Transcriptional profiling identifies the metabolic phenotype of gonococcal biofilms.

abstract：:The selC tRNA gene is a common site for the insertion of pathogenicity islands in a variety of bacterial enteric pathogens. We demonstrate here that Escherichia coli that produces Shiga toxin 2d and does not harbor the locus of enterocyte effacement (LEE) contains, instead, a novel genomic island. In one representativ...

journal_title：Infection and immunity

authors： Schmidt H,Zhang WL,Hemmrich U,Jelacic S,Brunder W,Tarr PI,Dobrindt U,Hacker J,Karch H

更新日期：2001-11-01 00:00:00

abstract：:The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...

journal_title：Infection and immunity

authors： Roxas JL,Koutsouris A,Viswanathan VK

更新日期：2007-05-01 00:00:00

abstract：:Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...

journal_title：Infection and immunity

authors： Elsner A,Kreikemeyer B,Braun-Kiewnick A,Spellerberg B,Buttaro BA,Podbielski A

更新日期：2002-09-01 00:00:00

abstract：:In order to evaluate during experimental Trypanosoma brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha-/-) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites. I...

journal_title：Infection and immunity

authors： Magez S,Radwanska M,Beschin A,Sekikawa K,De Baetselier P

更新日期：1999-06-01 00:00:00

abstract：:Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here, we used Drosophila melanogaster, in conjunctio...

journal_title：Infection and immunity

authors： Bastos RG,Howard ZP,Hiroyasu A,Goodman AG

更新日期：2017-06-20 00:00:00

abstract：:Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...

journal_title：Infection and immunity

authors： Moschioni M,Emolo C,Biagini M,Maccari S,Pansegrau W,Donati C,Hilleringmann M,Ferlenghi I,Ruggiero P,Sinisi A,Pizza M,Norais N,Barocchi MA,Masignani V

更新日期：2010-12-01 00:00:00

abstract：:A battery of lymphoid and nonlymphoid cells was examined for susceptibility to lysis by natural killer cells of chickens. Several susceptible targets were recognized, and most susceptible among these were cells of line LSCC-RP9, derived from a lymphoid tumor induced by Rous-associated virus 2. The natural killer react...

journal_title：Infection and immunity

authors： Sharma JM,Okazaki W

更新日期：1981-03-01 00:00:00

abstract：:Infection of L cells with Chlamydia psittaci inhibited the burst of deoxyribonucleic acid synthesis that occurs when the host cells are released from a double thymidine block. ...

journal_title：Infection and immunity

authors： Tribby II,Moulder JW

更新日期：1971-02-01 00:00:00

abstract：:Genetic resistance to lethal infection with Rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Gilliam strain of R. tsutsugamushi showed three patterns of response: susceptible (A/HeJ, C3H/HeDub, C3H/HeJ, C3H/HeN, ...

journal_title：Infection and immunity

authors： Groves MG,Osterman JV

更新日期：1978-02-01 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00

abstract：:Cell-free hemoglobin (Hb) is being developed as an erythrocyte substitute. We have previously demonstrated that cell-free Hb is an endotoxin-binding protein which disaggregates endotoxin and subsequently increases the biological activity of endotoxin in several in vitro assays. Because much of the morbidity and mortal...

journal_title：Infection and immunity

authors： Su D,Roth RI,Yoshida M,Levin J

更新日期：1997-04-01 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes replicates mainly in resting macrophages and hepatocytes residing in infected tissues. Both innate and acquired resistance strongly depend on activation of listericidal capacities of macrophages by gamma interferon (IFN-gamma) produced by natural killer cells and T lym...

journal_title：Infection and immunity

authors： Szalay G,Hess J,Kaufmann SH

更新日期：1995-08-01 00:00:00

abstract：:Lower genital tract infection with Chlamydia trachomatis and C. muridarum can induce long-lasting hydrosalpinx in the upper genital tract of women and female mice, respectively. However, A/J mice were highly resistant to induction of long-lasting hydrosalpinx by C. muridarum. We further compared host inflammatory resp...

journal_title：Infection and immunity

authors： Zhang H,Zhou Z,Chen J,Wu G,Yang Z,Zhou Z,Baseman J,Zhang J,Reddick RL,Zhong G

更新日期：2014-07-01 00:00:00

abstract：:We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor [CPAF]). We now report that sera collected from these infected individuals neutralized the proteolytic act...

journal_title：Infection and immunity

authors： Sharma J,Dong F,Pirbhai M,Zhong G

更新日期：2005-07-01 00:00:00

abstract：:The antigenically conserved proteins of Treponema pallidum subsp. pallidum and four nonpathogenic cultivatable treponemes were investigated by phase partitioning with the nonionic detergent Triton X-114 and immunoblot analysis. None of the T. pallidum integral membrane proteins identified by phase partitioning (deterg...

journal_title：Infection and immunity

authors： Radolf JD,Norgard MV

更新日期：1988-07-01 00:00:00

abstract：:A Clostridium difficile isolate was found to produce an actin-specific ADP-ribosyltransferase (CDT) homologous to the enzymatic components of Clostridium perfringens iota toxin and Clostridium spiroforme toxin (M. R. Popoff, E. J. Rubin, D. M. Gill, and P. Boquet, Infect. Immun. 56:2299-2306, 1988). The CDT locus from...

