Effects of altering the germination potential of Bacillus anthracis spores by exogenous means in a mouse model.

Abstract:

:Inhalational anthrax is the most severe form of anthrax. It has been shown in small-animal and non-human primate models that relatively large pools of ungerminated Bacillus anthracis spores can remain within the alveolar spaces for days to weeks post-inhalation or until transported to areas more favourable for germination and bacillary outgrowth. In this study, spores of the Ames strain that were exposed to germination-inducing media prior to intranasal delivery were significantly less infectious than spores delivered in either water or germination-inhibitory medium. The effect of manipulating the germination potential of these spores within the lungs of infected mice by exogenous germination-altering media was examined. The data suggested that neither inducing germination nor inhibiting germination of spores within the lungs protected mice from the ensuing infection. Germination-altering strategies could, instead, significantly increase the severity of disease in a mouse model of inhalational anthrax when implemented in vivo. It was shown that germination-altering strategies, in this study, were not beneficial to the infected host and are impractical as in vivo countermeasures.

journal_name

J Med Microbiol

authors

Cote CK,Bozue J,Twenhafel N,Welkos SL

doi

10.1099/jmm.0.008656-0

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

816-825

issue

Pt 6

eissn

0022-2615

issn

1473-5644

journal_volume

58

pub_type

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