Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis.


:Because of the increasing use of immunosuppressive and biological drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD). Consequently, improvement of healthcare workers' knowledge of this domain is urgent. In this review, the preventive measures that would help to reduce the rate of opportunistic infections in patients with IBD are listed, and the management of situations frequently confronting doctors is considered. In the absence of national and international recommendations, the information given here should help doctors to optimise patient outcomes.






Viget N,Vernier-Massouille G,Salmon-Ceron D,Yazdanpanah Y,Colombel JF




Has Abstract


2008-04-01 00:00:00
















  • Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells.

    abstract:BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...


    pub_type: 杂志文章


    authors: Medina F,Segundo C,Campos-Caro A,Salcedo I,García-Poley A,Brieva JA

    更新日期:2003-03-01 00:00:00

  • Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.

    abstract::Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture we...


    pub_type: 杂志文章


    authors: Bamford KB,Bickley J,Collins JS,Johnston BT,Potts S,Boston V,Owen RJ,Sloan JM

    更新日期:1993-10-01 00:00:00

  • Histamine and duodenal ulceration in renal transplant recipients.

    abstract::Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...


    pub_type: 杂志文章


    authors: Timoney AG,Man WK,Spencer J,Taylor H,Williams G

    更新日期:1989-01-01 00:00:00

  • Plasminogen fragment K1-5 improves survival in a murine hepatocellular carcinoma model.

    abstract:BACKGROUND:The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, and new alternative treatments are needed. AIMS:To comparatively test the angiostatic and antitumour effects of adenoviral gene transfer of angiostatin (PlgK1-4, amino acids 1-440) and full kringles 1-5 (PlgK1-5, amino acids 1-546) ...


    pub_type: 杂志文章


    authors: Schmitz V,Raskopf E,Gonzalez-Carmona MA,Vogt A,Rabe C,Leifeld L,Kornek M,Sauerbruch T,Caselmann WH

    更新日期:2007-02-01 00:00:00

  • Mucosal-associated bacterial flora of the intestine in patients with Crohn's disease and in a control group.

    abstract::The bacterial flora intimately associated with the intestinal mucosa of patients with Crohn's disease has been examined and compared with the mucosal flora of a control group. Specimens were obtained at operation from patients undergoing intestinal surgery. Whole thickness intestinal sections were taken from the disea...


    pub_type: 杂志文章


    authors: Peach S,Lock MR,Katz D,Todd IP,Tabaqchali S

    更新日期:1978-11-01 00:00:00

  • Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.

    abstract:BACKGROUND AND AIMS:Surgical management of extrahepatic cholestasis is frequently complicated by bacterial translocation and severe liver injury. The aim of this study was to clarify the involvement of Toll-like receptors (TLRs) in the pathogenesis of bacterial translocation and liver injury in obstructive cholestasis....


    pub_type: 杂志文章


    authors: Ogawa A,Tagawa T,Nishimura H,Yajima T,Abe T,Arai T,Taniguchi M,Takeda K,Akira S,Nimura Y,Yoshikai Y

    更新日期:2006-01-01 00:00:00

  • Cell loss from small intestinal mucosa: a morphological study.

    abstract::Large numbers of cells are shed from small intestinal mucosa but they are so rapidly destroyed that there is little direct information about their morphological types. Material obtained by washing the human and rat small intestine was immediately processed and examined by light and electron microscopy. Small intestina...


    pub_type: 杂志文章


    authors: Pink IJ,Croft DN,Creamer B

    更新日期:1970-03-01 00:00:00

  • Refractory pouchitis: does it reflect underlying Crohn's disease?

    abstract::Typical 'pouchitis' is a well recognised complication of ileal pouches in ulcerative colitis. Infrequently, a refractory pouchitis (RP) presents with certain clinical, endoscopic, and pathological features resembling Crohn's disease and is often ascribed to misdiagnosis of the initial colitis. To test that hypothesis ...


    pub_type: 杂志文章


    authors: Subramani K,Harpaz N,Bilotta J,Bodian C,Rubin PH,Janowitz HD,Gelernt IM,Sachar DB

    更新日期:1993-11-01 00:00:00

  • Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

    abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...


