Abstract:
:Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Szodoray P,Nakken B,Gaal J,Jonsson R,Szegedi A,Zold E,Szegedi G,Brun JG,Gesztelyi R,Zeher M,Bodolay Edoi
10.1111/j.1365-3083.2008.02127.xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
261-9issue
3eissn
0300-9475issn
1365-3083pii
SJI2127journal_volume
68pub_type
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