Abstract:
:Experimental studies indicate that deafferentation results in reorganization of the somatosensory map at various levels of the CNS, such that the representation of a body part adjacent to a region that is denervated expands into the deafferented area. Recent data suggest that in the human this occurs at the cortical level, but subcortical structures have not been systematically investigated. To test the hypothesis that the human thalamus is capable of significant reorganization as a result of changes in afferent input, microelectrode recording and stimulating techniques were used to define thalamic somatotopy in 61 patients undergoing stereotactic procedures. Five groups were compared: those with pain in the deafferented body part, face (n = 9), arm/hand (n = 4), leg/foot (n = 8) and hemibody (n = 5) and those with neither pain nor deafferentation, i.e., movement disorder (n = 24). Trunk representation, as determined from receptive fields, was significantly larger in patients with leg/foot deafferentation than in patients without deafferentation (1.8 +/- 0.7 vs. 0.5 +/- 0.2 mm; p < 0.01). Also, microstimulation induced paraesthesiae in the face from a significantly larger region of thalamus in the facially denervated group compared to the movement disorder group (13.8 +/- 2.8 vs. 3.7 +/- 0.6 mm; p < 0.001). There were no significant differences in the representation of other body parts in the five groups. The results in the leg-deafferented group agree with conclusions reached from animal studies; however, the human situation is more complex. There appear to be different patterns and degrees of somatotopic reorganization in the human, all of which may be associated with pain syndromes.
journal_name
Stereotact Funct Neurosurgjournal_title
Stereotactic and functional neurosurgeryauthors
Kiss ZH,Dostrovsky JO,Tasker RRdoi
10.1159/000098612subject
Has Abstractpub_date
1994-01-01 00:00:00pages
153-63issue
1-4eissn
1011-6125issn
1423-0372journal_volume
62pub_type
杂志文章abstract:BACKGROUND:Balloon compression of the gasserian ganglion has been a well-established percutaneous treatment of trigeminal neuralgia since the 1980s. However, puncture of the foramen ovale by conventional single-plane fluoroscopy can be difficult in cases of local anatomic abnormalities. CASE PRESENTATION:We present th...
journal_title:Stereotactic and functional neurosurgery
pub_type:
doi:10.1159/000509821
更新日期:2020-09-16 00:00:00
abstract:OBJECTIVE:Stereotactic biopsies are subject to sampling errors (essentially due to target selection). The presence of contrast enhancement is not a reliable marker of malignancy. The goal of the present study was to determine whether perfusion-weighted imaging can improve target selection in stereotactic biopsies. MET...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000338092
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To demonstrate that motor cortex stimulation (MCS) could improve motor function in patients with neuropathic pain. METHODS:In this prospective clinical study of 38 patients referred for MCS as treatment for their neuropathic pain, we collected any declaration of improvement in motor performance that could b...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章,随机对照试验
doi:10.1159/000338681
更新日期:2012-01-01 00:00:00
abstract::Although technological advances have reduced device-related complications, DBS surgery still carries a significant risk of transient and permanent complications. We report our experience in 86 patients and 149 DBS implants. Patients with Parkinson's disease, essential tremor and dystonia were treated. There were 8 per...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000064600
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:Gamma knife (GK) radiosurgery for trigeminal neuralgia (TN) has been effective in 50-80% of cases when using a single 4-mm collimator and a maximum dose of 60-90 Gy. Attempting to improve the response rate by increasing the dose may lead to increased risk of facial numbness or disturbed sensation. Combined use ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000076661
更新日期:2004-01-01 00:00:00
abstract::In this study, we investigated the efficacy of brachytherapy in the treatment of 138 patients with intracranial neoplasms of the CNS. Of the total number of patients, 50 presented with glioblastoma multiforme, 45 presented with low-grade glioma, 19 presented with anaplastic astrocytoma, 23 presented with metastases an...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000075100
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The optimum target in surgery for Parkinson's disease (PD) is still controversial, especially in patients with tremor-dominant PD. We aim to compare results in tremor-dominant patients undergoing pallidotomy vs. those undergoing simultaneous posteroventral pallidotomy (PVP) and ventral intermediate nucleus (...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000492229
更新日期:2018-01-01 00:00:00
abstract::Twenty-five gliomas of the cerebral hemisphere in children were examined. Most hemispheric gliomas in children have relatively clear margins and less infiltrative potential. Radiosurgery has a role in the treatment of these tumors in addition to reducing the risk of radiation injuries developing later. Fifteen patient...
journal_title:Stereotactic and functional neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1159/000099819
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Stereotactic postoperative imaging is essential for verification of the position of electrodes implanted for deep brain stimulation (DBS). MRI offers superior visualisation of the DBS targets relative to CT, but previous adverse incidents have heightened concerns about risks of postoperative MRI. Preope...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000225973
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Since a simple, rapid and accurate stereotactic system allowing CT monitoring would offer the neurosurgeon several advantages, the feasibility and application accuracy of frameless laser-guided freehand point stereotaxis for neurosurgical interventions was studied. METHODS:A Cartesian coordinate grid mounted...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000029649
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:During the placement of electrodes for deep brain stimulation (DBS), patients are commonly in a seated position, awake, and spontaneously breathing. Air may be entrained through bone or dural veins causing venous air emboli (VAE) and this phenomenon can result in significant hemodynamic changes. Althoug...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000177625
更新日期:2009-01-01 00:00:00
abstract::Current neuronavigational systems face two primary challenges: (1) automatic and robust registration between preoperative images and the operating room space, and (2) compensation for brain deformations that compromise the accuracy of the initial registration. To contend with these difficulties, we firstly estimate th...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000075171
更新日期:2003-01-01 00:00:00
abstract::Treatment of patients with nasopharyngeal carcinoma (NPC) using external beam radiation therapy (XRT) alone results in significant local recurrence. To improve local control, stereotactic radiosurgery (SRS) was used to boost radiation to the primary tumor site following XRT in 23 patients with NPC. SRS was delivered u...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000029753
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:This paper describes an Internet portal for stereotactic and functional neurosurgery with a probabilistic functional atlas (PFA) calculated from electrophysiological and neuroimaging data. This portal enables (1) data sharing among neurosurgeons; (2) the calculation of probabilistic functional maps of stereot...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000069499
更新日期:2002-01-01 00:00:00
abstract::Fractionated stereotactic radiotherapy is a method which attempts to combine the radiobiological advantages offered by dose fractionation with a technique for focal delivery of radiation. At McGill University, fractionated stereotactic radiotherapy is given with a linear accelerator-based dynamic stereotactic radiosur...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000098941
更新日期:1992-01-01 00:00:00
abstract::Dystonia secondary to cerebral infarcts presents months to years after the initial insult, is usually unilateral and causes significant morbidity. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is established as the most frequent target in the management of the dystonic symptoms. We report our expe...