    pub_type: 杂志文章


    authors: Okugawa Y,Toiyama Y,Toden S,Mitoma H,Nagasaka T,Tanaka K,Inoue Y,Kusunoki M,Boland CR,Goel A

    更新日期:2017-01-01 00:00:00

  • Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera.

    abstract::Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain. 'Steady state' perfusions (10 ml/minute) in 12 patients with acute cholera, and repeat perfusions in nine of these patie...


    pub_type: 杂志文章


    authors: Van Loon FP,Rabbani GH,Bukhave K,Rask-Madsen J

    更新日期:1992-05-01 00:00:00

  • Campylobacter colitis: histological immunohistochemical and ultrastructural findings.

    abstract::The colonic biopsy specimens of 22 patients with colitis and positive stool cultures for Campylobacter jejuni were studied in order to obtain histological and immunohistochemical criteria to differentiate Campylobacter colitis from chronic inflammatory bowel disease. In addition we tried to identify Campylobacter incl...


    pub_type: 杂志文章


    authors: van Spreeuwel JP,Duursma GC,Meijer CJ,Bax R,Rosekrans PC,Lindeman J

    更新日期:1985-09-01 00:00:00

  • Predictors of variceal bleeding: an analysis of clinical, endoscopic, and haemodynamic variables, with special reference to intravariceal pressure.

    abstract::To assist in the prediction of variceal bleeding we examined 12 clinical, endoscopic and haemodynamic variables in 126 patients with portal hypertension (72 bleeders and 54 non-bleeders). Multiple regression and discriminant analysis were utilised for 101 patients. Stepwise regression among the 12 variables explained ...


    pub_type: 杂志文章


    authors: Sarin SK,Sundaram KR,Ahuja RK

    更新日期:1989-12-01 00:00:00

  • Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.

    abstract:BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...


    pub_type: 杂志文章


    authors: Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

    更新日期:2002-07-01 00:00:00

  • Solitary angiodysplastic lesions in the ileocaecal region diagnosed by angiography.

    abstract::Single angiodysplasias were demonstrated by preoperative angiography in four patients. In two cases the lesions were in the terminal ileum, and were situated just above the caecum in the other two patients. In three patients, contrast medium was extravasated into the bowel lumen. Histological verification was obtained...


    pub_type: 杂志文章


    authors: Whitehouse GH

    更新日期:1973-12-01 00:00:00

  • Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells.

    abstract:BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...


    pub_type: 杂志文章


    authors: Xing R,Li W,Cui J,Zhang J,Kang B,Wang Y,Wang Z,Liu S,Lu Y

    更新日期:2012-01-01 00:00:00

  • Long-term performance of colorectal cancerscreening programmes based on the faecal immunochemical test.

    abstract:BACKGROUND:The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear. METHODS:In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (...


    pub_type: 杂志文章


    authors: Zorzi M,Hassan C,Capodaglio G,Fedato C,Montaguti A,Turrin A,Rosano A,Monetti D,Stocco C,Baracco S,Russo F,Repici A,Rugge M

    更新日期:2018-12-01 00:00:00

  • Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity.

    abstract:OBJECTIVE:Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in the absence of coeliac disease (CD) and wheat allergy. No biomarkers are available to diagnose NCGS and the gold standard double-blind placebo-controlled gl...


    pub_type: 杂志文章


    authors: Barbaro MR,Cremon C,Morselli-Labate AM,Di Sabatino A,Giuffrida P,Corazza GR,Di Stefano M,Caio G,Latella G,Ciacci C,Fuschi D,Mastroroberto M,Bellacosa L,Stanghellini V,Volta U,Barbara G

    更新日期:2020-11-01 00:00:00

  • Cholic acid synthesis as an index of the severity of liver disease in man.

    abstract::Bile acid pool size and kinetics were determined in 17 patients with cirrhosis and 11 patients without liver disease and correlated with the severity of liver disease as determined by the usual clinical and laboratory criteria. In order to assess the severity of liver disease, a grading system was devised which assign...


    pub_type: 杂志文章


    authors: McCormick WC 3rd,Bell CC Jr,Swell L,Vlahcevic ZR

    更新日期:1973-11-01 00:00:00

  • Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp parvalbumin.

