Gamma knife radiosurgery for growth hormone-secreting pituitary adenomas invading the cavernous sinus.

Abstract:

:The authors assessed whether gamma knife radiosurgery is effective for patients with acromegaly where the pituitary tumors invaded the cavernous sinus. Radiosurgery was performed on 9 patients (average of 20 Gy to the tumor margin), 8 of whom had already undergone transsphenoidal surgery and/or craniotomy with occasional medication of octreotide to reduce tumor size as well as hormonal levels. All tumors have been well controlled so far with follow-up periods ranging from 12 to 69 months (mean: 42). No complications occurred. Forty percent of the patients showed hormonal normalization at 2 years, with the median being 31 months. Similarly, 50% of the patients demonstrated normalization of GH and IGF-I at 36 months. We conclude that gamma knife radiosurgery is a safe and effective tool to treat these tumors invading the cavernous sinus.

authors

Fukuoka S,Ito T,Takanashi M,Hojo A,Nakamura H

doi

10.1159/000066721

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

213-7

issue

3-4

eissn

1011-6125

issn

1423-0372

pii

66721

journal_volume

76

pub_type

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