当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system.

Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system.

Abstract：

:Gene therapy and virotherapy are among the approaches currently being used to treat lung cancer. The success of cancer gene therapy depends on treatments where different types of tumors can be selectively targeted and destroyed without affecting normal cells and tissue. Previously, we described a promoter system (TTS) that we designed that is specifically targeted to lung cancer cells but which does not affect other types of cells including stem cells. In our study, we have enhanced the utility of the TTS system by inserting the pro-apoptotic gene BH3 domain interacting death agonist (Bid) into the TTS promoter system (TTS/Bid) to create a drug regulatable lung cancer-specific gene therapy. A recombinant adenoviral vector was used to introduce TTS/Bid (Ad-TTS/Bid) into lung cancer cells. BID expression and apoptosis occurred in A549 pulmonary adenocarcinoma cells but little Bid expression or apoptosis occurred in MCF7 breast cancer cells or in normal human lung fibroblasts. The use of cisplatin enhanced the processing of full length BID to t-BID which significantly increased lung cancer-specific cell death. In in vivo experiments, intraperitonal injection of cisplatin enhanced the antitumor effects of the vector in a lung cancer xeno-graft mouse model. Moreover, dexamethasone effectively suppressed exogenous BID expression and the antitumor effect of Ad-TTS/Bid both in vitro and in vivo. Here, we describe the efficacy of the use of cisplatin and dexamethasone with the anti lung cancer promoter system (Ad-TTS/Bid) for a safe and effective gene therapy against advanced lung cancer.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Fukazawa T,Maeda Y,Matsuoka J,Tanaka N,Tanaka H,Durbin ML,Naomoto Y

doi

10.1002/ijc.24584

subject

Has Abstract

pub_date

2009-10-15 00:00:00

pages

1975-84

issue

8

eissn

0020-7136

issn

1097-0215

journal_volume

125

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

    abstract：:Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29583

    authors： Schneider V,Zhang L,Rojewski M,Fekete N,Schrezenmeier H,Erle A,Bullinger L,Hofmann S,Götz M,Döhner K,Ihme S,Döhner H,Buske C,Feuring-Buske M,Greiner J

    更新日期：2015-11-01 00:00:00

  • Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells.

    abstract：:Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc

    authors： Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

    更新日期：1997-12-10 00:00:00

  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons.

    abstract：:Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24320

    authors： Mirabello L,Troisi RJ,Savage SA

    更新日期：2009-07-01 00:00:00

  • Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome.

    abstract：:CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28727

    authors： Lim AM,Do H,Young RJ,Wong SQ,Angel C,Collins M,Takano EA,Corry J,Wiesenfeld D,Kleid S,Sigston E,Lyons B,Fox SB,Rischin D,Dobrovic A,Solomon B

    更新日期：2014-08-15 00:00:00

  • Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

    abstract：:Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29434

    authors： Gong Z,Yao S,Zirpoli G,David Cheng TY,Roberts M,Khoury T,Ciupak G,Davis W,Pawlish K,Jandorf L,Bovbjerg DH,Bandera EV,Ambrosone CB

    更新日期：2015-08-01 00:00:00

  • Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.

    abstract：:The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28512

    authors： Zhang C,Sturgis EM,Zheng H,Song X,Wei P,Jin L,Chao L,Wei Q,Li G

    更新日期：2014-04-15 00:00:00

  • Basement membrane proteins promote progression of intraepithelial neoplasia in 3-dimensional models of human stratified epithelium.

    abstract：:We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.11525

    authors： Andriani F,Garfield J,Fusenig NE,Garlick JA

    更新日期：2004-01-20 00:00:00

  • Prognostic significance of TP53 accumulation in human primary breast cancer: comparison between a rapid quantitative immunoassay and SSCP analysis.

    abstract：:TP53 accumulation in human primary breast carcinomas was studied by a quantitative luminometric immunoassay (LIA), and TP53 gene alterations, exons 5-8, were examined by single-strand conformation polymorphism (SSCP) analysis. In 48 of 142 breast tumor samples, a TP53 gene alteration was identified. In tumor samples w...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960422)69:2<125::AID-IJC

    authors： de Witte HH,Foekens JA,Lennerstrand J,Smid M,Look MP,Klijn JG,Benraad TJ,Berns EM

