Abstract：
BACKGROUND:Acute rejection is one of the most important factors for prognosis following liver transplantation. With the use of potent immunosuppressants, acute rejection does not always present typical manifestations. Moreover, other complications often occur concomitantly after liver transplantation, which makes early diagnosis of acute rejection more difficult. Acute rejection is best diagnosed by liver biopsy. Differentiation of clinical manifestations and pathological features plays an important role in achieving individualized immunosuppressive treatment and prolonging long term survival of patients given orthotopic liver transplants. METHODS:From January 2004 to December 2006, 516 orthotopic liver transplantations were performed at the First Affiliated Hospital, Sun Yat-sen University. For patients who suffered acute rejection, clinical manifestations, histopathological features, diagnosis and anti-rejection treatment were summarized and analyzed. RESULTS:In 86 cases (16.7%), of the 516 recipients, 106 episodes of acute rejection occurred, which included 9 with histopathological borderline changes, 36 Banff I rejections, 48 Banff II and 13 Banff III. Among these, 36 were cured by adjusting the dose of immunosuppressant and 65 were reversed by methylprednisolone pulse treatment. Five were methylprednisolone resistant, 3 of whom were given OKT3 treatment and 2 underwent liver retransplantation. CONCLUSIONS:Due to potent immunosuppressive agents, acute rejection following an orthotopic liver transplantation lacks typical clinical manifestations and pathological features. Acute rejection is best diagnosed by liver biopsy. Designing rational individualized immunosuppressive regimen based on clinical and pathological features of acute rejection plays an important role in prolonging long term survival of patients.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Ma Y,Wang GD,He XS,Li JL,Zhu XF,Hu RDsubject
Has Abstractpub_date
2009-06-20 00:00:00pages
1400-3issue
12eissn
0366-6999issn
2542-5641journal_volume
122pub_type
杂志文章abstract：OBJECTIVE:To review the research progress on Type IV secretion system (T4SS) in Helicobacter pylori. DATA SOURCES:The data used in this review were identified by searching of PUBMED (1995 - 2007) online resources using the key terms 'Type IV secretion system' and 'Helicobacter pylori'. STUDY SELECTION:Mainly original...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2007-12-05 00:00:00
abstract：BACKGROUND:A satisfactory animal model of breast cancer metastasizing to bone is unavailable. In this study, we used human breast cancer stem-like cells and human bone to build a novel "human-source" model of human breast cancer skeletal metastasis. METHODS:Human breast cancer stem-like cells, the CD44+/CD24-/lower su...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-10-20 00:00:00
abstract：BACKGROUND:To date, there have been no reports on altered nitric oxide (NO) content in ischemia/reperfusion with regard to in vivo preconditioning procedures. These studies are important for understanding the mechanisms of NO during early myocardial ischemic preconditioning. The aim of the present study was to investig...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-07-05 00:00:00
abstract：:Thallium-201 dipyridamole test (Tl-201DT) has high sensitivity and specificity in the assessment of coronary disease (CAD), but is not always available. We proposed impedance cardiography DT (IDT)instead. To determine the characteristic changes of impedance cardiogram (ICG) in patients with typical angina and to compa...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND:Despite the prevalence of Streptococcus pneumoniae serotype 19A, the molecular characteristics of this serotype are yet to be fully elucidated. The aim of this study was therefore to determine the homology of the serotype 19A in China. METHODS:Pulsed-field gel electrophoresis and multilocus sequence typing ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To investigate the use of the Gibbs-Sampler method in evaluating the relationship between clinic events and health risks in a meta-analysis of multiple clinical trials. METHODS:By using a generalized linear model with random-effects, Gibbs-Sampler technique was used in a meta-analysis of multiple clinical tr...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The activation of extracellular signal-regulated kinase1/2 (ERK1/2) has been shown to be important signaling pathway in the ischemic preconditioning (IPC) response. Recently, some studies suggest a key role for the mitochondrial ATP-sensitive potassium channel (mKATP) as both a trigger and an end effector of...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Survivin is an oncoprotein silenced in normal mature tissues but reactivated in serous ovarian cancer (SOC). Although transcriptional activation is assumed for its overexpression, the long 3'-untranslated region (3'-UTR) in survivin gene, which contains many alternate polyadenylation (APA) sites, implies a p...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.181965
更新日期：2016-05-20 00:00:00
