Paradoxical labeling of radiosurgically treated quiescent tumors with Ki67, a marker of cellular proliferation.

Abstract:

:Ki67 (also known as MIB) is a monoclonal antibody staining agent, which is routinely used as a marker of cellular proliferation. It is used to evaluate the proliferative potential of malignant tumors, since it is thought to stain only those cells undergoing active division. The paradoxical elevation of the Ki67 labeling index observed in radiosurgically treated benign and malignant tumors is reported. Ten patients, who had previously undergone either linac or Gamma Knife radiosurgery, underwent surgical resection for a radiographically quiescent tumor. One patient underwent autopsy after dying from complications of radiosurgery. All were thought to be suffering from adverse radiation effect (ARE) and were refractory to conservative management. None were thought to have a recurrent tumor. All of the resected tumors were subjected to analysis with Ki67 staining. Despite the radiographic stability of the tumors, all manifested significantly elevated populations of cells exhibiting positivity for Ki67 antigen. This staining pattern would suggest a significant proliferative potential, which did not match the observed clinical course. The literature is reviewed and possible mechanisms to explain the paradoxical findings are presented.

authors

Jennelle R,Gladson C,Palmer C,Guthrie B,Markert J

doi

10.1159/000056438

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

45-52

eissn

1011-6125

issn

1423-0372

pii

56438

journal_volume

72 Suppl 1

pub_type

杂志文章
  • Computerized brain atlas in functional neurosurgery.

    abstract::Computerized brain atlas is a new application area in the practical use of stereotactic neurosurgery. Our approach provides a solution for the straightforward definition of a coordinate system (CA-CP), localization of the selected target point, trepanation points and trajectory transformation of the stereotactic elect...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099858

    authors: Sramka M,Ruzicky E,Novotny M

    更新日期:1997-01-01 00:00:00

  • Gamma Knife radiosurgery in cerebral arteriovenous malformations: postobliteration nidus changes observed on neurodiagnostic imaging.

    abstract::Computed tomographic (CT), magnetic resonance (MR), MR angiographic and angiographic images, obtained after complete nidus obliteration had been angiographically confirmed, were reviewed in 9 patients who had undergone Gamma Knife treatment for cerebral arteriovenous malformations (AVMs). The period between angiograph...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098772

    authors: Yamamoto M,Jimbo M,Ide M,Lindquist C,Steiner L

    更新日期:1995-01-01 00:00:00

  • Modified Fluorodeoxyglucose Metabolism in Motor Circuitry by Subthalamic Deep Brain Stimulation.

    abstract:BACKGROUND:Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). OBJECTIVES:To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS:Res...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000455930

    authors: Cao C,Zhang H,Li D,Zhan S,Zhang J,Zhang X,Zuo C,Sun B

    更新日期:2017-01-01 00:00:00

  • Radiosurgical treatment of meningiomas.

    abstract::From January 1992 to November 1996, 17 patients with the diagnosis of intracranial meningioma underwent radiosurgical treatment. Of these, 7 patients were treated using a Linac-based system (group 1), and 10 using the Leksell Gamma Knife unit (group 2). The follow-up ranged between 12 and 48 (median 33) months for gro...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099869

    authors: Zamorano L,Saenz A,Matter A,Buciuc R,Gaspar L,Fontanesi J,Garzon A,Diaz F

    更新日期:1997-01-01 00:00:00

  • Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson's disease.

    abstract:BACKGROUND/AIMS:Parkinson's disease (PD) is an idiopathic progressive neurological disorder. Improvement in motor function of PD patients has been established with subthalamic nucleus (STN) deep brain stimulation (DBS). While variations in DBS settings (i.e. amplitude, frequency and pulse width) on motor function have ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1159/000163554

    authors: Schoenberg MR,Mash KM,Bharucha KJ,Francel PC,Scott JG

    更新日期:2008-01-01 00:00:00

  • Radiobiological effects of gamma knife radiosurgery on brain tumors studied in autopsy and surgical specimens.

    abstract::To elucidate the radiobiological effect of Gamma Knife radiosurgery on brain tumors, we performed a histological study on nine cases. In two, the material was obtained at autopsy and in seven following surgery. In the central region of the radiation field, destructive changes occurred both in tumor cells and in vessel...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099695

    authors: Hirato M,Hirato J,Zama A,Inoue H,Ohye C,Shibazaki T,Andou Y

    更新日期:1996-01-01 00:00:00

  • Successful bilateral subthalamic nucleus stimulation for segmental dystonia after unilateral pallidotomy.