    更新日期：1996-04-22 00:00:00

  • The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.

    abstract：:Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silic...

    journal_title：International journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1002/ijc.27967

    authors： Lantieri F,Caroli F,Ceccherini I,Griseri P

    更新日期：2013-06-15 00:00:00

  • Pharmacokinetics of methotrexate and its 7-OH metabolite in cancer patients treated with different high-methotrexate dosage regimens.

    abstract：:The pharmacokinetics of methotrexate (MX) and 7-OH methotrexate (MXOH) was studied in 18 cancer patients treated with 6-hr intravenous (i.v.) infusion of 100 mg/kg (A), 80 mg/kg preceded by 20 mg/kg i.v. loading dose (B), and 70 mg/kg preceded by 30 mg/kg i.v. loading dose (C). Simultaneous analysis of MX and MXOH was...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910380603

    authors： el-Yazigi A,Amer M,Al-Saleh I,Martin C

    更新日期：1986-12-15 00:00:00

  • Dietary patterns and risk of prostate cancer in Ontario, Canada.

    abstract：:Dietary patterns reflect combinations of dietary exposures, and here we examine these in relation to prostate cancer risk. In a case-control study, 80 incident primary prostate cancer cases and 334 urology clinic controls were enrolled from 1997 through 1999 in Kingston, Ontario, Canada. Food-frequency questionnaires ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21112

    authors： Walker M,Aronson KJ,King W,Wilson JW,Fan W,Heaton JP,MacNeily A,Nickel JC,Morales A

    更新日期：2005-09-10 00:00:00

  • The advantage of residualizing radiolabels for targeting B-cell lymphomas with a radiolabeled anti-CD22 monoclonal antibody.

    abstract：:CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970502)71:3<429::aid-ijc

    authors： Mattes MJ,Shih LB,Govindan SV,Sharkey RM,Ong GL,Xuan H,Goldenberg DM

    更新日期：1997-05-02 00:00:00

  • Differences in antitumor effects of various statins on human pancreatic cancer.

    abstract：:Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23242

    authors： Gbelcová H,Lenícek M,Zelenka J,Knejzlík Z,Dvoráková G,Zadinová M,Poucková P,Kudla M,Balaz P,Ruml T,Vítek L

    更新日期：2008-03-15 00:00:00

  • The mechanism of hepatic uptake of a radiolabelled monoclonal antibody.

    abstract：:Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910500616

    authors： Boyle CC,Paine AJ,Mather SJ

    更新日期：1992-04-01 00:00:00

  • Characterization and partial purification of human milk fat globule membrane antigens by polyacrylamide gel electrophoresis and immunoblotting using monoclonal antibodies.

    abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910350207

    authors： Ashorn P,Krohn K

    更新日期：1985-02-15 00:00:00

  • PITX2: a promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma.

    abstract：:The paired-like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β-catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esopha...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.27930

    authors： Zhang JX,Tong ZT,Yang L,Wang F,Chai HP,Zhang F,Xie MR,Zhang AL,Wu LM,Hong H,Yin L,Wang H,Wang HY,Zhao Y

    更新日期：2013-06-01 00:00:00

  • Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.

    abstract：:Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1401

    authors： Fenton BM,Lord EM,Paoni SF

    更新日期：2001-09-01 00:00:00

  • Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation.

    abstract：:Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990505)81:3<443::aid-ijc

    authors： Xing RH,Rabbani SA

    更新日期：1999-05-05 00:00:00

  • A bacterial genotoxin causes virus reactivation and genomic instability in Epstein-Barr virus infected epithelial cells pointing to a role of co-infection in viral oncogenesis.

    abstract：:We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31652

    authors： Frisan T,Nagy N,Chioureas D,Terol M,Grasso F,Masucci MG

    更新日期：2019-01-01 00:00:00

  • A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling.

    abstract：:Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32728

    authors： Hwang JH,Yoon J,Cho YH,Cha PH,Park JC,Choi KY

    更新日期：2020-05-15 00:00:00

  • Hormone replacement therapy and oral contraceptives and risk of oesophageal adenocarcinoma: a systematic review and meta-analysis.

