Fractional anisotropy for assessment of white matter tracts injury in methylmalonic acidemia.

Abstract:

BACKGROUND:Methylmalonic acidemia (MMA) is a multifactorial autosomal recessive inborn error of organic acid metabolism, often presenting with neurological symptoms. As neurological disorders are often related to white matter injury, diffusion tensor imaging (DTI) is an excellent tool for assessment of white matter injury and possibly for diagnosing this disorder. METHODS:We retrospectively analyzed DTI images of 12 patients with MMA (7 males, 5 females, age range: 7 - 12 months, mean age: 9.25 +/- 1.70 months) with negative MRI findings. And another 12 age-matched and gender-matched infants were enrolled as control subjects. Fractional anisotropy (FA) of different white matter tracts of the brain was measured in both groups. RESULTS:For patients with negative MRI findings, compared with healthy infants, a statistically significant reduction in DTI FA value of the frontal white matter, temporal white matter, and occipital white matter was observed (P < 0.01). CONCLUSIONS:In addition to conventional T1W and T2W MR Image, Brain DTI presents a useful, sensitive and complementary tool for the assessment of brain damage in patients with MMA.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Gao Y,Guan WY,Wang J,Zhang YZ,Li YH,Han LS

subject

Has Abstract

pub_date

2009-04-20 00:00:00

pages

945-9

issue

8

eissn

0366-6999

issn

2542-5641

journal_volume

122

pub_type

杂志文章
  • Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography.

    abstract:OBJECTIVE:To investigate whether coagulation factor VII (FVII) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial infarction (MI) in a series of Hans. METHODS:The Arg(353)Gln and HVR4 polymorphisms of FVII gene were determined in 374 patients undergoing selective coronary ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu G,Jin G,Fu G,Ma J,Shi Y,Tang O,Shan J

    更新日期:2003-08-01 00:00:00

  • Safety and feasibility of transradial approach for primary percutaneous coronary intervention in elderly patients with acute myocardial infarction.

    abstract:BACKGROUND:Transradial coronary intervention has been widely used because of its effects in lowering the incidence of complications in vascular access site and improving patient satisfaction compared to the femoral approach. This study aimed to investigate the safety and feasibility of transradial approach for primary ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yan ZX,Zhou YJ,Zhao YX,Liu YY,Shi DM,Guo YH,Cheng WJ

    更新日期:2008-05-05 00:00:00

  • Surgical treatment of cervical spine tumors.

    abstract::Of 40 patients with cervical spine tumor treated from 1980 to 1990, 24 had a primary tumor and 16 a metastatic tumor. Thirty-four patients were operated on through anterior and 5 through posterior approach. Preoperative neck pain was relieved and muscular strength of shoulder and arm increased after operation. Total e...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu HK,Liu ZD

    更新日期:1992-07-01 00:00:00

  • Efficacy of hepatitis B immunoglobulin in relation to the gene polymorphisms of human leukocyte Fcgamma receptor III (CD16) in Chinese liver transplant patients.

    abstract:BACKGROUND:Although the use of hepatitis B immunoglobulin (HBIG) may lead to a significant reduction in recurrent hepatitis B virus (HBV) infection and improve the survival of patients who have undergone liver transplantation (LT) for hepatitis B-related diseases, the recurrence of the disease still remains at a lower ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang WL,Zhang GL,Wu LH,Yao MY,Jin J,Jia CK,Xie HY,Zhou L,Jiang ZJ,Zheng SS

    更新日期:2007-09-20 00:00:00

  • Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid.

    abstract:BACKGROUND:CD4(+)CD25(+) regulatory T cells (Tregs) mediate immune suppression through cell-cell contact with surface molecules, particularly cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR), and transforming growth factor beta (TG...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang Q,Qian FH,Liu H,Zhou LF,Huang M,Zhang XL,Yin KS

    更新日期:2008-02-05 00:00:00

  • Anastomotic false aneurysm following abdominal aortic aneurysmectomy and prosthetic grafting.

