Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder.

Abstract:

BACKGROUND:Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) has recently been suggested for treatment of medication-unresponsive gait and axial symptoms in Parkinson's disease. Patients with the rare primary progressive freezing gait disorder (PPFG) have similar disabling symptoms and few therapeutic options. We report here on our experience with PPN DBS in treating a 76-year-old man with medication-refractory PPFG. METHODS:The patient was treated with staged PPN DBS and underwent careful pre- and postoperative clinical evaluations up to 12 months after surgery. RESULTS:PPN DBS resulted in only mild improvement in symptoms after 12 months of stimulation. CONCLUSION:In this single case of a patient with PPFG, PPN DBS served only a limited role in treating his symptoms and adds to the very limited published literature describing patients treated with DBS at this brain target.

authors

Ostrem JL,Christine CW,Glass GA,Schrock LE,Starr PA

doi

10.1159/000268742

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

51-5

issue

1

eissn

1011-6125

issn

1423-0372

pii

000268742

journal_volume

88

pub_type

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