Factors influencing the prevalence of pulmonary nodules in lung cancer screening trials: re-evaluation of a CT study.

Abstract:

:Numerous false positive findings are a problem in computed tomography based lung cancer screening trials. The potential patient-related variables that could predict the existence of such lung nodules were studied. 526 construction workers (age 38-81 yrs.) previously screened with spiral computed tomography were evaluated. Background features (age, body mass index, stature, sex, C-reactive protein, erythrocyte sedimentation rate, asbestos exposure and smoking history), reported symptoms (general condition, cough, mucous production, dyspnoea, chest pain) and findings in high resolution CT were related to the existence of nodules with logistic regression. There were 107 patients with one or more nodules recorded at least by two of the three observers. Advancing age (OR = 1.042/year, 95% CI = 1.000-1.085, p = 0.048) and dyspnoea symptom (p = 0.014) were positively associated with the existence of nodules, while smoking, asbestos exposure history and other studied parameters were not. Nodules < or = 5 mm (50 patients) were inversely associated with the maximal thickness of pleural plaques (OR = 0.384, 95% CI = 0.169-0.873, p = 0.022). No variables helpful to sample subjects for lung cancer screening studies to reduce the number of false positive findings were found. Poor inspiration or associated pathology such as thick pleura may hamper nodule detection. Further studies should focus especially on the possible effect of computer tomography technology on finding nodules.

journal_name

Ups J Med Sci

authors

Vehmas T

doi

10.3109/2000-1967-242

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

279-86

issue

3

eissn

0300-9734

issn

2000-1967

pii

http://urn.kb.se/resolve?urn=urn:nbn:se:pub:diva-2

journal_volume

113

pub_type

杂志文章
  • Intrapulmonary deposition of aerosolized Evans blue dye and liposomes in an experimental porcine model of early ARDS.

    abstract::In early ARDS (Adult Respiratory Distress Syndrome) and other inflammatory pulmonary disorders the lung might benefit from a high local deposition of an active drug, in order to optimize the local concentration without systemic side effects. In this methodological study we used pigs under controlled ventilation. The s...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739009178581

    authors: Forsgren P,Modig J,Gerdin B,Axelsson B,Dahlbäck M

    更新日期:1990-01-01 00:00:00

  • Early changes in zinc and copper metabolism in rats with alloxan diabetes of short duration after local traumatization with heat.

    abstract::Local heat trauma was induced in rats with alloxan diabetes of 3 days duration. Zinc and copper concentrations in serum, liver, heart and pancreas were estimated. After traumatization there was a decrease of the serum zinc concentration in all animals. The lowest concentration was found in the diabetic animals. Serum ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738009179172

    authors: Hallmans G,Lithner F

    更新日期:1980-01-01 00:00:00

  • Defining antibiotic resistance-towards international harmonization.

    abstract::Antimicrobial susceptibility testing with phenotypic methods requires breakpoints, i.e. a minimum inhibitory concentration (MIC) categorizing micro-organisms into susceptible, intermediately susceptible, and resistant for the relevant antimicrobial agent. Determinations of breakpoints require tools such as the underst...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.3109/03009734.2014.901446

    authors: Kahlmeter G

    更新日期:2014-05-01 00:00:00

  • Development of an evidence-based website on preconception health.

    abstract:INTRODUCTION:Many women and men lack knowledge about fertility, including timing of the fertile window, age-related decline, and lifestyle factors that may impair fertility. The Internet has become an important source of information, but evidence-based information on fertility and reproduction in Swedish on the Interne...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009734.2018.1476423

    authors: Ekstrand Ragnar M,Niemeyer Hultstrand J,Tydén T,Larsson M

    更新日期:2018-06-01 00:00:00

  • PDGF in gliomas: more than just a growth factor?

    abstract::Platelet-derived growth factor B (PDGF-B) is a growth factor promoting and regulating cell migration, proliferation, and differentiation, involved in both developmental processes and in maintaining tissue homeostasis under strict regulation. What are the implications of prolonged or uncontrolled growth factor signalin...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2012.654860

    authors: Lindberg N,Holland EC

    更新日期:2012-05-01 00:00:00

  • Implementation of a decision aid for recognition and correction of volume alterations (Recova®) in haemodialysis patients.

