Gamma Knife radiosurgery of primary and metastatic malignant brain tumors, a preliminary report.


:Between February 1993 and March 1994, 75 metastases, 16 gliomas and 2 AIDS-related malignant lymphomas were treated with Gamma Knife radiosurgery. Metastatic brain tumors (54% lung cancer, 14% breast cancer, 13.5% melanoma) were the most frequent and clinically rewarding cases. So-called local control was achieved in almost all patients, the vast majority showing neurological improvement associated with radiological disappearance or dramatic shrinkage of the tumor within 9-12 weeks from treatment. According to our modified 'Pittsburgh' protocol, we have treated up to four distinct intracranial lesions, up to a total maximum volume of 20 cm3, with an average surface dose of 25 Gy, with or without additional whole brain radiotherapy (WBR). Preliminary follow-up data seem to confirm increased quality of life and survival rates. The results were particularly striking whenever primary tumors were under control, and were poorly influenced by associated WBR. Gamma Knife treatment was also performed in a selected group of patients with small-to-medium-sized, well-defined, histologically proven, cerebral gliomas. The main indications for radiosurgery were high-risk surgery, multifocal disease, ventricular seeding and unresected or recurrent tumor. The prescription doses ranged from 18 to 30 Gy, with a mean of 27 Gy. Low-grade astrocytomas (9/16 cases) showed the better clinical and radiological response to treatment, with neurological recovery and significant reduction in tumor volume within 3-5 months in 5 of the 9 patients. In 4 of 7 high-grade gliomas, there was little or no response. However, an impressive radiological regression with full clinical recovery was observed in 2 high-grade cases with small tumor volumes: a recurrent, anaplastic 'mixed glioma' of the pineal region and a double ventricular seeding of a previously operated anaplastic astrocytoma.


Gerosa MA,Nicolato A,Berlucchi S,Piovan E,Zampieri PG,Pasoli A,Foroni R,Giri MG,Marchini G,Babighian S




Has Abstract,Author List Incomplete


1995-01-01 00:00:00








64 Suppl 1


  • Development of a Standardized Cranial Phantom for Training and Optimization of Functional Stereotactic Operations.

    abstract:BACKGROUND:In recent years, simulations based on phantom models have become increasingly popular in the medical field. In the field of functional and stereotactic neurosurgery, a cranial phantom would be useful to train operative techniques, such as stereo-electroencephalography (SEEG), to establish new methods as well...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Krüger MT,Coenen VA,Egger K,Shah M,Reinacher PC

    更新日期:2018-01-01 00:00:00

  • Implementation of a stereotactic microscope using an optically coupled tracking system.

    abstract::Image-directed neurosurgical systems allow the correlation of a point in the operative field to a corresponding point on the patient's CT/MR scans. We have modified a surgical microscope by mounting three light-emitting diodes (LEDs) on a small frame attached to the microscope. The operative field was registered to th...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Hirschberg H

    更新日期:1996-01-01 00:00:00

  • Intraoperative functional magnetic resonance imaging for monitoring the effect of deep brain stimulation in patients with obsessive-compulsive disorder.

    abstract:OBJECTIVES:To investigate the effects of low- and high-frequency deep brain stimulation (DBS) on the nucleus accumbens (ACC) and the adjacent internal capsule in 3 patients with obsessive-compulsive disorder (OCD) using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) under intraope...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Hiss S,Hesselmann V,Hunsche S,Kugel H,Sturm V,Maintz D,Visser-Vandewalle V,Liebig T,Maarouf M

    更新日期:2015-01-01 00:00:00

  • The efficacy of linear accelerator radiosurgery in the management of patients with Cushing's disease.

    abstract::We identified 35 patients who had undergone stereotactic radiosurgery (SRS) for their biochemically proven Cushing's disease in order to assess the efficacy of SRS with regard to control of hypercortisolism, improvement of clinical features and prevention of tumor progression, and subsequent incidence of hypopituitari...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Devin JK,Allen GS,Cmelak AJ,Duggan DM,Blevins LS

    更新日期:2004-01-01 00:00:00

  • CT/MR image fusion in the postoperative assessment of electrodes implanted for deep brain stimulation.

