Abstract：
:Coccidioidal pericarditis is a condition found in approximately 1-5% of patients infected by Coccidioides species. It is associated with widely diverse clinical symptoms. This paper reports a case of coccidioidal pericarditis diagnosed by an in-house Coccidioides posadasii antigen and confirmed with mycological and molecular methods. From February to September 2005, the patient suffered from fever, weight loss, a non-productive cough, thoracic pain and tachycardia. He received a positive diagnosis of coccidioidal pericarditis only in October 2005. The macromorphological examination of the culture showed a whitish felt-like colony, which became brownish with age. Preparations in lactophenol cotton blue stain showed hyaline septate hyphae with fragmentation and thin arthroconidia-like structures. Pericardial fluid and sera samples were positive for Coccidioides antibodies by immunodiffusion and ELISA with a C. posadasii in-house antigen preparation. The C. posadasii identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Brilhante RSN,Cordeiro RA,Rocha MFG,Fechine MAB,Furtado FM,Nagao-Dias AT,Camargo ZP,Sidrim JJCdoi
10.1099/jmm.0.2008/002428-0subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1288-1292issue
Pt 10eissn
0022-2615issn
1473-5644journal_volume
57pub_type
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