Pathobiology of cerebral gliomas in children and the role of radiosurgery.

Abstract:

:Twenty-five gliomas of the cerebral hemisphere in children were examined. Most hemispheric gliomas in children have relatively clear margins and less infiltrative potential. Radiosurgery has a role in the treatment of these tumors in addition to reducing the risk of radiation injuries developing later. Fifteen patients were alive 1-27 years (mean 8.4) following treatment and 10 patients died. Histologic examination demonstrated 10 differentiated gliomas, 10 poorly differentiated gliomas and 5 other gliomas. Most tumors had relatively clear margins on computed tomography and/or magnetic resonance images, and peritumoral edema was slight. In 9 autopsy cases, tumor dissemination and/or metastasis were seen in 7. However, tumor infiltration was not extensive, and clear tumor margins were found in some cases. Thus, cerebral gliomas in children have relatively clear margins and low infiltrative potential. Radiosurgery has a role in the treatment of these tumors.

authors

Inoue HK,Kohga H,Zama A,Hirato M,Shibazaki T,Andou Y,Ohye C

doi

10.1159/000099819

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

278-87

eissn

1011-6125

issn

1423-0372

journal_volume

66 Suppl 1

pub_type

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