    abstract:BACKGROUND:Fluid overload is associated with mortality in haemodialysis patients, and 30% of patients remain fluid-overloaded after dialysis. The aim of this study was to evaluate if implementation of Recova®, a decision aid combining clinical assessment with bioimpedance spectroscopy, facilitates individualization of ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009734.2020.1804495

    authors: Stenberg J,Lindberg M,Furuland H

    更新日期:2020-11-01 00:00:00

  • New data analysis in a population study raises the hypothesis that particle size contributes to the pro-asthmatic potential of small pet animal allergens.

    abstract:BACKGROUND:The size of inhaled particles influences where they deposit and theoretically should be important for the development of airway inflammation and responsiveness. Our aim was to assess if sensitization to smaller-sized aeroallergens relates to higher prevalence of treated asthma, increased airway responsivenes...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2015.1109569

    authors: Patelis A,Dosanjh A,Gunnbjörnsdottir M,Borres MP,Högman M,Alving K,Janson C,Malinovschi A

    更新日期:2016-01-01 00:00:00

  • Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.

    abstract::Glucagon from the pancreatic α-cells is a major blood glucose-regulating hormone whose most important role is to prevent hypoglycaemia that can be life-threatening due to the brain's strong dependence on glucose as energy source. Lack of blood glucose-lowering insulin after malfunction or autoimmune destruction of the...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.3109/03009734.2016.1154905

    authors: Gylfe E

    更新日期:2016-05-01 00:00:00

  • Allergic alveolitis in Swedish farmers.

    abstract::Allergic alveolitis due to mold dust inhalation in farmers is a severe but rare disease in Scandinavia. In this report 38 cases of the disease are presented. There were 31 men and 7 women, with mean ages of 46 and 38 years respectively. Strict diagnostic criteria were used, resulting in 21 definite, 12 probable and 5 ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738909178568

    authors: Rask-Andersen A

    更新日期:1989-01-01 00:00:00

  • Tenosynovitis with rice body formation in a non-tuberculosis patient: a case report.

    abstract::In this report, we present a 68-year-old man with rice body formation in the flexor tendon sheath of the fingers without any inflammatory diseases such as tuberculosis or rheumatoid arthritis. The patient visited our institute in March 2004 with a one-month history of swelling and pain of the right distal forearm. Lab...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009730902931408

    authors: Nagasawa H,Okada K,Senma S,Chida S,Shimada Y

    更新日期:2009-01-01 00:00:00

  • Regional lymph flow in unanesthetized rabbits.

    abstract::Determinations were made of the 2-hour 22Na space and the 1 and 2 hour 51Cr EDTA spaces in a number of tissues. In regions where the two 51Cr-EDTA spaces were similar and smaller than or similar to the 22Na space the former spaces were regarded as measures of the extra-cellular volume. Using previously published data ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737909179148

    authors: Bill A

    更新日期:1979-01-01 00:00:00

  • Blood viscosity and finger systolic pressure in primary and traumatic vasospastic disease.

    abstract::Vasospastic reactions to cold have been suggested to be related to altered blood rheology, as has been reported in both primary (PVD) and traumatic (TVD) vasospastic disease. Measurements of whole blood viscosity, plasma viscosity, erythrocyte deformability and finger systolic pressure (FSP) were performed in 18 patie...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738509178639

    authors: Sandhagen B,Wegener T

    更新日期:1985-01-01 00:00:00

  • Comparison between a second generation automated multicapillary electrophoresis system with an automated agarose gel electrophoresis system for the detection of M-components.

    abstract::During the last decade, capillary electrophoresis (CE) has emerged as an interesting alternative to traditional analysis of serum, plasma and urine proteins by agarose gel electrophoresis. Initially there was a considerable difference in resolution between the two methods but the quality of CE has improved significant...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/2000-1967-219

    authors: Larsson A,Hansson LO

    更新日期:2008-01-01 00:00:00

  • Vascular resistance is decreased in the luteal rat ovary by a 20 minute continuous infusion of noradrenaline.

    abstract::The effect of a 20 min continuous infusion of noradrenaline (2 nanomoles/min) on the blood flow and vascular resistance of 2-, 6- and 11-day-old corpora lutea from adult pseudopregnant rats was studied. Pseudopregnancy was induced by mating with vasectomized male rats. The blood flow of the corpus luteum and the remai...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1517/03009734000000033

    authors: Gåfvels M,Norjavaara E,Selstam G

    更新日期:1988-01-01 00:00:00

  • Analysis of haemorheological variables--methodology and reference values.