    abstract：:There is an unexplained strong male predominance in the aetiology of oesophageal adenocarcinoma (OAC). The hypothesis that oestrogens are protective, deserves attention. A potential protective influence of exogenous oestrogen exposure, that is, hormone replacement therapy (HRT) and oral contraceptives (OC) has been ad...

    journal_title：International journal of cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1002/ijc.28869

    authors： Lagergren K,Lagergren J,Brusselaers N

    更新日期：2014-11-01 00:00:00

  • Accuracy of human papillomavirus testing in primary screening of cervical neoplasia: results from a multicenter study in India.

    abstract：:The knowledge that cervical neoplasia are caused by human papillomavirus (HPV) infection has led to the evaluation of its role in screening. We evaluated the accuracy of HPV testing by Hybrid capture II (HC II) method in detecting cervical intraepithelial neoplasia grade 2 and 3 (CIN 2 and 3) lesions in 4 cross-sectio...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.20396

    authors： Sankaranarayanan R,Chatterji R,Shastri SS,Wesley RS,Basu P,Mahe C,Muwonge R,Seigneurin D,Somanathan T,Roy C,Kelkar R,Chinoy R,Dinshaw K,Mandal R,Amin G,Goswami S,Pal S,Patil S,Dhakad N,Frappart L,Fontaniere B

    更新日期：2004-11-01 00:00:00

  • Characterization and outcome of breast needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening.

    abstract：:In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25801

    authors： Rakha EA,Lee AH,Jenkins JA,Murphy AE,Hamilton LJ,Ellis IO

    更新日期：2011-09-15 00:00:00

  • Recombinant IL-2-activated NK cells mediate LAK activity against ovarian cancer.

    abstract：:We investigated the ability of endogenous and recombinant interleukin-2 (IL-2)-stimulated NK cells from normal donors and ovarian cancer patients to mediate lysis of ovarian tumors, and found that peripheral blood (PB) mononuclear cells of normal donors or cancer patients did not display tumoricidal activity against o...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910420214

    authors： Lotzová E,Savary CA,Freedman RS,Edwards CL,Wharton JT

    更新日期：1988-08-15 00:00:00

  • In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

    abstract：:We present an investigation of tumor pH regulation, designed to support a new anticancer therapy concept that we had previously proposed. Our study uses a tumor model of ras-transformed hamster fibroblasts, CCL39, xenografted in the thighs of nude mice. We demonstrate, for the first time, that genetic modifications of...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.26125

    authors： Chiche J,Le Fur Y,Vilmen C,Frassineti F,Daniel L,Halestrap AP,Cozzone PJ,Pouysségur J,Lutz NW

    更新日期：2012-04-01 00:00:00

  • The spectrum of malignancies in HIV-infected patients in 2006 in France: the ONCOVIH study.

    abstract：:Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25903

    authors： Lanoy E,Spano JP,Bonnet F,Guiguet M,Boué F,Cadranel J,Carcelain G,Couderc LJ,Frange P,Girard PM,Oksenhendler E,Poizot-Martin I,Semaille C,Agut H,Katlama C,Costagliola D,ONCOVIH study group.

    更新日期：2011-07-15 00:00:00

  • Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract.

    abstract：:The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910430305

    authors： Malden LT,Novak U,Burgess AW

    更新日期：1989-03-15 00:00:00

  • Rab11-FIP2 promotes the metastasis of gastric cancer cells.

    abstract：:Rab11-FIP2 can interact with MYO5B and plays an important role in regulating plasma membrane recycling. Our previous study has shown that MYO5B is epigenetically silenced and associated with c-Met signaling in human gastric cancer. However, little is known of the function of Rab11-FIP2 in gastric cancer. In this study...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29899

    authors： Dong W,Qin G,Shen R

    更新日期：2016-04-01 00:00:00

  • Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma.

    abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(20000401)86:1<89::aid-ijc1

    authors： Steitz J,Brück J,Steinbrink K,Enk A,Knop J,Tüting T

    更新日期：2000-04-01 00:00:00

  • Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours.

    abstract：:Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910360602

    authors： Kovacs G

    更新日期：1985-12-15 00:00:00