    abstract:BACKGROUND/AIMS:Stereotactic postoperative imaging is essential for verification of the position of electrodes implanted for deep brain stimulation (DBS). MRI offers superior visualisation of the DBS targets relative to CT, but previous adverse incidents have heightened concerns about risks of postoperative MRI. Preope...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: O'Gorman RL,Jarosz JM,Samuel M,Clough C,Selway RP,Ashkan K

    更新日期:2009-01-01 00:00:00

  • Topographic analysis of the gyral patterns of the central area.

    abstract::Great advances in imaging technology allows the surgeon to visualize the entire brain surface during surgery. However, the cerebral convolutions are extremely complex, so that it is often difficult to define the central area precisely. Using the curvilinear reconstruction technique (Gyroview) and MRI, we have analyzed...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Lee U,Bastos AC,Alonso-Vanegas MA,Morris R,Olivier A

    更新日期:1998-01-01 00:00:00

  • Using Preimplanted Deep Brain Stimulation Electrodes for Rescue Thalamotomy in a Case of Holmes Tremor: A Case Report and Review of the Literature.

    abstract:BACKGROUND:Chronic stimulation of the thalamus is a surgical option in the management of intractable Holmes tremor. Patients with deep brain stimulation (DBS) can encounter infection as a postoperative complication, necessitating explantation of the hardware. Some studies have reported on the technique and the resultin...

    journal_title:Stereotactic and functional neurosurgery



    authors: Razmkon A,Yousefi O,Vaidyanathan J

    更新日期:2020-01-01 00:00:00

  • Radiobiological effects of gamma knife radiosurgery on brain tumors studied in autopsy and surgical specimens.

    abstract::To elucidate the radiobiological effect of Gamma Knife radiosurgery on brain tumors, we performed a histological study on nine cases. In two, the material was obtained at autopsy and in seven following surgery. In the central region of the radiation field, destructive changes occurred both in tumor cells and in vessel...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Hirato M,Hirato J,Zama A,Inoue H,Ohye C,Shibazaki T,Andou Y

    更新日期:1996-01-01 00:00:00

  • Comparison of radiosurgery planning modalities for acoustic neuroma with regard to conformity and mean target dose.

    abstract:PURPOSE:To evaluate dose conformity and mean target dose in light of previous comparative studies and state-of-the-art radiosurgery delivery modalities. MATERIALS AND METHODS:Seven patients with acoustic neuromas deemed clinically suitable for linear accelerator or Gamma Knife radiosurgery were planned such that the m...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Perks JR,El-Hamri K,Blackburn TP,Plowman PN

    更新日期:2005-01-01 00:00:00

  • Plasticity in human somatosensory thalamus as a result of deafferentation.

    abstract::Experimental studies indicate that deafferentation results in reorganization of the somatosensory map at various levels of the CNS, such that the representation of a body part adjacent to a region that is denervated expands into the deafferented area. Recent data suggest that in the human this occurs at the cortical l...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Kiss ZH,Dostrovsky JO,Tasker RR

    更新日期:1994-01-01 00:00:00

  • The Medial Subthalamic Nucleus Border as a New Anatomical Reference in Stereotactic Neurosurgery for Parkinson's Disease.

    abstract:INTRODUCTION:The intersection of Bejjani's line with the well-delineated medial subthalamic nucleus (STN) border on MRI has recently been proposed as an individualized reference in subthalamic deep brain stimulation (DBS) surgery for Parkinson's disease (PD). We, therefore, aimed to investigate the applicability across...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Bolier E,Bot M,van den Munckhof P,Pal G,Sani S,Verhagen Metman L

    更新日期:2020-11-18 00:00:00

  • Trigeminal Neuralgia Secondary to Meningiomas and Vestibular Schwannoma Is Improved after Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis.

    abstract:INTRODUCTION:Trigeminal neuralgia (TN) secondary to tumors is encountered in up to 6% of patients with facial pain syndromes and is considered to be associated with tumors affecting the trigeminal nerve pathways. The most frequent are meningiomas and vestibular schwannomas (VS). Stereotactic radiosurgery (SRS) has emer...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章,评审


    authors: Peciu-Florianu I,Régis J,Levivier M,Dedeciusova M,Reyns N,Tuleasca C

    更新日期:2020-09-09 00:00:00

  • Bilateral subthalamic deep brain stimulation for camptocormia associated with Parkinson's disease.

    abstract:BACKGROUND:Few multiple case studies of the effects of deep brain stimulation for camptocormia associated with Parkinson's disease have been reported. Although deep brain stimulation was in some cases not effective against camptocormia, it is unclear in which types of patients it was effective in treating camptocormia....

