Posttraumatic stress disorder: neurocircuitry and implications for potential deep brain stimulation.

Abstract:

:Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% of patients are still symptomatic 10 years after initial diagnosis. Recent advances in imaging have implicated changes in the limbic and autonomic corticostriatopallidothalamocortical (CSPTC) circuitry in the pathogenesis of this disease. Deep brain stimulation modulates CSPTC circuits in movement and other neuropsychiatric disorders. In this review, we discuss the salient clinical features and neurocircuitry of PTSD and propose a neuromodulation strategy for the disorder.

authors

Taghva A,Oluigbo C,Corrigan J,Rezai AR

doi

10.1159/000343148

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

207-19

issue

4

eissn

1011-6125

issn

1423-0372

pii

000343148

journal_volume

91

pub_type

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