    abstract::Anastomotic false aneurysm (AFA) of the aorta is a potentially lethal complication after prosthetic grafting. Nineteen aneurysms were encountered in 18 patients within a 30-year period (1960-1991). There were 10 men and 8 women, aged 27-80 years (mean 58 years). In 14 patients, the prostheses were made of silk, in 2 w...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen FZ,Xu X,Fu WG,Wu ZG

    更新日期:1994-11-01 00:00:00

  • Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes.

    abstract:BACKGROUND:Interferon (IFN) can inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro and in clinic. However, IFN therapy for HIV infection was limited by its moderate antiviral efficacy and its frequent adverse effects. In the present study we evaluated the anti-HIV efficacy of a novel synthesized s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang W,Tong X,Nakasone T,Yue XT,Yamamoto N,Liu XY,Yang RG

    更新日期:2011-02-01 00:00:00

  • Antimicrobial resistance and molecular epidemiological characteristics of clinical isolates of Staphylococcus aureus in Changsha area.

    abstract:BACKGROUND:Increasing prevalence of Staphylococcus aureus (S. aureus), particularly methicillin-resistant S. aureus (MRSA) has been reported in China. In this study, we investigated the drug resistance characteristic, genetic background, and molecular epidemiological characteristic of S. aureus in Changsha. METHODS:Be...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zou MX,Zhou RR,Wu WJ,Zhang NJ,Liu WE,Hu FP,Fan XG

    更新日期:2012-07-01 00:00:00

  • Effect of artificial colloids on blood coagulation during shock stage of severe burn injury.

    abstract:BACKGROUND:There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. METHODS:Totally, 18 female Ba-Ma mini-pigs were subjected to a 40% total body surface third-degree flame...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhou JJ,Xing N,Chen J,Shi JW,Su GL

    更新日期:2013-01-01 00:00:00

  • Macroscopic and histological evaluations of meniscal allograft transplantation using gamma irradiated meniscus: a comparative in vivo animal study.

    abstract:BACKGROUND:Many studies suggest that the gamma irradiation decreases allograft strength in a dose-dependent manner. However, no study has demonstrated that this decrease in strength translates into higher failure rate in meniscal allograft transplantation (MAT). The aim of this study was to investigate the effects of g...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.156784

    authors: Zhang J,Song GY,Chen XZ,Li Y,Li X,Zhou JL

    更新日期:2015-05-20 00:00:00

  • Differences of Matrix Metalloproteinase 2 Expression between Left and Right Ventricles in Response to Nandrolone Decanoate and/or Swimming Training in Mice.

    abstract:BACKGROUND:Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND), swimming training (ST), and combined ND and ST (NS) in mice, based on...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.222330

    authors: Bai Y,Shi XB,Zhang YQ,Wang YL,Liu XY,Esteve-Pastor MA

    更新日期:2018-01-20 00:00:00

  • Fungal infection in organ transplant patients.

    abstract:PURPOSE:To review the characteristics and evolution of the fungal spectrum, and the risk factors causing fungal infection, and to make progress in diagnosing fungal infection after organ transplantation. DATA SOURCES:An English-language literature search (MEDLINE 1990 - 2000) and bibliographic review of textbooks and ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Hong W,Wen H,Liao W

    更新日期:2003-09-01 00:00:00

  • Surgery for sinus of Valsalva aneurysm: 33-year of a single center experience.

    abstract:BACKGROUND:Sinus of Valsalva aneurysm (SVA) is a rare anomaly and few large or long-term series are well established. This study was designed to review 33-year surgical experience of SVA in one center. METHODS:From August 1980 to December 2013, patients with SVA underwent surgical repair were retrospectively studied. ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yan F,Abudureheman M,Huo Q,Shabiti A,Zhu T,Liu Z

    更新日期:2014-01-01 00:00:00

  • Quantitative evaluation of acute renal failure in rabbits with contrast-enhanced ultrasound.

    abstract:BACKGROUND:Assessment of perfusion in the early period of acute renal failure (ARF) is important, and can not be made by conventional ultrasound. The aim of this study was to prospectively test in a rabbit ARF model whether real-time contrast-enhanced ultrasound (CEUS) can quantitatively evaluate the hemodynamic change...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Dong Y,Wang WP,Cao JY,Fan PL,Lin XY

