Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.

abstract：:Mosquito repellency data on acylpiperidines derived from the U.S. Department of Agriculture archives were modeled by using molecular descriptors calculated by CODESSA PRO software. An artificial neural network model was developed for the correlation of these archival results and used to predict the repellent activity ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katritzky AR,Wang Z,Slavov S,Tsikolia M,Dobchev D,Akhmedov NG,Hall CD,Bernier UR,Clark GG,Linthicum KJ

更新日期：2008-05-27 00:00:00

abstract：:Tetracycline resistance encoded by four genetically different determinants residing on plasmids in Escherichia coli was shown to be associated in each case with an energy-dependent decrease in accumulation of the antibiotic in whole cells in which resistance had been induced. The different class determinants examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMurry L,Petrucci RE Jr,Levy SB

更新日期：1980-07-01 00:00:00

abstract：:The genes coding for apolipoproteins (apo) AI, CIII, and AIV, designated APOA1, APOC3, and APOA4, respectively, are closely linked and tandemly organized in the long arm of the human chromosome 11. A DNA rearrangement involving the genes encoding apoAI and apoCIII in certain patients with premature atherosclerosis has...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karathanasis SK,Ferris E,Haddad IA

更新日期：1987-10-01 00:00:00

abstract：:Prion disease is characterized by the alpha-->beta structural conversion of the cellular prion protein (PrP(C)) into the misfolded and aggregated "scrapie" (PrP(Sc)) isoform. It has been speculated that methionine (Met) oxidation in PrP(C) may have a special role in this process, but has not been detailed and assigned...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolschner C,Giese A,Kretzschmar HA,Huber R,Moroder L,Budisa N

更新日期：2009-05-12 00:00:00

abstract：:Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimentary charcoal accumulation rates to construct long-term variations in fire during the past 3,000 y in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marlon JR,Bartlein PJ,Gavin DG,Long CJ,Anderson RS,Briles CE,Brown KJ,Colombaroli D,Hallett DJ,Power MJ,Scharf EA,Walsh MK

更新日期：2012-02-28 00:00:00

abstract：:Temporal dynamics of urban warming have been extensively studied at the diurnal scale, but the impact of background climate on the observed seasonality of surface urban heat islands (SUHIs) remains largely unexplored. On seasonal time scales, the intensity of urban-rural surface temperature differences ([Formula: see ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manoli G,Fatichi S,Bou-Zeid E,Katul GG

更新日期：2020-03-31 00:00:00

abstract：:Combined intracellular and microfluorometric recording techniques were used to evaluate whether the inhibition by cholinergic or adrenergic transmitters of the Ca2(+)-activated potassium current (IAHP) in hippocampal CA3 pyramidal cells was mediated by an alteration of depolarization-induced change in cytosolic free C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knöpfel T,Vranesic I,Gähwiler BH,Brown DA

更新日期：1990-06-01 00:00:00

abstract：:We have measured the angle-resolved transverse resistivity (ARTR), a sensitive indicator of electronic anisotropy, in high-quality thin films of the unconventional superconductor Sr2RuO4 grown on various substrates. The ARTR signal, heralding the electronic nematicity or a large nematic susceptibility, is present and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Nair HP,Bollinger AT,He X,Robinson I,Schreiber NJ,Shen KM,Schlom DG,Božović I

更新日期：2020-05-19 00:00:00

abstract：:Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been described as independent predictors of disease outcome. We further explore these findings by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basudhar D,Glynn SA,Greer M,Somasundaram V,No JH,Scheiblin DA,Garrido P,Heinz WF,Ryan AE,Weiss JM,Cheng RYS,Ridnour LA,Lockett SJ,McVicar DW,Ambs S,Wink DA

更新日期：2017-12-05 00:00:00

abstract：:Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable prec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY

更新日期：2020-03-17 00:00:00

abstract：:Blood cells transplantation is largely replacing bone marrow transplantation because engraftment is more rapid. This accelerated engraftment is thought to be mediated by relatively mature committed hematopoietic progenitor cells. Herein, we have used a modified rhodamine (Rho) staining procedure to identify and purify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zijlmans JM,Visser JW,Laterveer L,Kleiverda K,Heemskerk DP,Kluin PM,Willemze R,Fibbe WE

更新日期：1998-01-20 00:00:00

abstract：:The bacteriophage T4-encoded RegB endoribonuclease is produced during the early stage of phage development and targets mostly (but not exclusively) the Shine-Dalgarno sequences of early genes. In this work, we show that the degradation of RegB-cleaved mRNAs depends on a functional T4 polynucleotide kinase/phosphatase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durand S,Richard G,Bontems F,Uzan M

更新日期：2012-05-01 00:00:00

abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal S,Temsamani J,Tang JY

更新日期：1991-09-01 00:00:00

abstract：:We report the discovery in Lake Cuitzeo in central Mexico of a black, carbon-rich, lacustrine layer, containing nanodiamonds, microspherules, and other unusual materials that date to the early Younger Dryas and are interpreted to result from an extraterrestrial impact. These proxies were found in a 27-m-long core as p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Israde-Alcántara I,Bischoff JL,Domínguez-Vázquez G,Li HC,DeCarli PS,Bunch TE,Wittke JH,Weaver JC,Firestone RB,West A,Kennett JP,Mercer C,Xie S,Richman EK,Kinzie CR,Wolbach WS