    abstract:BACKGROUND:Several subcortical structures have been targeted for surgical treatment of dystonia, including motor thalamus, internal segment of globus pallidus (GPi), and more recently, the subthalamic nucleus (STN). Deep brain stimulation of GPi is currently the preferred surgical treatment, but it is unclear if target...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000112428

    authors: Novak KE,Nenonene EK,Bernstein LP,Vergenz S,Cozzens JW,Rezak M

    更新日期:2008-01-01 00:00:00

  • Chronic intractable epilepsy associated with a tumor located in the central region: functional mapping data and postoperative outcome.

    abstract::Out of 57 patients operated for intractable epilepsy of the central region, 8 harbored an indolent glioma (7 dysembryoplastic neuroepithelial tumors, 1 ganglioglioma). Mapping of the sensorimotor area with depth electrodes implanted for stereoelectroencephalographic exploration demonstrated no or abnormal motor respon...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099880

    authors: Devaux B,Chassoux F,Landré E,Turak B,Daumas-Duport C,Chagot D,Gagnepain JP,Chodkiewicz JP

    更新日期:1997-01-01 00:00:00

  • Continuous intrathecal clonidine administration for the treatment of neuropathic pain.

    abstract::In many cases, the treatment of neuropathic pain by intrathecal opioids fails to meet expectations. In a trial involving 10 patients, the intrathecal administration of clonidine combined with opioids in the treatment of chronic pain was introduced in our department for the first time. Eight patients with neuropathic p...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1159/000048402

    authors: Uhle EI,Becker R,Gatscher S,Bertalanffy H

    更新日期:2000-01-01 00:00:00

  • Analysis of neuroelectric implant integrity.

    abstract::A 10-year follow-up study of neuroelectric implant integrity has been completed for 27 subjects who were treated for movement disorders associated with cerebral palsy. Data used for analysis included X-ray material, clinical data, and results from electrophysiological testing. Of the 21 subjects with subcutaneous rece...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099487

    authors: Harris GF,Hemmy DC,Coad JE,Mothkur SR,Weber RC

    更新日期:1989-01-01 00:00:00

  • Quantitative on-line analysis of physiological data for lesion placement in pallidotomy.

    abstract::A computerized method of determining the focal point of electrical activity in the pallidum of parkinsonian patients was developed using on-line quantitative physiological data analysis. Thirty patients in a series of 70 were studied in depth. Neuronal activity was recorded from the pallidum using a semi-microelectrod...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000048378

    authors: Lehman RM,Micheli-Tzanakou E,Medl A,Hamilton JL

    更新日期:2000-01-01 00:00:00

  • A community-centric internet portal for stereotactic and functional neurosurgery with a probabilistic functional atlas.

    abstract:OBJECTIVE:This paper describes an Internet portal for stereotactic and functional neurosurgery with a probabilistic functional atlas (PFA) calculated from electrophysiological and neuroimaging data. This portal enables (1) data sharing among neurosurgeons; (2) the calculation of probabilistic functional maps of stereot...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000069499

    authors: Nowinski WL,Belov D,Benabid AL

    更新日期:2002-01-01 00:00:00

  • Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation.

    abstract:BACKGROUND/AIMS:There are reports that microelectrode recording (MER) can be performed under certain anesthetized conditions for functional confirmation of the optimal deep brain stimulation (DBS) target. However, it is generally accepted that anesthesia affects MER. Due to a potential role of local field potentials (L...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000492231

    authors: Malekmohammadi M,Sparks H,AuYong N,Hudson A,Pouratian N

    更新日期:2018-01-01 00:00:00

  • Spinal cord stimulation to abort painful spasms of atypical stiff limb syndrome.

    abstract::Stiff limb syndrome (SLS) is a rare chronic condition which can result in significant debility. We report the case of a 44-year-old man suffering from severe painful spasms in his right leg with a diagnosis of SLS. He had been initially treated for his pain with a spinal cord stimulator but presented with exacerbation...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000313871

    authors: Ughratdar I,Sivakumar G,Basu S

    更新日期:2010-01-01 00:00:00

  • Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome.