journal_title：Infection and immunity

authors： Perelle S,Gibert M,Bourlioux P,Corthier G,Popoff MR

更新日期：1997-04-01 00:00:00

abstract：:Secreted and surface-exposed antigens of intracellular pathogens are thought to provide target structures for detection by the host immune system. The major secreted product of intracellular Leishmania mexicana amastigotes, a proteophosphoglycan (aPPG), is known to contribute to the establishment of the parasitophorou...

journal_title：Infection and immunity

authors： Aebischer T,Harbecke D,Ilg T

更新日期：1999-10-01 00:00:00

abstract：:The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

journal_title：Infection and immunity

authors： Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

更新日期：2006-10-01 00:00:00

abstract：:Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...

journal_title：Infection and immunity

authors： Casselli T,Lynch T,Southward CM,Jones BW,DeVinney R

更新日期：2008-05-01 00:00:00

abstract：:We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or co...

journal_title：Infection and immunity

authors： Bean AG,Freiberg RA,Andrade S,Menon S,Zlotnik A

更新日期：1993-11-01 00:00:00

abstract：:Endotoxin may cause abnormal deposition of platelet-endotoxin aggregates, and this event could have damaging effects. We compared the aggregation characteristics of platelets from rabbits made tolerant to the lethal effects of endotoxin with those of platelets from normal rabbits. Platelets from tolerant rabbits aggre...

journal_title：Infection and immunity

authors： Walker RI,Shields LJ,Fletcher JR

更新日期：1978-03-01 00:00:00

abstract：:The nonacylated form of protein D (PDm) of Haemophilus influenzae has been shown to induce the production of antibodies that are bactericidal to homologous and heterologous nontypeable H. influenzae (NTHi) strains. In this study, immunization of rats with lipoprotein D (LPD) induced higher levels of anti-protein D imm...

journal_title：Infection and immunity

authors： Akkoyunlu M,Melhus A,Capiau C,van Opstal O,Forsgren A

更新日期：1997-12-01 00:00:00

abstract：:The ability of oral immunization to interfere with the establishment of infection with Helicobacter felis was examined. Groups of Swiss Webster mice were immunized orally with 250 micrograms of Helicobacter pylori recombinant urease (rUrease) and 10 micrograms of cholera toxin (CT) adjuvant, 1 mg of H. felis sonicate ...

journal_title：Infection and immunity

authors： Pappo J,Thomas WD Jr,Kabok Z,Taylor NS,Murphy JC,Fox JG

更新日期：1995-04-01 00:00:00

abstract：:Cell wall proteins with sialidase activity are involved in carbohydrate assimilation, adhesion to mucosal surfaces, and biofilm formation. Gardnerella spp. inhabit the human vaginal microbiome and encode up to three sialidase enzymes, two of which are suspected to be cell wall associated. Here we demonstrate that the ...

journal_title：Infection and immunity

authors： Kurukulasuriya SP,Patterson MH,Hill JE

更新日期：2020-12-23 00:00:00

abstract：:We previously showed that the Uganda Palo Alto line of Plasmodium falciparum propagated in Saimiri monkeys and the line maintained in culture in human erythrocytes for many years in our laboratory are genetically unrelated (T. Fandeur, S. Bonnefoy, and O. Mercereau-Puijalon, Mol. Biochem. Parasitol. 47:167, 1991). Whe...

journal_title：Infection and immunity

authors： Fandeur T,Gysin J,Mercereau-Puijalon O

更新日期：1992-04-01 00:00:00

abstract：:The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to k...

journal_title：Infection and immunity

authors： Paton JC,Ferrante A

更新日期：1983-09-01 00:00:00

abstract：:The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pai...

journal_title：Infection and immunity

authors： Uplekar S,Heym B,Friocourt V,Rougemont J,Cole ST

更新日期：2011-10-01 00:00:00

abstract：:Immunoglobulin class-specific antibodies were measured by a solid-phase radioimmunoassay in serum, bronchoalveolar washings (BAW), lung cell lysates, and spleen cell lysates in germfree mice after intranasal (i.n.) and intraperitoneal (i.p.) primary and secondary 10(5), 10(4), and 10(3) mean tissue culture infective d...

journal_title：Infection and immunity

authors： Charlton D,Blandford G

更新日期：1977-09-01 00:00:00

abstract：:The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with M...

journal_title：Infection and immunity

authors： Witter RL,Lee LF,Bacon LD,Smith EJ

更新日期：1979-10-01 00:00:00

abstract：:Mucosa-associated invariant T (MAIT) cells are an innate-like T cell subset in mammals that recognize microbial vitamin B metabolites presented by the evolutionarily conserved major histocompatibility complex class I (MHC I)-related molecule, MR1. Emerging data suggest that MAIT cells may be an attractive target for v...

journal_title：Infection and immunity

authors： Vorkas CK,Levy O,Skular M,Li K,Aubé J,Glickman MS

更新日期：2020-12-15 00:00:00