Abstract:
:The interaction between DNA and different types of amino acid-based cationic surfactants was investigated. Particular attention was directed to determine the extent of influence of surfactant head-group geometry toward tuning the interaction behavior of these surfactants with DNA. An overview is obtained by gel retardation assay, isothermal titration calorimetry, fluorescence spectroscopy, and circular dichroism at different mole ratios of surfactant/DNA; also, cell viability was assessed. The studies show that the surfactants with more complex/bulkier hydrophobic head group interact more strongly with DNA but exclude ethidium bromide less efficiently; thus, the accessibility of DNA to small molecules is preserved to a certain extent. The presence of more hydrophobic groups surrounding the positive amino charge also gave rise to a significantly lower cytotoxicity. The surfactant self-assembly pattern is quite different without and with DNA, illustrating the roles of electrostatic and steric effects in determining the effective shape of a surfactant molecule.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Jadhav V,Maiti S,Dasgupta A,Das PK,Dias RS,Miguel MG,Lindman Bdoi
10.1021/bm8000765subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1852-9issue
7eissn
1525-7797issn
1526-4602journal_volume
9pub_type
杂志文章abstract::The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology, and engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of their versatility and the resulting prop...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/acs.biomac.7b00764
更新日期:2017-11-13 00:00:00
abstract::Cationic kraft lignin (CKL) macromolecules were produced via polymerizing kraft lignin (KL) with [2-(acryloyloxy)ethyl]trimethylammonium chloride (ATAC) or [2-(methacryloyloxy)ethyl]trimethylammonium methyl sulfate (METAM). Despite slightly different charge densities (2.3-2.5 mmol/g) of CKL, lignin-METAM (KL-METAM) ha...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01016
更新日期:2019-10-14 00:00:00
abstract::Neutron reflectometry was used to investigate the time-dependent beta-casein adsorption at the silica-aqueous solution interface. The transient and steady-state structural characteristics of the adsorbed layer were determined from reflectivity curves, fitted to three-layer and two-layer models. The results show that t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0155221
更新日期:2001-10-01 00:00:00
abstract::The viscous mucus coating that adheres to the epithelial surfaces of mammalian organs provides protection for the underlying tissues and is an efficient barrier to drug delivery. Pulsed-gradient spin-echo NMR and small-angle neutron scattering have been used to study the aqueous solution interaction of various model p...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9009667
更新日期:2010-01-11 00:00:00
abstract::As a means to stimulate wound healing, a hollow fiber membrane system might be placed within a wound bed to provide local and externally regulated controlled delivery of regenerative factors. After sufficient healing, it would be desirable to triggerably degrade these fibers as opposed to pulling them out. Accordingly...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500552f
更新日期:2014-08-11 00:00:00
abstract::New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weakly basic block, polyimidazole-hexyl methacrylate (poly-ImHeMA), which...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00286
更新日期:2015-07-13 00:00:00
abstract::Turbidimetric titration was used to initiate associative intermolecular interactions between a pair of protein molecules, gelatin-A and gelatin-B, having complementary charges that led to pH-induced liquid-liquid phase separation and the formation of complex coacervate. The stoichiometric binding ratio was found to be...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801160s
更新日期:2009-01-12 00:00:00
abstract::Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300173x
更新日期:2012-04-09 00:00:00
abstract::There is a distinct need for antimicrobial compounds that can act at surfaces without leaching into the environment. Such materials should be easy to synthesize, be easy to apply to surfaces, and display reasonable levels of antimicrobial and antifungal activity. Here we describe such a surface-active compound and dem...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060476w
更新日期:2006-10-01 00:00:00
abstract::Mechanically fibrillated cellulose nanofibrils (CNFs) have attracted special attention as building blocks for the development of advanced materials and composites. A correlation exists between CNF morphology and the properties of the materials they form. However, this correlation is often evaluated indirectly by proce...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00432
更新日期:2019-07-08 00:00:00
abstract::The ability of small interfering RNA (siRNA) to efficiently silence the expression of specific genes provides the basis for exciting new therapies based on RNA interference (RNAi). The efficient intracellular delivery of siRNA from cell uptake through the endosomal trafficking pathways into the cytoplasm remains a sig...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100652w
更新日期:2010-11-08 00:00:00
abstract::Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order to be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from the intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). I...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01024
更新日期:2019-10-14 00:00:00
abstract::We describe investigations of insulin release from thermoresponsive microgels using variable temperature (1)H NMR. Microgel particles composed of poly(N-isopropylacrylamide) were loaded with the peptide via a swelling technique, and this method was compared to simple equilibrium partitioning. Variable temperature (1)H...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060718s
更新日期:2006-10-01 00:00:00
abstract::Regenerated silk fibroin (RSF) fibers were obtained by extruding a concentrated aqueous silk fibroin solution into an ammonium sulfate coagulation bath. A custom-made simplified industrial-type wet-spinning device with continuous mechanical postdraw was used. The effect of dope concentration, coagulation bath, extrusi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900840h