    abstract:OBJECTIVE:Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) is an alternative therapy in ameliorating the clinical symptoms of primary Meige syndrome. Nevertheless, proof of its efficacy and safety is insufficient due to several case reports and small-sample clinical studies. This study ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000504861

    authors: Tian H,Yu Y,Zhen X,Zhang L,Yuan Y,Zhang B,Wang L

    更新日期:2019-01-01 00:00:00

  • Gamma Knife Radiosurgery of Brainstem Cavernous Malformations.

    abstract:BACKGROUND/AIMS:Our study aimed to evaluate the efficiency and morbidity of Gamma Knife radiosurgery (GKS) in the treatment of hemorrhagic brainstem cavernous malformations (CMs). METHODS:We included in this study all patients who underwent GKS for the treatment of a hemorrhagic brainstem CM(s) in our institution betw...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000452844

    authors: Aboukais R,Estrade L,Devos P,Blond S,Lejeune JP,Reyns N

    更新日期:2016-01-01 00:00:00

  • A simple stereotactic method for frameless deep brain stimulation.

    abstract:BACKGROUND:Deep brain stimulation (DBS) is widely used to treat advanced Parkinson's disease, other movement and psychiatric disorders. DBS implantation requires application of a stereotactic frame throughout a lengthy procedure, making it uncomfortable and tiring. We designed a stereotactic cube to stage the operation...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000096633

    authors: Eljamel MS,Tulley M,Spillane K

    更新日期:2007-01-01 00:00:00

  • Stereotactic radiosurgery: current status and future trends.

    abstract::The first Gamma Knife was installed in Stockholm in 1968 after nearly two decades of development. Following the opening of the Gamma Knife facility in Pittsburgh in 1987, radiosurgery has seen an explosive expansion. Along with this expansion there has been a development of alternative technologies, of which the most ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Leksell DG

    更新日期:1993-01-01 00:00:00

  • Gamma Knife radiosurgery of primary and metastatic malignant brain tumors, a preliminary report.

    abstract::Between February 1993 and March 1994, 75 metastases, 16 gliomas and 2 AIDS-related malignant lymphomas were treated with Gamma Knife radiosurgery. Metastatic brain tumors (54% lung cancer, 14% breast cancer, 13.5% melanoma) were the most frequent and clinically rewarding cases. So-called local control was achieved in ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098764

    authors: Gerosa MA,Nicolato A,Berlucchi S,Piovan E,Zampieri PG,Pasoli A,Foroni R,Giri MG,Marchini G,Babighian S

    更新日期:1995-01-01 00:00:00

  • A 13-year experience with epilepsy surgery.

    abstract::Between 1985 and 1997, 563 therapeutic craniotomies were performed: 311 anterior temporal (ATL) and 158 extramesial temporal (XMT) resections, 67 callosotomies, 20 hemispherectomies and 7 multiple subpial transections. Sixty-seven percent of nonlesional ATL cases were seizure free (SF), and 76% of nonlesional ATL case...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000029763

    authors: Smith JR,Lee MR,Jenkins PD,King DW,Murro AM,Park YD,Lee GP,Meador KJ,Loring DW

    更新日期:1999-01-01 00:00:00

  • Implementation of a stereotactic microscope using an optically coupled tracking system.

    abstract::Image-directed neurosurgical systems allow the correlation of a point in the operative field to a corresponding point on the patient's CT/MR scans. We have modified a surgical microscope by mounting three light-emitting diodes (LEDs) on a small frame attached to the microscope. The operative field was registered to th...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099675

    authors: Hirschberg H

    更新日期:1996-01-01 00:00:00

  • Thalamic deep brain stimulation for the treatment of action myoclonus caused by perinatal anoxia.

    abstract:BACKGROUND:Perinatal anoxia rarely causes myoclonus as the main neurologic abnormality. The exact neuronal mechanism underlying myoclonus induced by perinatal anoxia remains unknown. Some studies have indicated that the development of involuntary movements may be related to the maturation of the thalamus after birth. ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000315464

    authors: Kobayashi K,Katayama Y,Otaka T,Obuchi T,Kano T,Nagaoka T,Kasai M,Oshima H,Fukaya C,Yamamoto T

    更新日期:2010-01-01 00:00:00

  • Neuropsychological outcome following pallidotomy and thalamotomy for Parkinson's disease.

