The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion.

abstract：:Chick embryo fibroblasts cultivated in vitro and Ehrlich ascites tumor cells (in vivo or in vitro) have been treated with amphotericin B. Cell multiplication is strongly inhibited. Large clear zones appear in the fibroblast nucleoi (phase-contrast and electron-microscope observations). Many treated fibroblasts and tum...

journal_title：Journal of cell science

authors： De Paermentier F,Bassleer R,Lepoint A,Desaive C,Goessens G,Lhoest-Gauthier MP

更新日期：1975-08-01 00:00:00

abstract：:In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several...

journal_title：Journal of cell science

authors： O'Keefe S,Roboti P,Duah KB,Zong G,Schneider H,Shi WQ,High S

更新日期：2021-01-19 00:00:00

abstract：:Expression of the vitronectin gene was detected in advanced human astrocytoma by in situ hybridization, whereas vitronectin mRNA was undetectable in low grade tumors or in normal adult brain, indicating that vitronectin is a marker of malignant astrocytoma. We established a model of human astrocytoma by transplanting ...

journal_title：Journal of cell science

authors： Gladson CL,Wilcox JN,Sanders L,Gillespie GY,Cheresh DA

更新日期：1995-03-01 00:00:00

abstract：:The apical region of the Drosophila testis contains a niche with two stem cell populations: germline stem cells (GSCs) and cyst progenitor cells (CPCs). Asymmetrical division of these stem cells leads to gonioblast daughters (which undergo further mitoses) and cyst cell daughters (which withdraw from the cell cycle an...

journal_title：Journal of cell science

authors： Riparbelli MG,Colozza G,Callaini G

更新日期：2009-10-15 00:00:00

abstract：:The role of inhibition of prelamin A processing in the inhibition of DNA synthesis by lovastatin was examined by expressing prelamin A in F9 teratocarcinoma cells. These cells, normally lacking expression of the A/C lamins, were transfected with constructs expressing either prelamin A or mature lamin A and the effect ...

journal_title：Journal of cell science

authors： Sinensky M,McLain T,Fantle K

更新日期：1994-08-01 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is a severe autosomal recessively inherited disorder caused by mutations in genes that encode components of the primary cilium and basal body. Here we show that two MKS proteins, MKS1 and meckelin, that are required for centrosome migration and ciliogenesis interact with actin-binding isof...

journal_title：Journal of cell science

authors： Dawe HR,Adams M,Wheway G,Szymanska K,Logan CV,Noegel AA,Gull K,Johnson CA

更新日期：2009-08-01 00:00:00

abstract：:IGFBP3 is a multi-functional protein that has IGF-dependent and IGF-independent actions in cultured cells. Here we show that the IGF binding domain (IBD), nuclear localization signal (NLS) and transactivation domain (TA) are conserved and functional in zebrafish Igfbp3. The in vivo roles of these domains were investig...

journal_title：Journal of cell science

authors： Zhong Y,Lu L,Zhou J,Li Y,Liu Y,Clemmons DR,Duan C

更新日期：2011-06-01 00:00:00

abstract：:Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex change...

journal_title：Journal of cell science

authors： Conway DE,Schwartz MA

更新日期：2013-11-15 00:00:00

abstract：:Bone morphogenetic protein (BMP)-6 is a member of the transforming growth factor (TGF)-(&bgr;) superfamily, and is most similar to BMP-5, osteogenic protein (OP)-1/BMP-7, and OP-2/BMP-8. In the present study, we characterized the endogenous BMP-6 signaling pathway during osteoblast differentiation. BMP-6 strongly indu...

journal_title：Journal of cell science

authors： Ebisawa T,Tada K,Kitajima I,Tojo K,Sampath TK,Kawabata M,Miyazono K,Imamura T

更新日期：1999-10-01 00:00:00

abstract：:Beta-arrestin 1 and beta-arrestin 2 are well-known negative regulators of G-protein-coupled receptor (GPCR) signaling. Upon GPCR activation, beta-arrestins translocate to the cell membrane and bind to the agonist-occupied receptors. This uncouples these receptors from G proteins and promotes their internalization, thu...

