Abstract:
BACKGROUND/AIMS:Parkinson's disease (PD) is an idiopathic progressive neurological disorder. Improvement in motor function of PD patients has been established with subthalamic nucleus (STN) deep brain stimulation (DBS). While variations in DBS settings (i.e. amplitude, frequency and pulse width) on motor function have been explored, little data has evaluated the relationship of DBS settings on cognitive function. This study evaluated the extent to which DBS settings were associated with cognitive function. METHODS:The study was a prospective clinical trial of STN DBS for the treatment of refractory PD. Twenty patients were evaluated once preoperatively and an average of 5 months following bilateral STN DBS. Measures included a test of motor disability, a neuropsychological test battery and subjective mood measures of anxiety and depression. RESULTS:Motor function significantly improved following bilateral STN DBS. Compared to preoperative performance, verbal fluency declined while visuoconstructional skills improved. Amplitude and pulse width were significantly correlated with measures of cognitive function. Multiple regression found DBS stimulator settings, along with anxiety, to be significant predictors of cognitive measures. CONCLUSION:Increased amplitude and pulse width and decreased anxiety were associated with improved cognitive test scores. Although preliminary, these data have potential theoretical and clinical applications.
journal_name
Stereotact Funct Neurosurgjournal_title
Stereotactic and functional neurosurgeryauthors
Schoenberg MR,Mash KM,Bharucha KJ,Francel PC,Scott JGdoi
10.1159/000163554subject
Has Abstractpub_date
2008-01-01 00:00:00pages
337-44issue
6eissn
1011-6125issn
1423-0372pii
000163554journal_volume
86pub_type
临床试验,杂志文章abstract::The possible influence of painful stimulation and morphine analgesia on hypothalamic met-enkephalin levels, and the possible correlation between this biochemical parameter and animal behaviour was studied. The results indicate that both painful stimulation and morphine treatment induce an increase in hypothalamic mete...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100635
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Hypothalamic hamartomas are associated with precocious puberty and chronic epilepsy characterized by gelastic seizures. The seizure disorder is usually refractory to most antiepileptic drugs. Gamma knife surgery has emerged as an alternative to microsurgical removal or radiofrequency ablation to improve seiz...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000094036
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:In nonresectable glioblastoma (GBM), stereotactic biopsies are performed to retrieve tissue for diagnostic purposes. The analysis of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation adds prognostic and predictive information. OBJECTIVES:The aim of the study was to detect confounding factor...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000360582
更新日期:2014-01-01 00:00:00
abstract::A 25-year-old woman with a large acoustic schwannoma underwent surgical excision 18 months after Gamma Knife radiosurgery because of transient expansion of the tumor causing ataxia. Histopathologial investigation by the TUNEL method revealed the presence of some apoptotic cells. The findings were compared with finding...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000056411
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). OBJECTIVES:To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS:Res...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000455930
更新日期:2017-01-01 00:00:00
abstract::We present a system for surgical navigation using stereo overlays in the operating microscope aligned to the operative scene. This augmented reality system provides 3D information about nearby structures and offers a significant advancement over pointer-based guidance, which provides only the location of one point and...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000029708
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:We have developed an overlaid three-dimensional image (Volumegraph)-guided navigation system that allows navigation during operative procedures. The three-dimensional image is superimposed on the patient's head and body via a semi-transparent mirror. The Volumegraph can display three-dimensional images in the...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000099897
更新日期:1997-01-01 00:00:00
abstract::Today's image guidance systems are the foundation of minimally invasive diagnosis and therapy and are the basis for the rational design of the neurosurgical operating room of the future. The building blocks of this procedural arena will be (1) high-resolution MR/CT anatomic imaging supplemented with (2) functional ima...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000029773
更新日期:1999-01-01 00:00:00
abstract::The aim of the study was to investigate if laser Doppler perfusion monitoring (LDPM) can be used in order to differentiate between gray and white matter and to what extent microvascular perfusion can be recorded in the deep brain structures during stereotactic neurosurgery. An optical probe constructed to fit in the L...