    abstract::Routine methods are proposed for the analysis of haemorheologic variables with only one instrument, a Low Shear 30 rotational couette viscometer. The variables are plasma viscosity, whole blood apparent viscosity, erythrocyte aggregation tendency and erythrocyte fluidity. These variables, in addition to erythrocyte vo...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738909179250

    authors: Sandhagen B

    更新日期:1989-01-01 00:00:00

  • Can costs of screening for hypertension and diabetes in dental care and follow-up in primary health care be predicted?

    abstract:AIM:The purpose was to assess the direct costs of screening for high blood pressure and blood glucose in dental care and of follow-up in primary health care and, based on these data, arrive at a prediction function. Study population. All subjects coming for routine check-ups at three dental health clinics were invited ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,多中心研究

    doi:10.3109/03009734.2013.818599

    authors: Engström S,Borgquist L,Berne C,Gahnberg L,Svärdsudd K

    更新日期:2013-11-01 00:00:00

  • Tumor response evaluation criteria for HCC (hepatocellular carcinoma) treated using TACE (transcatheter arterial chemoembolization): RECIST (response evaluation criteria in solid tumors) version 1.1 and mRECIST (modified RECIST): JIVROSG-0602.

    abstract:BACKGROUND:Two standard sets of criteria are used to evaluate the tumor response of hepatocellular carcinoma (HCC): RECIST (Response Evaluation Criteria in Solid Tumors) and modified RECIST (mRECIST). The purpose was to compare two tumor response evaluation criteria, RECIST version 1.1 and mRECIST, for HCC treated usin...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,多中心研究

    doi:10.3109/03009734.2012.729104

    authors: Sato Y,Watanabe H,Sone M,Onaya H,Sakamoto N,Osuga K,Takahashi M,Arai Y,Japan Interventional Radiology in Oncology Study Group-JIVROSG.

    更新日期:2013-03-01 00:00:00

  • Treatment of unstable distal radius fractures with the volar locking plate.

    abstract:BACKGROUND:Open reduction and internal fixation using an interlocking plate system has gained popularity for the treatment of dorsally displaced distal radius fractures. PURPOSE:To evaluate the functional and radiological results of treating unstable distal radius fractures with the volar locking plate. PATIENTS AND ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2011.594183

    authors: Minegishi H,Dohi O,An S,Sato H

    更新日期:2011-11-01 00:00:00

  • Langerhans cell histiocytosis of the sternum.

    abstract::We report a rare case of Langerhans cell histiocytosis involving the sternum. The patient was a 12-year-old girl presenting with anterior chest pain and swelling. Radiographs and computed tomography showed an osteolytic lesion in the sternum. Technetium bone scintigraphy revealed increased uptakes in the sternum, the ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009730802642360

    authors: Tsuchie H,Okada K,Nagasawa H,Yano M,Nanjyo H,Shimada Y

    更新日期:2009-01-01 00:00:00

  • Studies on toxemia of pregnancy with special reference to blood pressure. I. Incidence and some characteristic features of the mothers and infants.

    abstract::An investigation was made of 150 women who were diagnosed at the Department of Obstetrics and Gynaecology, University Hospital, Uppsala in 1964-68 as having toxaemia of pregnancy. Eleven had eclampsia and the remainder pre-eclampsia. Toxaemia occurred in 0.88% (average) of all parturients during the study period. Some...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737809179108

    authors: Aberg H,Karlsson L,Melander S

    更新日期:1978-01-01 00:00:00

  • Concordant message of different inflammatory markers in patients with rheumatoid arthritis.

    abstract::The acute phase reaction is an unspecific response to inflammatory stimuli characterized by alterations in the concentration of several plasma proteins. It is of great clinical value to monitor the inflammatory state in patients with rheumatoid arthritis. The erythrocyte sedimentation rate (ESR) and C-reactive protein...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739809178943

    authors: Arvidsson NG,Gudbjörnsson B,Hällgren R,Larsson A

    更新日期:1998-01-01 00:00:00

  • Epidemiological and clinical studies on insulin resistance and diabetes.