journal_title：Journal of cell science

authors： Ma L,Pei G

更新日期：2007-01-15 00:00:00

abstract：:B chromosomes are centric chromosomal fragments present in thousands of eukaryotic genomes. Because most B chromosomes are non-essential, they can be lost without consequence. In order to persist, however, some B chromosomes can impose strong forms of intra-genomic conflict. An extreme case is the paternal sex ratio (...

journal_title：Journal of cell science

authors： Swim MM,Kaeding KE,Ferree PM

更新日期：2012-11-01 00:00:00

abstract：:Mastigonemes are hair-like projections on the flagella of various kinds of lower eukaryotes. We obtained a monoclonal antibody (mAb-MAST1) to mastigonemes of Chlamydomonas reinhardtii, and found that it reacts with a single flagellar glycoprotein of about 230 kDa. Interestingly, immunofluorescence microscopy demonstra...

journal_title：Journal of cell science

authors： Nakamura S,Tanaka G,Maeda T,Kamiya R,Matsunaga T,Nikaido O

更新日期：1996-01-01 00:00:00

abstract：:Hormone-induced meiotic maturation of the Xenopus oocyte is regulated by complex changes in protein phosphorylation. It is accompanied by a stimulation in the rate of translation, manifest at the level of polypeptide chain initiation. At laser times in the maturation process, this reflects an increased ability for mRN...

journal_title：Journal of cell science

authors： Morley SJ,Pain VM

更新日期：1995-04-01 00:00:00

abstract：:Understanding the interactions between distinct epithelial cells would help us to understand the development of tissues. Drosophila imaginal discs, which are made up of two types of epithelial cells, provide good model systems for such studies. The disc proper or the columnar epithelial cells are apposed to a layer of...

journal_title：Journal of cell science

authors： Pallavi SK,Shashidhara LS

更新日期：2005-08-01 00:00:00

abstract：:Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncR...

journal_title：Journal of cell science

authors： Bensaoud C,Martins LA,Aounallah H,Hackenberg M,Kotsyfakis M

更新日期：2020-11-05 00:00:00

abstract：:The formation and maturation of membrane carriers that transport cargo from the ER to the Golgi complex involves the sequential action of the coat protein complexes COPII and COPI. Recruitment of COPI to nascent carriers requires activation of ADP-ribosylation factors by a BrefeldinA-sensitive guanine nucleotide excha...

journal_title：Journal of cell science

authors： Zhao X,Claude A,Chun J,Shields DJ,Presley JF,Melançon P

更新日期：2006-09-15 00:00:00

abstract：:SH4 domains provide bipartite membrane-targeting signals for oncogenic Src family kinases. Here we report the induction of non-apoptotic plasma membrane (PM) blebbing as a novel and conserved activity of SH4 domains derived from the prototypic Src kinases Src, Fyn, Yes and Lck as well as the HASPB protein of Leishmani...

journal_title：Journal of cell science

authors： Tournaviti S,Hannemann S,Terjung S,Kitzing TM,Stegmayer C,Ritzerfeld J,Walther P,Grosse R,Nickel W,Fackler OT

更新日期：2007-11-01 00:00:00

abstract：:The Arabidopsis thaliana ASY1 gene is essential for homologous chromosome synapsis. Antibodies specific to Asy1 protein and its homologue BoAsy1 from the related crop species Brassica oleracea have been used to investigate the temporal expression and localization of the protein in both species. Asy1 is initially detec...

journal_title：Journal of cell science

authors： Armstrong SJ,Caryl AP,Jones GH,Franklin FC

更新日期：2002-09-15 00:00:00

abstract：:Quantitative studies on the adhesive properties of transformed cells have yielded inconclusive and sometimes contradictory results. The present investigation has examined adhesive interactions between normal human fibroblasts, established as well as virus-transformed animal cell lines, and human tumour-derived cell li...

journal_title：Journal of cell science

authors： Brugmans M,Cassiman JJ,van den Berghe H

更新日期：1978-10-01 00:00:00

abstract：:We have developed a procedure for sequential silver staining and in situ hybridization to analyze the relationship between the amount of rDNA present in nucleolar organizer regions, as estimated by in situ hybridization, and their level of expression, as estimated by the silver signal. For simplicity we used cells fro...