更新日期：2012-03-27 00:00:00

abstract：:Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization to stress granules u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boncella AE,Shattuck JE,Cascarina SM,Paul KR,Baer MH,Fomicheva A,Lamb AK,Ross ED

更新日期：2020-03-17 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI 3-kinases) have been implicated in membrane trafficking in the secretory and endocytic pathways of yeast and mammalian cells, but the molecular mechanisms by which these lipid kinases operate are not known. Here we identify a protein of 170 kDa that is rapidly released from cell memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patki V,Virbasius J,Lane WS,Toh BH,Shpetner HS,Corvera S

更新日期：1997-07-08 00:00:00

abstract：:Molecular imaging probes have potential for in vivo identification of apoptosis and other intracellular processes. TcapQ, a cell-penetrating, near-infrared fluorescent peptide probe designed to be optically silent through intramolecular fluorescence quenching and activated by effector caspases, has been previously des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett EM,Zhang X,Maxwell D,Chang Q,Piwnica-Worms D

更新日期：2009-06-09 00:00:00

abstract：:Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly LM,Barila G,Liu P,Evdokimova VN,Trivedi S,Panebianco F,Gandhi M,Carty SE,Hodak SP,Luo J,Dacic S,Yu YP,Nikiforova MN,Ferris RL,Altschuler DL,Nikiforov YE

更新日期：2014-03-18 00:00:00

abstract：:Secondary organic aerosol (SOA) comprises a significant portion of atmospheric particular matter. The impact of particular matter on both human health and global climate has long been recognized. Despite its importance, there are still many unanswered questions regarding the formation and evolution of SOA in the atmos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WL,Griffin RJ,Dabdub D

更新日期：2010-04-13 00:00:00

abstract：:The glutathione S-transferases (GST) (glutathione transferase; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens. A cDNA clone containing the entire amino acid coding sequence of a human GST-2 subunit has been isolated using a lambda gt11 expression lib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Board PG,Webb GC

更新日期：1987-04-01 00:00:00

abstract：:By patch-clamp analysis, we have shown that chronic, intermittent mechanical strain (CMS) increases the activity of stretch-activated cation channels of osteoblast-like UMR-106.01 cells. CMS also produces a swelling-activated whole-cell conductance (Gm) regulated by varying strain levels. We questioned whether the swe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncan RL,Kizer N,Barry EL,Friedman PA,Hruska KA

更新日期：1996-03-05 00:00:00

abstract：:The primary structures of the tomato planta macho and tomato apical stunt viroids have been determined, and probable secondary structures are proposed. Both viroids can assume the rodlike conformation with extensive base-pairing characteristic of all known viroids. Sequence homologies between the two viroids (75%) and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiefer MC,Owens RA,Diener TO

更新日期：1983-10-01 00:00:00

abstract：:Based on transfection into cells in culture or natural transduction into retroviruses, proto-ras genes seem to derive transforming function either from heterologous promoters or from point mutations. Here we ask how such different events could achieve the same results. To identify homologous regulatory elements, about...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakraborty AK,Cichutek K,Duesberg PH

更新日期：1991-03-15 00:00:00

abstract：:Evolutionary processes leading to adaptive radiation regularly occur too fast to be accurately recorded in the fossil record but too slowly to be readily observed in living biota. The study of evolutionary radiations is thereby confronted with an epistemological gap between the timescales and approaches used by neonto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Bocxlaer B,Hunt G

更新日期：2013-08-20 00:00:00

abstract：:Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of sustaining a proliferative mutation. Here, we investigate whether the growth trajectory of clones can be better described by a model in which clone growth does not depe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chao DL,Eck JT,Brash DE,Maley CC,Luebeck EG

更新日期：2008-09-30 00:00:00

abstract：:In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, beta-arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NF-kappaB, IkappaBalpha, as a binding partn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witherow DS,Garrison TR,Miller WE,Lefkowitz RJ

更新日期：2004-06-08 00:00:00

abstract：:The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC development, where mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu B,Elinav E,Huber S,Strowig T,Hao L,Hafemann A,Jin C,Wunderlich C,Wunderlich T,Eisenbarth SC,Flavell RA

更新日期：2013-06-11 00:00:00

abstract：:Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Christiansen JR,Moreno JA,Kane SJ,Khaychuk V,Gallegos J,Kim S,Telling GC

更新日期：2019-06-18 00:00:00

abstract：:[3H]Puromycin and N-(ethyl-2-diazomalonyl)[3H]puromycin are incorporated into E. coli ribosomes on irradiation at 253.7 nm. Both compounds incorporate into both protein and nucleic acid. Two-dimensional gel electrophoresis of ribosomal protein shows that L23 is the major protein labeled by puromycin. Although incorpor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooperman BS,Jaynes EN,Brunswick DJ,Luddy MA

更新日期：1975-08-01 00:00:00

abstract：:Cellular transformation by the BCR/ABL oncogene depends on the ABL-encoded tyrosine kinase activity. To block BCR/ABL function, we created a unique tyrosine phosphatase by fusing the catalytic domain of SHP1 (SHP1c) to the ABL binding domain (ABD) of RIN1, an established binding partner and substrate for c-ABL and BCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lim YM,Wong S,Lau G,Witte ON,Colicelli J

更新日期：2000-10-24 00:00:00