journal_title:Stereotactic and functional neurosurgery
pub_type:
doi:10.1159/000509317
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Brain metastasis (BM) is the most common brain malignancy and a common cause of death in cancer patients. However, the relative outcome-related advantages and disadvantages of surgical resection (SR) and stereotactic radiosurgery (SRS) in the initial treatment of BM are controversial. METHOD:We systematical...
journal_title:Stereotactic and functional neurosurgery
pub_type: meta分析
doi:10.1159/000509319
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) implantation under general anesthesia (GA) is of great importance for patients with disabling off-medication symptoms or medical comorbidities. However, the relative advantages/disadvantages of routine local anesthesia (LA) surgery versus GA regarding clinical outcomes are contro...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000505079
更新日期:2019-01-01 00:00:00
abstract::Dorsal root entry zone (DREZ) lesions are effective in treating specific pain syndromes, most notably post-brachial plexus avulsion. There is limited experience, however, with lesions in the conus medullaris. We review the case of a patient having pelvic pain and urinary retention who failed to improve despite multipl...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000098920
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:We compared bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) with bilateral GPi DBS plus ventralis oralis (Vo) thalamotomy to analyze the effect of the combined Vo thalamotomy. METHODS:Between March 2003 and December 2008, 10 patients underwent DBS and/or Vo thalamotomy for treatment of ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000338093
更新日期:2012-01-01 00:00:00
abstract::Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100232
更新日期:1990-01-01 00:00:00
abstract::A 25-year-old woman with a large acoustic schwannoma underwent surgical excision 18 months after Gamma Knife radiosurgery because of transient expansion of the tumor causing ataxia. Histopathologial investigation by the TUNEL method revealed the presence of some apoptotic cells. The findings were compared with finding...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000056411
更新日期:1998-10-01 00:00:00
abstract:INTRODUCTION:The intersection of Bejjani's line with the well-delineated medial subthalamic nucleus (STN) border on MRI has recently been proposed as an individualized reference in subthalamic deep brain stimulation (DBS) surgery for Parkinson's disease (PD). We, therefore, aimed to investigate the applicability across...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000510802
更新日期:2020-11-18 00:00:00
abstract::Computed tomographic (CT), magnetic resonance (MR), MR angiographic and angiographic images, obtained after complete nidus obliteration had been angiographically confirmed, were reviewed in 9 patients who had undergone Gamma Knife treatment for cerebral arteriovenous malformations (AVMs). The period between angiograph...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000098772
更新日期:1995-01-01 00:00:00
abstract::Stereotactic operations have long been used to relieve agitation and muscle rigidity in Parkinson disease. Because of its high-density resolution, CT is quite effective to portray the location, size, shape and density of the thermocoagulative focus. The foci were classified into different types according to their chan...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000098740
更新日期:1995-01-01 00:00:00
abstract::During percutaneous microcompression of the gasserian ganglion for the relief of trigeminal neuralgia, a computerized technique for monitoring the pressure inside Meckel's cave was employed in 22 patients. A dedicated transducer connected to a computer records the balloon inflation pressure. Its variations are discern...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000099391
更新日期:1991-01-01 00:00:00
abstract::We reviewed the initial experience with 331 consecutive patients treated during the first 2 years of operation of the University of Pittsburgh Gamma Unit. Among 178 patients with vascular malformations, 161 had angiographically demonstrable arteriovenous malformations, and 17 had angiographically occult malformations....
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000100269
更新日期:1990-01-01 00:00:00
abstract::The correct explanation of the term 'stereotaxy' is linguistically not self-evident because the Greek term stereon means not spatial but 'hard' or 'solid'. The aim of our study was to clarify the term stereotaxy historically and linguistically. We carried out our study by reviewing the neurosurgical and ancient Greek ...
journal_title:Stereotactic and functional neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1159/000366490
更新日期:2015-01-01 00:00:00
abstract::Six patients with brain tumors within or near the primary motor cortex underwent preoperative functional magnetic resonance imaging (fMRI) and intraoperative cortical mapping, and the accuracy of those techniques for localization of the primary motor cortex and motor function beside the tumor were determined by compar...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:10.1159/000088160
更新日期:2005-01-01 00:00:00
abstract::Resection of epileptogenic lesions and pathological studies were performed in all 35 patients with temporal lobe epilepsy, 20 male and 15 female. Their ages ranged from 6 to 48 years with an average of 22 years. Various examinations including CT scan were carried out without any positive finding. EEG showed spike form...
journal_title:Stereotactic and functional neurosurgery
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00