journal_title：Journal of cell science

authors： Zurita F,Jiménez R,Burgos M,de la Guardia RD

更新日期：1998-05-01 00:00:00

abstract：:A new mouse model has been developed to study the localisation and trafficking of the glucose transporter GLUT4 in muscle. The mouse line has specific expression of a GFP and HA-epitope-tagged version of GLUT4 under the control of a muscle-specific promoter. The exofacial HA-tag has enabled fluorescent labelling of on...

journal_title：Journal of cell science

authors： Fazakerley DJ,Lawrence SP,Lizunov VA,Cushman SW,Holman GD

更新日期：2009-03-01 00:00:00

abstract：:When malignant human cells are crossed with diploid human keratinocytes, malignancy, as defined by progressive growth in vivo, is suppressed so long as the hybrid cells continue to produce involucrin, a protein that characterizes terminal differentiation in the keratinocyte. When, on continued cultivation in vitro, th...

journal_title：Journal of cell science

authors： Harris H,Bramwell ME

更新日期：1987-04-01 00:00:00

abstract：:In order to replicate, most pathogens need to enter their target cells. Many viruses enter the host cell through an endocytic pathway and hijack endosomes for their journey towards sites of replication. For delivery of their genome to the host cell cytoplasm and to avoid degradation, viruses have to escape this endoso...

journal_title：Journal of cell science

authors： Staring J,Raaben M,Brummelkamp TR

更新日期：2018-08-03 00:00:00

abstract：:The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show that PIKfyve activi...

journal_title：Journal of cell science

authors： Bissig C,Croisé P,Heiligenstein X,Hurbain I,Lenk GM,Kaufman E,Sannerud R,Annaert W,Meisler MH,Weisman LS,Raposo G,van Niel G

更新日期：2019-02-28 00:00:00

abstract：:The neuron specific Drosophila ELAV protein belongs to the ELAV family of RNA binding proteins which are characterized by three highly conserved RNA recognition motifs, an N-terminal domain, and a hinge region between the second and third RNA recognition motifs. Despite their highly conserved RNA recognition motifs th...

journal_title：Journal of cell science

authors： Yannoni YM,White K

更新日期：1999-12-01 00:00:00

abstract：:The distribution of anionic sites on the membranes of rat pancreatic B cells and of their storage granules has been studied by the use of a visual probe of cationic ferritin. Membranes of isolated storage granules possessed a net negative charge which was apparently evenly distributed; the number of anionic sites was ...

journal_title：Journal of cell science

authors： Howell SL,Tyhurst M

更新日期：1977-01-01 00:00:00

abstract：:Mammalian Delta9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the endoplasmic reticulum (ER). It is a short-lived multispanning ER membrane protein, reported to be degraded by the ubiquitin-proteasome-independent pathway. We have examined SCD1 protein degradat...

journal_title：Journal of cell science

authors： Kato H,Sakaki K,Mihara K

更新日期：2006-06-01 00:00:00

abstract：:Transcription factor E2F plays an important role in coordinating and integrating early cell cycle progression with the transcription apparatus. It is known that physiological E2F arises when a member of two families of proteins, E2F and DP, interact as E2F/DP heterodimers and that transcriptional activity is regulated...

journal_title：Journal of cell science

authors： Allen KE,de la Luna S,Kerkhoven RM,Bernards R,La Thangue NB

更新日期：1997-11-01 00:00:00

abstract：:Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell rounding and prevents neuronal differentiation, in contrast to its close relative Rac1, which stimulates cell spreading and neuritogenesis. To explain these opposing ...

journal_title：Journal of cell science

authors： Hajdo-Milasinovic A,van der Kammen RA,Moneva Z,Collard JG

更新日期：2009-06-15 00:00:00

abstract：:The coordinated trafficking and tethering of membrane cargo within cells relies on the function of distinct cytoskeletal motors that are targeted to specific subcellular compartments through interactions with protein adaptors and phospholipids. The unique actin motor myosin VI functions at distinct steps during clathr...

journal_title：Journal of cell science

authors： Tumbarello DA,Kendrick-Jones J,Buss F

更新日期：2013-06-15 00:00:00