更新日期:2010-01-11 00:00:00
abstract::Enzymatic ring-opening copolymerization of 5-benzyloxy-trimethylene carbonate (BTMC) and 1,4-dioxan-2-one (DON) was investigated for the first time. Immobilized porcine pancreas lipase (IPPL) on silica particles was selected to perform the copolymerization. A series of novel biodegradable copolymers with different com...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060070j
更新日期:2006-08-01 00:00:00
abstract::Since their discovery at the end of the previous millennium, carbon nanotubes (CNTs) have been the object of thousands of papers describing their applications in fields ranging from physics to electronics, photonics, chemistry, biology, and medicine. The development of chemical approaches to modify their graphitic sid...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/bm201020h
更新日期:2011-10-10 00:00:00
abstract::Ozonolysis of methyl soyate (biodiesel) was conducted in the presence of methanol, dichloromethane (solvent), and triethylamine (catalyst) at -75 degrees C. Structural analysis, including FTIR, GC, and GC-MS, showed that the total amount of double bonds in the mixture was reduced by more than 90% after 2 h of ozonolys...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049397f
更新日期:2005-05-01 00:00:00
abstract::Photodynamic therapy (PDT) has attracted widespread attention in recent years as a noninvasive and highly selective approach for cancer treatment. We have previously reported a significant increase in the 90-day complete response rate when tumor-bearing mice are treated with the epidermal growth factor receptor (EGFR)...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00274
更新日期:2017-06-12 00:00:00
abstract::Tissue engineering approaches for peripheral nerve regeneration employ biodegradable scaffolds coupled with growth factors for improved performance in regeneration of large nerve injuries. Electrospun nanofibers provide a versatile platform for fabrication of scaffolds with extracellular matrix like architecture and i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8012499
更新日期:2009-05-11 00:00:00
abstract::The structure of the Ca--alginate junction zones was investigated with X-ray scattering on gels prepared with different methods. Fiber diffraction reveals the popular egg-box model may not be the only possible structure for the junction zones. The (001) reflection, which should be extinguished due to 2/1 helical confo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060550a
更新日期:2007-02-01 00:00:00
abstract::Starches from WT, lam, and r pea mutants differing in amylopectin/amylose contents (70, 90, and 28% amylopectin, respectively) were used in kinetic studies of pancreatic α-amylase action at 37 °C and for investigations of their supramolecular structure and physicochemical properties during heating. For WT and lam star...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101070r
更新日期:2011-01-10 00:00:00
abstract::Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers from significant safety and supply issues. Herein, we describe the preparation of heparin mimetic homo- and copolymers via the reversible addition-fragmentation chain transfer (RAFT) ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01688
更新日期:2020-02-10 00:00:00
abstract::Escherichia coli serogroup O5 comprises two different subgroups (O5ab and O5ac), which are indiscernible from the point of view of standard immunological serotyping. The structural similarities between the O-antigen polysaccharides (PSs) of these two strains are remarkable, with the only difference being the glycosidi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400354y
更新日期:2013-07-08 00:00:00
abstract::Lignin-carbohydrate complexes (LCCs) were prepared in quantitative yield from spruce wood and from the corresponding kraft and oxygen-delignified pulps and were separated into different fractions on the basis of their carbohydrate composition. To obtain an understanding of the differences in lignin structure and react...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm058014q
更新日期:2005-11-01 00:00:00
abstract::Biological composites are typically based on an adhesive matrix that interlocks rigid reinforcing elements in fiber composite or brick-and-mortar assemblies. In nature, the adhesive matrix is often made up of proteins, which are also interesting model systems, as they are unique among polymers in that we know how to e...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm501514w
更新日期:2015-01-12 00:00:00
abstract::We investigated the rheological properties and the penetration of differently sized carboxylated nanoparticles in pig pulmonary mucus, on different distance and time scales. Nanoparticles were either mechanically mixed into the mucus samples or deposited as an aerosol, the latter resembling a more physiologically rele...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00164
更新日期:2016-04-11 00:00:00
abstract::Poly(lactic acid) (PLA) copolymers having a significantly higher glass transition temperature (T(g)) than that of high molar mass PLA homopolymers (typically 60 +/- 5 degrees C) were prepared. Lactic acid was copolymerized with 1,4:3,6-dianhydro-D-glucitol (isosorbide, ISB) and succinic acid (SA-2), 1,2,3,4-butanetetr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901338n
更新日期:2010-05-10 00:00:00
abstract::Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG and hyaluronan, is co...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300671s
更新日期:2012-08-13 00:00:00
abstract::To devise a sensitive cellulase assay based on substrates having most of the physical characteristics of native cellulose, 5-(4,6-dichlorotriazinyl)aminofluorescein (DTAF) was used as a grafting agent to prepare suspensions of fluorescent microfibrils from bacterial cellulose. These suspensions were digested by a seri...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020076i
更新日期:2003-05-01 00:00:00
abstract::Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701143g
更新日期:2008-06-01 00:00:00