abstract：OBJECTIVE:To describe the clinical features, operative methods and postoperative management of the intra-axial tumors of medullocervical junction, and to make differential diagnosis for different subtypes. METHODS:Fifteen patients with intra-axial tumors of medullocervical junction were treated from August 1988 to Jun...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:O(6)-methylguanine-DNA-methyltransferase (MGMT) is a specific DNA revising enzyme transferring alkylated groups from DNA to its cysteine residue to avoid the abnormal twisting of DNA. Therefore, it is one of the drug resistant genes targeted in the treatment of cancer. This study explored the protective effe...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2007-04-20 00:00:00
abstract：BACKGROUND:Alzheimer disease (AD) is a neurodegenerative disease related to aging. At present, its pathological mechanisms remain unclear. Family members of the renin-angiotensin system (RAS) play a role in neuronal plasticity, as well as formation of learning and memory. In this study, we explore the effects of altere...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-11-20 00:00:00
abstract：BACKGROUND:Methylmalonic acidemia (MMA) is a multifactorial autosomal recessive inborn error of organic acid metabolism, often presenting with neurological symptoms. As neurological disorders are often related to white matter injury, diffusion tensor imaging (DTI) is an excellent tool for assessment of white matter inj...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-04-20 00:00:00
abstract：BACKGROUND:Using tissue Doppler imaging and conventional echocardiographic technique, we examined the cardiac function and synchronicity in individuals with isolated right bundle branch block (RBBB) or left bundle branch block (LBBB) and assessed the relationship between QRS duration and synchronicity. METHODS:Subject...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2006-05-20 00:00:00
abstract：BACKGROUND:Transgenic overexpression of human prostasin in rats disturbs salt balance and causes hypertension. We investigated whether genetic variations in prostasin were implicated in hypertension or related phenotypes in the Xinjiang Kazakh population. METHODS:We sequenced all exons and the promoter regions of the ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Successful antiretroviral therapy (ART) has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus (HIV). We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model (AEM). METHOD...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.196571
更新日期：2017-01-01 00:00:00
abstract：: ...
journal_title：Chinese medical journal
pub_type： 信件
doi：10.4103/0366-6999.243565
更新日期：2018-10-20 00:00:00
abstract：BACKGROUND:Congenital heart disease (CHD) is a common heart condition which does considerable harm to the health of children and adolescents. CHD epidemiological characteristics of Tibetan children whose ages ranged from 4 to 18 years were investigated in Qinghai Province. METHODS:A total of 32 578 Tibetan children, l...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-12-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-04-05 00:00:00
abstract：BACKGROUND:Endovenous laser ablation (EVLA) is an improved method to treat varicose great saphenous veins (GSV) with a high satisfactory rate. This study aimed to evaluate the efficiency and safety of treatment by EVLA procedures with ultrasound-guided perivenous tumescence. METHODS:Thirty-one patients (31 limbs) with...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases. METHODS:Collecting clinical data of three cases of human infection with a novel reas...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aimed to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to f...
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pub_type： 杂志文章
doi：10.1097/CM9.0000000000000775
更新日期：2020-05-05 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-01-20 00:00:00
abstract：:Eight strains of sonicated Helicobacter pylori (H. pylori) were pooled as group antigen to detect the serum IgG antibody to H. pylori in patients with various gastroduodenal diseases and subjects at health check-up. The enzyme-linked immunosorbent assay method used had a sensitivity of 94%, a specificity of 87%, and a...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Drug-eluting stents represent a major advance in interventional cardiology. However, the current drug-eluting stents have significant limitations. One of the major problems is very late stent thrombosis, which is likely caused by inflammation and a hypersensitivity reaction related to a polymer on the stent....
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The dyschromatoses are a group of disorders characterized by simultaneous hyperpigmented macules together with hypopigmented macules. Dyschromatosis universalis hereditaria (DUH) and dyschromatosis symmetrica hereditaria are two major types. While clinical and histological presentations are similar in these ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.172564
更新日期：2016-01-05 00:00:00
abstract：BACKGROUND:Pulmonary endarterectomy is safe and effective surgical treatment for chronic thromboembolic pulmonary hypertension. This study aimed to evaluate the efficacy of pulmonary endarterectomy in treatment of thromboembolic pulmonary hypertension. METHODS:A retrospective study of 15 patients who underwent pulmona...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2010-04-20 00:00:00