    更新日期:2012-02-01 00:00:00

  • Genetic heterogeneity for familial hypertrophic cardiomyopathy in Chinese: analysis of six Chinese kindreds.

    abstract:OBJECTIVE:Familial hypertrophic cardiomyopathy (FHCM) is a primary myocardial disease characterized by unexplained ventricular hypertrophy. The application of the techniques of reverse genetics has identified at least five chromosomal loci as the major causes for FHCM in diverse ethnic populations, suggesting substanti...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ko YL,Teng MS,Tang TK,Chen JJ,Lee YS,Wu CW,Lien WP,Liew CC

    更新日期:1998-05-01 00:00:00

  • Safety and efficacy of a novel technique in the use of fractional flow reserve in complex coronary artery lesions.

    abstract:BACKGROUND:Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis. However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.152664

    authors: He WM,Li CL,Sun Y,Zhou Z,Mai YF

    更新日期:2015-03-20 00:00:00

  • Computed tomographic demonstrations of HIV seropositive pulmonary tuberculosis and their relationship with CD4+ T-lymphocyte count.

    abstract:BACKGROUND:Factors of cell-mediated immunity and allergy together play their roles in the pathogenesis of pulmonary tuberculosis (PTB) and its prognosis. The purpose of this study was to investigate the computed tomographic demonstrations of HIV seropositive PTB and the relationship between its pathogenesis and CD4(+) ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang YZ,Li HJ,Cheng JL,Wu H,Bao DY

    更新日期:2011-03-01 00:00:00

  • Involvement of membrane glycophorins in human erythrocytes invaded by Plasmodium falciparum.

    abstract::The extent of participation and changes of glycophorins (GPs) and membrane proteins in the merozite-human erythrocyte interaction during the invasion of Plasmodium falciparum (Pf) were studied by immunoblotting techniques. Polyclonal antisera to alpha GP and to its C-terminal fragment (residues 82-131) as well as M an...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu JF,Lu YQ,Roth EF Jr,Nagel RL,Blumenfeld OO

    更新日期:1993-04-01 00:00:00

  • A vascular endothelial growth factor activating transcription factor increases the endothelial progenitor cells population and induces therapeutic angiogenesis in a type 1 diabetic mouse with hindlimb ischemia.

    abstract:BACKGROUND:Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue perfusion. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. However, it has side effects that limit its therapeutic utility in vivo, especially at high concentrations. This study aimed ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Diao Y,Lian L,Guo L,Chen H,Chen Y,Song X,Li Y

    更新日期:2014-01-01 00:00:00

  • Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases.

    abstract:OBJECTIVE:To provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease. DATA SOURCES:To identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15. STUDY SELECTION:Well-controlled, relat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Liu HT,Wang HC,Tao L,Li CX,Li F,Zhang YY,Liu BW

    更新日期:2013-04-01 00:00:00

  • Premature atherosclerosis in patients with acquired immunodeficiency syndrome.

    abstract:BACKGROUND:Increased risk of atherosclerosis has been reported in patients with human immunodeficiency virus (HIV) infection since highly active antiretroviral therapy (HAART) has come into use. However, there is no clear evidence of premature atherosclerosis in Chinese HIV-infected patients. Our study was designed to ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zeng Y,Ye YC,Luo L,Qiu ZF,Han Y,Li XM,Fang Q,Zhang SY,Li TS

    更新日期:2010-12-01 00:00:00

  • Establishment of a Rabbit Model of Chronic Obstructive Sleep Apnea and Application in Cardiovascular Consequences.

    abstract:BACKGROUND:Although obstructive sleep apnea (OSA) has been recognized as a major risk factor for cardiovascular complications and its clinical features are well characterized, it is difficult to replicate the OSA hypoxic model in humans. We aimed to establish an experimental rabbit model for chronic OSA and to explore ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.199828

    authors: Xu LF,Zhou XF,Hu K,Tang S,Luo YC,Lu W

    更新日期:2017-02-20 00:00:00

  • Clinical Control Study of Endoscopic Full-thickness Resection and Laparoscopic Surgery in the Treatment of Gastric Tumors Arising from the Muscularis Propria.