    abstract::Cognitive and emotional outcomes were assessed after unilateral posteroventral pallidotomy (PVP) and ventral intermediate nucleus thalamotomy (Vim-Th) in patients suffering from idiopathic Parkinson's disease (PD). PVP was performed on 12 PD patients (8 men and 4 women, mean age 56.4 years, 6 left lesions and 6 right ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000056458

    authors: Fukuda M,Kameyama S,Yoshino M,Tanaka R,Narabayashi H

    更新日期:2000-01-01 00:00:00

  • Using Preimplanted Deep Brain Stimulation Electrodes for Rescue Thalamotomy in a Case of Holmes Tremor: A Case Report and Review of the Literature.

    abstract:BACKGROUND:Chronic stimulation of the thalamus is a surgical option in the management of intractable Holmes tremor. Patients with deep brain stimulation (DBS) can encounter infection as a postoperative complication, necessitating explantation of the hardware. Some studies have reported on the technique and the resultin...

    journal_title:Stereotactic and functional neurosurgery

    pub_type:

    doi:10.1159/000506083

    authors: Razmkon A,Yousefi O,Vaidyanathan J

    更新日期:2020-01-01 00:00:00

  • Volumegraph (overlaid three-dimensional image-guided navigation). Clinical application of augmented reality in neurosurgery.

    abstract:OBJECTIVE:We have developed an overlaid three-dimensional image (Volumegraph)-guided navigation system that allows navigation during operative procedures. The three-dimensional image is superimposed on the patient's head and body via a semi-transparent mirror. The Volumegraph can display three-dimensional images in the...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099897

    authors: Iseki H,Masutani Y,Iwahara M,Tanikawa T,Muragaki Y,Taira T,Dohi T,Takakura K

    更新日期:1997-01-01 00:00:00

  • Gamma knife stereotactic radiosurgical boost for patients treated primarily with neutron radiotherapy for salivary gland neoplasms.

    abstract:OBJECT:To determine the feasibility of utilizing a Gamma Knife stereotactic boost for patients at high risk of local recurrence from minor salivary gland tumors invading the base of skull. METHODS:Eight patients with minor salivary gland tumors invading the base of skull were treated with primary neutron radiotherapy ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000077457

    authors: Douglas JG,Silbergeld DL,Laramore GE

    更新日期:2004-01-01 00:00:00

  • Stereotactic management of craniopharyngiomas.

    abstract::The authors present a series of 47 patients with craniopharyngiomas treated by stereotaxy in the past 15 years. There was no mortality nor immediate postoperative morbidity in the treatment of the cystic portion of the neoplasm. Intracavitary colloidal yttrium (90Y) was extremely effective in obtaining long-lasting di...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098691

    authors: Frank F,Fabrizi AP,Frank G,Fioravanti A

    更新日期:1995-01-01 00:00:00

  • A miniature optical neuronavigation system for CT-guided stereotaxy.

    abstract:BACKGROUND AND OBJECTIVE:Neuronavigation devices have progressed over the past 2 decades, but logistical limitations remain for many stereotactic procedures. We describe our technique and accuracy for a novel miniature optical tracking system which overcomes these limitations. METHOD:The minioptical tracking system us...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000354819

    authors: von Jako CR,Perlaki G,Orsi G,Schwarcz A,Dóczi T

    更新日期:2014-01-01 00:00:00

  • Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder.

    abstract:BACKGROUND:Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) has recently been suggested for treatment of medication-unresponsive gait and axial symptoms in Parkinson's disease. Patients with the rare primary progressive freezing gait disorder (PPFG) have similar disabling symptoms and few therapeutic options...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000268742

    authors: Ostrem JL,Christine CW,Glass GA,Schrock LE,Starr PA

    更新日期:2010-01-01 00:00:00

  • MRI-guided stereotactic thalamotomy for cerebral palsy patients with mixed dyskinesia.

    abstract::The author has performed 108 stereotactic thalamotomies using MRI (MGSTs) without ventriculography in 77 cerebral palsy (CP) patients with dyskinesia(s) from January 1992 to January 1997. The clinical results were verified in terms of improvement of major preoperative symptom and patient's (or relative's) satisfaction...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099891

    authors: Lee KH

    更新日期:1997-01-01 00:00:00