journal_title:Stereotactic and functional neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1159/000107360
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:In subthalamic nucleus (STN) deep brain stimulation (DBS) lead implantation, it is still controversial whether it is more appropriate to employ indirect or direct methods in magnetic resonance imaging (MRI)-based tentative targeting and to select single- or multiple-track recording in electrophysiologic...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000120430
更新日期:2008-01-01 00:00:00
abstract::The true accuracy of MRI scanners utilized for target acquisition in functional stereotaxis remains undefined. We have performed pallidotomies at the Loma Linda University Medical Center using both MRI and MRI concomitant with positive contrast ventriculography. A retrospective study of 33 cases revealed significant d...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000098897
更新日期:1995-01-01 00:00:00
abstract::In selected patients with recurrent malignant glioma, interstitial brachytherapy has been advocated as an effective method for tumor control and prolonged survival. We are presenting our results with brachytherapy in patients with recurrent glioma, and comparing this technique with cytoreductive surgery. Twenty patien...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100320
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND/AIMS:Our study aimed to evaluate the efficiency and morbidity of Gamma Knife radiosurgery (GKS) in the treatment of hemorrhagic brainstem cavernous malformations (CMs). METHODS:We included in this study all patients who underwent GKS for the treatment of a hemorrhagic brainstem CM(s) in our institution betw...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000452844
更新日期:2016-01-01 00:00:00
abstract::Six patients with brain tumors within or near the primary motor cortex underwent preoperative functional magnetic resonance imaging (fMRI) and intraoperative cortical mapping, and the accuracy of those techniques for localization of the primary motor cortex and motor function beside the tumor were determined by compar...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000088160
更新日期:2005-01-01 00:00:00
abstract::A Leksell Gamma Unit was commissioned and a Lars Leksell Center for Radiosurgery was established at the University of Virginia Health Sciences Center in March 1989. At that time a formal quality assurance program designed for the Leksell Gamma Unit was put into effect. This paper will review the components of suggeste...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000099561
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) has recently been suggested for treatment of medication-unresponsive gait and axial symptoms in Parkinson's disease. Patients with the rare primary progressive freezing gait disorder (PPFG) have similar disabling symptoms and few therapeutic options...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000268742
更新日期:2010-01-01 00:00:00
abstract::A simple technique has been designed which identifies the gantry isocenter and aligns the laser beams to the isocenter of the gantry within 3-5 min with an error of less than 0.75 mm, depending upon the accuracy of gantry rotation. ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000099516
更新日期:1989-01-01 00:00:00
abstract::The authors assessed whether gamma knife radiosurgery is effective for patients with acromegaly where the pituitary tumors invaded the cavernous sinus. Radiosurgery was performed on 9 patients (average of 20 Gy to the tumor margin), 8 of whom had already undergone transsphenoidal surgery and/or craniotomy with occasio...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000066721
更新日期:2001-01-01 00:00:00
abstract::Autologous transplantation of the superior cervical ganglion (SCG) into the caudate nuclei of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian monkey was studied in regard to animal behavior and catecholamine (CA) metabolites in cerebrospinal fluid. Monkeys which had undergone autotransplantation of t...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100231
更新日期:1990-01-01 00:00:00
abstract::Out of 57 patients operated for intractable epilepsy of the central region, 8 harbored an indolent glioma (7 dysembryoplastic neuroepithelial tumors, 1 ganglioglioma). Mapping of the sensorimotor area with depth electrodes implanted for stereoelectroencephalographic exploration demonstrated no or abnormal motor respon...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000099880
更新日期:1997-01-01 00:00:00
abstract::We report a case of induced oscillopsia caused by deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN). Recent reports have described involuntary oscillopsia during DBS of the PPN that patients have described as trembling vision. Here we substantiate this observation using infra-red eye tracking. It has ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000335871
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Interpreting the postoperative electroencephalographic (EEG) driving response (DR) as an indicator of electrode placement within the thalamic nucleus in deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) for refractory epilepsy is controversial. MATERIALS AND METHODS:We retrospective...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000449012
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Balloon compression of the gasserian ganglion has been a well-established percutaneous treatment of trigeminal neuralgia since the 1980s. However, puncture of the foramen ovale by conventional single-plane fluoroscopy can be difficult in cases of local anatomic abnormalities. CASE PRESENTATION:We present th...
journal_title:Stereotactic and functional neurosurgery
pub_type:
doi:10.1159/000509821
更新日期:2020-09-16 00:00:00
abstract:INTRODUCTION:The primary goal of stereotactic systems in deep brain stimulation (DBS) surgery is accurate delivery of a DBS lead to a target identified on imaging. Thus, it is critical to understand the accuracy of the stereotactic systems and the factors which may be associated with a decrease in accuracy. METHODS:Ni...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000316761
更新日期:2010-01-01 00:00:00
abstract::At the KUL University of Leuven a workstation for the planning of neurosurgical stereotactic procedures has been developed. Its benefits are illustrated in three exemplary cases. The CT and/or MR images, acquired under stereotactic conditions, are transmitted via a PACS network (picture archiving and communication sys...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100284
更新日期:1994-01-01 00:00:00
abstract::Although technological advances have reduced device-related complications, DBS surgery still carries a significant risk of transient and permanent complications. We report our experience in 86 patients and 149 DBS implants. Patients with Parkinson's disease, essential tremor and dystonia were treated. There were 8 per...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000064600
更新日期:2001-01-01 00:00:00
abstract::To evaluate the role of Gamma Knife radiosurgery as the first surgical therapy in the management of medically refractory trigeminal neuralgia, we reviewed outcomes on our first 23 patients who had radiosurgery as primary surgical therapy. These patients represented 19% of our overall series. Mean patient age was 66 ye...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000056421
更新日期:1998-10-01 00:00:00
abstract::As a part of the systematic analysis of parameters involved in electrical epidural spinal cord stimulation therapy, distribution of paresthesiae in accordance with the position of contacts, as related to midline and vertebral level of contacts, was investigated. A preliminary analysis performed for 266 combinations ha...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100632
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:One of the many reasons why lesional surgery for movement disorders has been more or less abandoned may have been the difficulty in predicting the shape and size of the stereotactic radiofrequency (RF) lesion. OBJECTIVES:To analyse the contribution of various RF coagulation parameters towards the volume of ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000338249
更新日期:2012-01-01 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000343148
更新日期:2013-01-01 00:00:00