    abstract:BACKGROUND:Gastric stromal tumors arising from the muscularis propria are located in deeper layers. Endoscopic resection may be contraindicated due to the possibility of perforation. These tumors are therefore usually removed by surgical or laparoscopic procedures. This study evaluated the curative effects, safety and ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.157651

    authors: Wu CR,Huang LY,Guo J,Zhang B,Cui J,Sun CM,Jiang LX,Wang ZH,Ju AH

    更新日期:2015-06-05 00:00:00

  • Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss.

    abstract:BACKGROUND:The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly understood. This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL. METHODS:One hundred and thir...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.179791

    authors: Li FJ,Wang DY,Wang HY,Wang L,Yang FB,Lan L,Guan J,Yin ZF,Rosenhall U,Yu L,Hellstrom S,Xue XJ,Duan ML,Wang QJ

    更新日期:2016-04-20 00:00:00

  • Efficacy evaluation for the treatment of subcapital femoral neck fracture in young adults by capsulotomy reduction and closed reduction.

    abstract:BACKGROUND:Subcapital femoral neck fracture in young adults has many complications, and the incidence is increasing year-by-year. The selection of the proper operation method to avoid them is an ambiguous matter. This study aimed to evaluate the treatment effect of subcapital femoral neck fracture by the capsulotomy an...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0366-6999.151092

    authors: Liu C,Liu MT,Li P,Xu HH

    更新日期:2015-02-20 00:00:00

  • Neoadjuvant Chemoradiotherapy Improving Survival Outcomes for Esophageal Carcinoma: An Updated Meta-analysis.

    abstract:BACKGROUND:The effectiveness of neoadjuvant chemoradiotherapy (NCRT) treatment for patients with esophageal carcinoma (EC) remains controversial. The aim of this study was to compare the effect of NCRT followed by surgery (NCRTS) with surgery alone (SA) for EC. METHODS:The PubMed, EMBASE, and the Cochrane Library data...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析

    doi:10.4103/0366-6999.195464

    authors: Wang DB,Sun ZY,Deng LM,Zhu DQ,Xia HG,Zhu PZ

    更新日期:2016-12-20 00:00:00

  • Effect of human rhinovirus infection in pediatric patients with influenza-like illness on the 2009 pandemic influenza A(H1N1) virus.

    abstract:BACKGROUND:Some research groups have hypothesized that human rhinoviruses (HRVs) delayed the circulation of the 2009 pandemic influenza A(H1N1) virus (A(H1N1)pdm09) at the beginning of Autumn 2009 in France. This study aimed to evaluate the relationship between HRV and A(H1N1)pdm09 in pediatric patients with influenza-...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Sun Y,Zhu R,Zhao L,Deng J,Wang F,Ding Y,Yuan Y,Qu D,Qian Y

    更新日期:2014-01-01 00:00:00

  • Low molecular weight heparin suppresses lymphatic endothelial cell proliferation induced by vascular endothelial growth factor C in vitro.

    abstract:BACKGROUND:Pancreatic cancer is one of the most aggressive human malignancies. Lymphangiogenesis plays an important role in lymph node metastasis of many solid tumors. It is well known that low molecular weight heparins (LMWHs) can inhibit cell growth, cell invasion and angiogenesis, which are key processes in tumor pr...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Cao G,Wu JX,Wu QH

    更新日期:2009-07-05 00:00:00

  • Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.

    abstract:BACKGROUND:Studies have shown that β-blockers can improve cardiac performance in heart failure (HF) by reversing protein kinase A (PKA)-mediated sarcoplasmic reticulum (SR) Ca2+ leak. However, it is being strongly questioned as to whether the PKA-mediated ryanodine receptor (RyR2) hyper-phosphorylation is a critical re...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang SJ,Liu ZH,Zou C,Wang L

    更新日期:2012-03-01 00:00:00

  • Enteric transmission of transfusion-transmitted virus.

    abstract:OBJECTIVE:To detect the virus in the feces and sera of patients in an outbreak of enterically transmitted non-A, non-E hepatitis, and this review covers the epidemiologic features and experimental infection of this novel virus. DATA SOURCES:Data sources come from our own work on this subject, published and unpublished...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Luo K,Zhang L

    更新日期:2001-11-01 00:00:00