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Asahi T,Taguchi Y,Hayashi N,Hamada H,Dougu N,Takashima S,Tanaka K,Endo S

    更新日期:2011-01-01 00:00:00

  • Interstitial hyperthermia of malignant brain tumors by an implant heating system using stereotactic techniques.

    abstract::Interstitial hyperthermia of malignant brain tumors has been produced by a heated ferromagnetic implant with a low Curie point. Induction heating of the implant, which is stereotactically implanted in a tumor, is obtained by eddy currents in a high-frequency magnetic field. Safe, repeated and long-term treatment of 35...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Kobayashi T,Kida Y

    更新日期:1992-01-01 00:00:00

  • Paradoxical labeling of radiosurgically treated quiescent tumors with Ki67, a marker of cellular proliferation.

    abstract::Ki67 (also known as MIB) is a monoclonal antibody staining agent, which is routinely used as a marker of cellular proliferation. It is used to evaluate the proliferative potential of malignant tumors, since it is thought to stain only those cells undergoing active division. The paradoxical elevation of the Ki67 labeli...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Jennelle R,Gladson C,Palmer C,Guthrie B,Markert J

    更新日期:1999-01-01 00:00:00

  • Ultrasound-Guided DREZotomy: Technical Note.

    abstract::Dorsal root entry zone (DREZ) lesioning is still used as a choice of treatment for some painful conditions as well as spasticity in selected patients. The most commonly used techniques to perform DREZotomy are the microsurgical one and DREZ radiofrequency (RF) coagulation. The technical difficulties using punctures to...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Monaco BA,Lopes AJM,Teixeira MJ

    更新日期:2019-01-01 00:00:00

  • A comprehensive review of radiosurgery for cerebral arteriovenous malformations: outcomes, predictive factors, and grading scales.

    abstract::The management of cerebral arteriovenous malformations (AVMs) continues to present a challenge to neurosurgeons. The natural history of this condition, as well as the morbidity and mortality of therapeutic interventions, remains incompletely elucidated. Predictive factors and grading scales in AVM management allow ris...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章,评审


    authors: Starke RM,Komotar RJ,Hwang BY,Fischer LE,Otten ML,Merkow MB,Garrett MC,Isaacson SR,Connolly ES Jr

    更新日期:2008-01-01 00:00:00

  • Acoustic neurinomas with macrocysts treated with Gamma Knife radiosurgery.

    abstract::Six cases of acoustic neurinomas with macrocystic components are presented. In three cases the cystic portion was within the tumor, while in the other three, the cyst was peritumoral, in the form of a cul-de-sac within the arachnoid, in other words it was not a true tumor cyst. The six tumors are from a series of 74 a...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Pendl G,Ganz JC,Kitz K,Eustacchio S

    更新日期:1996-01-01 00:00:00

  • A prospective, randomized study of spinal cord stimulation versus reoperation for failed back surgery syndrome: initial results.

    abstract::Spinal cord stimulation (SCS) has been reported to be effective treatment for the failed back surgery syndrome in a number of retrospective case series. Its retrospectively reported results compare favorably with those of neurosurgical treatment alternatives, such as reoperation and ablative procedures. There has been...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: North RB,Kidd DH,Lee MS,Piantodosi S

    更新日期:1994-01-01 00:00:00

  • Neuropsychological outcome following pallidotomy and thalamotomy for Parkinson's disease.

    abstract::Cognitive and emotional outcomes were assessed after unilateral posteroventral pallidotomy (PVP) and ventral intermediate nucleus thalamotomy (Vim-Th) in patients suffering from idiopathic Parkinson's disease (PD). PVP was performed on 12 PD patients (8 men and 4 women, mean age 56.4 years, 6 left lesions and 6 right ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Fukuda M,Kameyama S,Yoshino M,Tanaka R,Narabayashi H

    更新日期:2000-01-01 00:00:00

  • Direct effect of subthalamic nucleus stimulation on levodopa-induced peak-dose dyskinesia in patients with Parkinson's disease.