    abstract:BACKGROUND:Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism. AIMS:To characterise one of the most frequent IgE defined food allergens, fish parvalbumin. METHODS:Tissue and subcellular distribution of carp parvalbumin was analysed by i...


    pub_type: 杂志文章


    authors: Bugajska-Schretter A,Grote M,Vangelista L,Valent P,Sperr WR,Rumpold H,Pastore A,Reichelt R,Valenta R,Spitzauer S

    更新日期:2000-05-01 00:00:00

  • Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis.

    abstract::A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effect...


    pub_type: 杂志文章


    authors: Willoughby CP,Aronson JK,Agback H,Bodin NO,Truelove SC

    更新日期:1982-12-01 00:00:00

  • Oesophageal tone in patients with achalasia.

    abstract:BACKGROUND:The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. AIM:To quantify oesophageal tonic activity in healt...


    pub_type: 杂志文章


    authors: González M,Mearin F,Vasconez C,Armengol JR,Malagelada JR

    更新日期:1997-09-01 00:00:00

  • British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines.

    abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...


    pub_type: 杂志文章,实务指引


    authors: Rutter MD,East J,Rees CJ,Cripps N,Docherty J,Dolwani S,Kaye PV,Monahan KJ,Novelli MR,Plumb A,Saunders BP,Thomas-Gibson S,Tolan DJM,Whyte S,Bonnington S,Scope A,Wong R,Hibbert B,Marsh J,Moores B,Cross A,Sharp L

    更新日期:2020-02-01 00:00:00

  • Multiple and recurrent inflammatory fibroid polyps in a Devon family ('Devon polyposis syndrome'): an update.

    abstract::Inflammatory fibroid polyps are uncommon but well documented as solitary polyps occurring typically in the stomach or ileum. A Devon family has previously been reported in which a female in three successive generations has presented with multiple polyps requiring repeated surgery over a number of years. A further two ...


    pub_type: 杂志文章


    authors: Allibone RO,Nanson JK,Anthony PP

    更新日期:1992-07-01 00:00:00

  • Small intestinal structure and passive permeability in systemic sclerosis.

    abstract::Seventeen patients with proven systemic sclerosis had a peroral jejunal biopsy performed. Four biopsies were regarded as showing abnormalities, which were mostly confined to the deeper structures, although in two there was a minimal degree of villous atrophy without epithelial cell changes. Passive intestinal permeabi...


    pub_type: 杂志文章


    authors: Cobden I,Rothwell J,Axon AT,Dixon MF,Lintott DJ,Rowell NR

    更新日期:1980-04-01 00:00:00

  • Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells.

    abstract:OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...


    pub_type: 杂志文章


    authors: Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

    更新日期:2020-06-01 00:00:00

  • Palliative removal of a giant polypoid 'carcinosarcoma' of the oesophagus by YAG laser photocoagulation of the tumour stalk.

    abstract::Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...


    pub_type: 杂志文章


    authors: Richardson D,Wyatt JI,Miloszewski KJ

    更新日期:1992-08-01 00:00:00

  • Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium.

    abstract:BACKGROUND AND AIMS:Biliary lipid absorption by the gall bladder mucosa and the cholesterol content of the gall bladder wall appear to play a role in cholesterol gall stone formation. As the scavenger receptor class B type I (SR- BI) regulates cellular cholesterol uptake, we studied its expression in human and murine g...


    pub_type: 杂志文章


    authors: Miquel JF,Moreno M,Amigo L,Molina H,Mardones P,Wistuba II,Rigotti A

    更新日期:2003-07-01 00:00:00

  • Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats.

    abstract:BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...


    pub_type: 杂志文章


    authors: Rodríguez-Ortigosa CM,Cincu RN,Sanz S,Ruiz F,Quiroga J,Prieto J

    更新日期:2002-05-01 00:00:00

  • Sex hormones, and acid gastric secretion induced with carbachol, histamine, and gastrin.

    abstract::This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats...


    pub_type: 杂志文章


    authors: Amure BO,Omole AA

    更新日期:1970-08-01 00:00:00

  • Ranitidine increases the bioavailability of postprandial ethanol by the reduction of first pass metabolism.

    abstract::Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...


    pub_type: 临床试验,杂志文章


    authors: Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

    更新日期:1995-09-01 00:00:00