week controlled comparison demonstrated the superiority of clozapine to "high-dose" olanzapine in adolescents with treatment-refractory schizophrenia. In the present study, the authors conducted a 12-week, open-label, follow-up study to examine changes in lipid and glucose metabolism in youths mai...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2007.0089

    authors: Kumra S,Kranzler H,Gerbino-Rosen G,Kester HM,DeThomas C,Cullen K,Regan J,Kane JM

    更新日期:2008-08-01 00:00:00

  • Nutritional supplements and complementary/alternative medicine in Tourette syndrome.

    abstract:OBJECTIVE:Tourette syndrome (TS) is a neuropsychiatric disorder associated with motor and vocal tics. Some people with TS have reported using alternative or complementary medicine (CAM), including nutritional supplements to control their tics. In a recent national survey, approximately 40% of people reported having use...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2004.14.582

    authors: Mantel BJ,Meyers A,Tran QY,Rogers S,Jacobson JS

    更新日期:2004-01-01 00:00:00

  • The effect of fluvoxamine and behavior therapy on children and adolescents with obsessive-compulsive disorder.

    abstract:OBJECTIVE:The efficacy of medications, consisting of serotonin partial and specific reuptake blockers, and behavior therapy, consisting of exposure and response prevention in addition to social skills training, cognitive therapy, and habit reversal, in the treatment of obsessive-compulsive disorder are well documented....

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/cap.2000.10.295

    authors: Neziroglu F,Yaryura-Tobias JA,Walz J,McKay D

    更新日期:2000-01-01 00:00:00

  • Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation.

    abstract::This single case reports an open trial of lamotrigine in the treatment of self-injurious behavior (SIB) and epilepsy in an 18-year-old female diagnosed with generalized seizure disorder, stereotypic movement disorder, and compulsive SIB in the context of profound mental retardation. Animal models of SIB suggest that t...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.273

    authors: Davanzo PA,King BH

    更新日期:1996-01-01 00:00:00

  • Guanfacine Extended Release for the Reduction of Aggression, Attention-Deficit/Hyperactivity Disorder Symptoms, and Self-Injurious Behavior in Prader-Willi Syndrome-A Retrospective Cohort Study.

    abstract:: Objective: To examine the role of Guanfacine Extended Release (GXR) in the management of behavioral disturbances in patients with Prader-Willi Syndrome (PWS). Methods: Twenty from a total of 27 individuals with genetically conf...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0102

    authors: Singh D,Wakimoto Y,Filangieri C,Pinkhasov A,Angulo M

    更新日期:2019-05-01 00:00:00

  • The Pharmacoepidemiology of Psychotropic Medication Use in Canadian Children from 2012 to 2016.

    abstract:: Objective: The goal of this study was to characterize the frequency and trends of psychotropic drug prescribing in Canadian children from 2010 to 2016 and to compare these results with a previous study conducted between 2005 and 2009. Methods: ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2019.0018

    authors: Pringsheim T,Stewart DG,Chan P,Tehrani A,Patten SB

    更新日期:2019-12-01 00:00:00

  • Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine.

    abstract:OBJECTIVE:The aim of this study was to summarize results of a blinded review of potential suicidal events and analyses comparing incidence rates between paroxetine- and placebo-treated pediatric patients. METHOD:One thousand one hundred ninety-one (1191) children and adolescents received paroxetine (n = 642) or placeb...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2006.16.77

    authors: Apter A,Lipschitz A,Fong R,Carpenter DJ,Krulewicz S,Davies JT,Wilkinson C,Perera P,Metz A

    更新日期:2006-02-01 00:00:00

  • Obsessive-compulsive disorder secondary to brain dysgerminoma in an adolescent boy: a positron emission tomography case report.

    abstract::The neuroanatomical model involved in the pathophysiology of obsessive-compulsive disorder (OCD) postulates a hyperactivation of orbitofrontal, limbic, and basal ganglia circuits. We report a case of OCD secondary to brain dysgerminoma affecting this circuit in an adolescent who responded to citalopram. The patient is...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/104454602760386950

    authors: Gamazo-Garrán P,Soutullo CA,Ortuño F

    更新日期:2002-10-01 00:00:00

  • Comparison of Depression and Burnout Levels of Mothers of Children with Attention-Deficit Hyperactivity Disorder Before and After Treatment.

    abstract:OBJECTIVE:This study aimed to compare the depression and burnout levels of mothers of children having attention-deficit/hyperactivity disorder (ADHD) between the child's pre- and posttreatment periods. METHOD:The study sample consisted of 40 children aged between 4 and 10 years and their mothers. Initially, 40 cases p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2017.0050

    authors: Gokcen C,Coskun S,Kutuk MO

    更新日期:2018-06-01 00:00:00

  • Effect of Aptensio XR (Methylphenidate HCl Extended-Release) Capsules on Sleep in Children with Attention-Deficit/Hyperactivity Disorder.

    abstract:OBJECTIVE:To evaluate measures of sleep (exploratory endpoints) in two pivotal studies of a multilayer bead extended-release methylphenidate (MPH-MLR) treatment of attention-deficit/hyperactivity disorder in children. METHODS:Study 1 evaluated the time course of response to MPH-MLR (n = 26) patients in an analog class...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2016.0083

    authors: Owens J,Weiss M,Nordbrock E,Mattingly G,Wigal S,Greenhill LL,Chang WW,Childress A,Kupper RJ,Adjei A

    更新日期:2016-12-01 00:00:00

  • Increased plasma valproate concentrations when coadministered with guanfacine.

    abstract::A preliminary clinical observation suggests the possibility of changes in valproate level when coadministered with guanfacine. Two pediatric inpatients (8 and 9 years of age) were treated with valproic acid and guanfacine concurrently. In one child, when guanfacine was tapered and discontinued, the plasma valproate co...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.1998.8.143

    authors: Ambrosini PJ,Sheikh RM

    更新日期:1998-01-01 00:00:00

  • Effects of serotonin reuptake inhibitors on aggressive behavior in psychiatrically hospitalized adolescents: results of an open trial.

    abstract::Low concentrations of the neurotransmitter serotonin and its 5-hydroxyindoleacetic acid metabolite in the central nervous system have been associated with increased aggressive behavior in animals and humans. Controlled clinical trials of serotonin agonists in depressed adults have suggested that aggressive behavior is...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.1997.7.31

    authors: Constantino JN,Liberman M,Kincaid M

    更新日期:1997-04-01 00:00:00