    abstract::We examined the direct effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on levodopa-induced peak-dose dyskinesia in 45 patients with Parkinson's disease (PD) without reducing the levodopa dosage during the early period after surgery. In 8 patients (18%), the dyskinesia was quickly attenuated by bi...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Katayama Y,Oshima H,Kano T,Kobayashi K,Fukaya C,Yamamoto T

    更新日期:2006-01-01 00:00:00

  • On the origin of oscillopsia during pedunculopontine stimulation.

    abstract::We report a case of induced oscillopsia caused by deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN). Recent reports have described involuntary oscillopsia during DBS of the PPN that patients have described as trembling vision. Here we substantiate this observation using infra-red eye tracking. It has ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Jenkinson N,Brittain JS,Hicks SL,Kennard C,Aziz TZ

    更新日期:2012-01-01 00:00:00

  • The Origins of Human Functional Stereotaxis: A Reappraisal.

    abstract::In order to shed light on the first application of human functional stereotactic neurosurgery, whether it was in the realm of movement disorders, as has been claimed repeatedly, or in the realm of psychiatry, a review of the original scholarly literature was conducted. Tracking and scrutinising original publications b...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章,评审


    authors: Rzesnitzek L,Hariz M,Krauss JK

    更新日期:2019-01-01 00:00:00

  • Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.

    abstract::Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Yoshida M,Torigoe R,Ohtsuru K,Kuramoto S

    更新日期:1990-01-01 00:00:00

  • Selectivity of retrogasserian glycerol rhizotomy in the treatment of trigeminal neuralgia.

    abstract::The possibility of obtaining a selective effect on different trigeminal branches by glycerol rhizotomy was studied in the treatment of trigeminal neuralgia. Transcutaneous electrical stimulation was used to quantify sensory impairment. An attempt was made to direct the neurotoxic effect by maintaining the patient's he...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Bergenheim AT,Hariz MI,Laitinen LV

    更新日期:1991-01-01 00:00:00

  • A simple stereotactic method for frameless deep brain stimulation.

    abstract:BACKGROUND:Deep brain stimulation (DBS) is widely used to treat advanced Parkinson's disease, other movement and psychiatric disorders. DBS implantation requires application of a stereotactic frame throughout a lengthy procedure, making it uncomfortable and tiring. We designed a stereotactic cube to stage the operation...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Eljamel MS,Tulley M,Spillane K

    更新日期:2007-01-01 00:00:00

  • Functional recovery after combined cerebral and cerebellar hemispherectomy in the rat.

    abstract::The cerebellum seems to be one of the structures responsible for early neurological improvement after cerebral hemispherectomy and its consequent deficits. Considered as an accessory brain, the cerebellum may constitute a neurobiological substrate for the recovery of such extensive cortical and subcortical lesions. It...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Marino R Jr,Machado AG,Timo-Iaria C

    更新日期:2001-01-01 00:00:00

  • Changes in motor function induced by chronic motor cortex stimulation in post-stroke pain patients.

    abstract:BACKGROUND:In well-designed multicenter studies, the protocol of continuing motor cortex stimulation (MCS) temporarily for 3-6 weeks was employed with rehabilitation therapy, and these studies showed some recovery of motor weakness in post-stroke patients. OBJECTIVES:We aimed to clarify the effects of long-term MCS an...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Yamamoto T,Katayama Y,Watanabe M,Sumi K,Obuchi T,Kobayashi K,Oshima H,Fukaya C

    更新日期:2011-01-01 00:00:00

  • Deep brain stimulation for neuropathic pain.

    abstract::Paresthesia-producing (PP), but not periventricular grey (PVG) deep brain stimulation (DBS) proved effective in steady neuropathic pain in 25 patients receiving both, regardless of the PP site stimulated, but PVG-DBS suppressed allodynia or hyperpathia in 3 cases of stroke-induced pain. In patients with stroke-induced...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Tasker RR,Vilela Filho O

    更新日期:1995-01-01 00:00:00

  • Robot for CT-guided stereotactic neurosurgery.

    abstract::At the 1989 meeting of the World Society for Stereotactic and Functional Neurosurgery in Maebashi, the authors presented the concept and design of a stereotactic neurosurgical robot. The first prototype has now been completed and has entered clinical testing. The characteristics are as follows. The robot is positioned...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Fankhauser H,Glauser D,Flury P,Piguet Y,Epitaux M,Favre J,Meuli RA

    更新日期:1994-01-01 00:00:00