    abstract::In Uppsala, extensive epidemiological and clinical studies on insulin resistance and diabetes have been ongoing for the past 30 years. A prospective cohort study of men born 1920-24, living in Uppsala County, was initiated during 1969-74 (the Uppsala Longitudinal Study of Adult Men, ULSAM). Risk factors for cardiovasc...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.1517/03009734000000060

    authors: Lithell H,Sundström J,Arnlöv J,Björklund K,Hänni A,Hedman A,Zethelius B,Byberg L,Kilander L,Reneland R

    更新日期:2000-01-01 00:00:00

  • Fibrinolysis inhibition after a major standardized trauma.

    abstract::The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI, alpha 2-antiplasmin). This protein exists in at least two f...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738209178409

    authors: Bagge L,Carlin G,Hjelmstedt A,Högstorp H,Jacobsson H,Modig J,Saldeen T

    更新日期:1982-01-01 00:00:00

  • Lipid metabolism of isolated mouse pancreatic islets maintained in culture at different glucose concentrations.

    abstract::The lipid metabolism of isolated mouse pancreatic islets, which had been cultured for one week at 3.3 or 16.7 mM glucose, was examined in short-term experiments performed at the end of the culture period. It was found that: a) high-glucose cultured islets oxidized palmitate at a higher rate: and b) both groups of cult...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738109179210

    authors: Berne C,Andersson A

    更新日期:1981-01-01 00:00:00

  • Light and electron microscopical studies of the substance P innervation of the dorsal column nuclei and the lateral cervical nucleus in the primate.

    abstract::In 2 monkeys of the species Macaca fascicularis the three dorsal column nuclei and the lateral cervical nucleus have been investigated immunocytochemically with antiserum against Substance P. The Substance P labeling was widely spread but rather sparse. It occurred in small structures of the size of boutons in the gra...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738909178557

    authors: Westman J

    更新日期:1989-01-01 00:00:00

  • Effect of losartan treatment on the proteinuria in normotensive patients having proteinuria due to secondary amyloidosis.

    abstract::Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not know...

    journal_title:Upsala journal of medical sciences

    pub_type: 临床试验,杂志文章

    doi:10.3109/2000-1967-142

    authors: Odabas AR,Cetinkaya R,Selcuk Y,Bilen H

    更新日期:2001-01-01 00:00:00

  • Muscle strength and balance in post-stroke patients.

    abstract::Isokinetic torque of the knee and elbow during maximal extension and flexion and isometric strength of the handgrip, as well as balance and some circulatory variables, were tested in 37 patients one year after an acute stroke. Correlations with locomotion, household work and other activities of daily living (ADL) were...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738209178405

    authors: Hamrin E,Eklund G,Hillgren AK,Borges O,Hall J,Hellström O

    更新日期:1982-01-01 00:00:00

  • Perspectives on serum acid phosphatase in prostatic disease. An evaluation of two methods.

    abstract::Acid phosphatase in serum was measured in 116 patients with prostatic disease, benign in 59 and malignant in 57 cases. Comparisons were made between radioimmunoassay (RIA) and an enzymatic method. The correlation coefficient between the respective values was 0.96 in patients with untreated prostatic cancer, indicating...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738309178446

    authors: Dedorson S,Fritjofsson A,Norlen BJ,Ronquist G

    更新日期:1983-01-01 00:00:00

  • Effect of olsalazine sodium on migrating motor complexes in the upper small bowel of human volunteers.

    abstract::The effect of a peroral dose of olsalazine sodium on the migrating motor complexes (MMC) in the upper small bowel was studied by manometry in nine healthy volunteers during fasting. Recordings were obtained from the duodenum and/or the upper jejunum for 4.0 - 7.5 h. During total baseline observation periods of 30 h, f...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738709178694

    authors: Ryde M,Gustavsson S

    更新日期:1987-01-01 00:00:00

  • Microorganisms causing pyogenic spondylitis: comparison of community and hospital-acquired types.

    abstract::Abstract Pyogenic spondylitis is a common infectious disease caused by various microorganisms. It is difficult to predict the infecting microorganism at the time of initiation of treatment. Pneumonia is generally clarified into community or hospital-acquired types based on where the infection was acquired, and the i...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2012.687406

    authors: Sasaji T,Yamada N,Iwai K

    更新日期:2012-11-01 00:00:00