Abstract:
:Despite elegant behavioral descriptions of abnormalities for processing emotional facial expressions and biological motion in autism, identification of the neural mechanisms underlying these abnormalities remains a critical and largely unmet challenge. We compared brain activity with dynamic and static facial expressions in participants with and without high-functioning autism using event-related functional magnetic resonance imaging (fMRI) and three classes of face stimuli-emotion morphs (fearful and angry), identity morphs and static images (fearful, angry and neutral). We observed reduced activity in the amygdala (AMY) and fusiform gyrus (FFG) to dynamic emotional expressions in people with autism. There was also a lack of modulation by dynamic compared with static emotional expressions of social brain regions including the AMY, posterior superior temporal sulcus (STS) region and FFG. We observed equivalent emotion and identity morph-evoked activity in participants with and without autism in a region corresponding to the expected location of the more generally motion-sensitive area MT or V5. We conclude that dysfunctions in key components of the human face processing system including the AMY, FFG and posterior STS region are present in individuals with high-functioning autism, and this dysfunction might contribute to the deficits in processing emotional facial expressions.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Pelphrey KA,Morris JP,McCarthy G,Labar KSdoi
10.1093/scan/nsm010subject
Has Abstractpub_date
2007-06-01 00:00:00pages
140-9issue
2eissn
1749-5016issn
1749-5024journal_volume
2pub_type
杂志文章abstract::Individuals with autism spectrum disorders (ASD) have documented deficits in face processing, face memory and abnormal activation of the neural circuitry that supports these functions. To examine speed of processing of faces in ASD, high density event-related brain potentials were recorded to images of faces, inverted...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp002
更新日期:2012-06-01 00:00:00
abstract::Intranasal oxytocin (OT) has previously been found to increase spirituality, an effect moderated by OT-related genotypes. This pre-registered study sought to conceptually replicate and extend those findings. Using a single dose of intranasal OT vs placebo (PL), we investigated experimental treatment effects, and moder...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy068
更新日期:2018-09-11 00:00:00
abstract::Recent symptom provocation studies that compared patients suffering from dental phobia with healthy controls identified hyperactivation of basal ganglia structures, but none have assessed striatal functional connectivity. We reanalyzed data from a previous functional magnetic resonance imaging study on dental phobia. ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst150
更新日期:2014-10-01 00:00:00
abstract::Researchers, parents, and educators consistently observe a stark mismatch between biologically preferred and socially imposed sleep-wake hours in adolescents, fueling debate about high school start times. We contribute neural evidence to this debate with electroencephalogram (EEG) data collected from high school stude...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa142
更新日期:2020-10-17 00:00:00
abstract::Major depressive disorder (MDD) has been associated with abnormalities in cortical thickness and autonomic function. Adolescence is a time notable for brain development and MDD onset. In healthy adolescents, greater resting state vagal activity (RVA) is associated with lower cortical thickness. The relationship betwee...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy046
更新日期:2018-09-04 00:00:00
abstract::While a persuasion network has been proposed, little is known about how network connections between brain regions contribute to attitude change. Two possible mechanisms have been advanced. One hypothesis predicts that attitude change results from increased connectivity between structures implicated in affective and ex...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx126
更新日期:2017-12-01 00:00:00
abstract::The reduction of aversive emotions by a conspecific's presence-called social buffering-is a universal phenomenon in the mammalian world and a powerful form of human social emotion regulation. Animal and human studies on neural pathways underlying social buffering typically examined physiological reactions or regional ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa068
更新日期:2020-07-01 00:00:00
abstract::Despite gender is a salient feature in face recognition, the question of whether stereotyping modulates face processing remains unexplored. Event-related potentials from 40 participants (20 female) was recorded as male and female faces matched or mismatched previous gender-stereotyped statements and were compared with...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa117
更新日期:2020-11-06 00:00:00
abstract::An extensive body of research defines the default-mode network (DMN) to be one of the critical networks of the human brain, playing a pivotal functional role in processes of internal mentation. Alterations in the connectivity of this network as a function of aging have been found, with reductions associated with funct...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss115
更新日期:2013-01-01 00:00:00
abstract::A core design feature of human communication systems and expressive behaviours is their temporal organization. The cultural evolutionary origins of this feature remain unclear. Here, we test the hypothesis that regularities in the temporal organization of signalling sequences arise in the course of cultural transmissi...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy054
更新日期:2018-09-05 00:00:00
abstract::Simulation models of facial expressions propose that sensorimotor regions may increase the clarity of facial expressions representations in extrastriate areas. We monitored the event-related potential marker of visual working memory (VWM) representations, namely the sustained posterior contralateral negativity (SPCN),...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy095
更新日期:2018-12-04 00:00:00
abstract::Synchronous movement is a key component of social behaviour in several species including humans. Recent theories have suggested a link between interpersonal synchrony of brain oscillations and interpersonal movement synchrony. The present study investigated this link. Using transcranial alternating current stimulation...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsw172
更新日期:2017-01-24 00:00:00
abstract::Previous research has clearly documented that risky decision making is different in young and older adults. Yet, there has been a relative dearth of research that seeks to understand such age-related changes in the neural activities associated with risk taking. To address this research issue, 21 men (12 young men, mea...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsm033
更新日期:2008-03-01 00:00:00
abstract::Despite being one of the healthiest developmental periods, morbidity and mortality rates increase dramatically during adolescence, largely due to preventable, risky behaviors. Heightened reward sensitivity, coupled with ineffective cognitive control, has been proposed to underlie adolescents' risk taking. In this stud...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv026
更新日期:2015-10-01 00:00:00
abstract::Knowledge about interactions between reward and negative processing is rudimentary. Here, we employed functional MRI to probe how potential reward signaled by advance cues alters aversive distractor processing during perception. Behaviorally, the influence of aversive stimuli on task performance was reduced during the...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx067
更新日期:2017-09-01 00:00:00
abstract::Acute stress is associated with beneficial as well as detrimental effects on cognition in different individuals. However, it is not yet known how stress can have such opposing effects. Stroop-like tasks typically show this dissociation: stress diminishes speed, but improves accuracy. We investigated accuracy and speed...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1093/scan/nsx043
更新日期:2017-07-01 00:00:00
abstract::When subjects are required to reason about someone's false belief, a consistent pattern of brain regions are recruited including the medial prefrontal cortex, medial precuneus and bilateral temporo-parietal junction. Previous group analyses suggest that the two medial regions, but not the lateral regions, are also rec...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsl034
更新日期:2006-12-01 00:00:00
abstract::To study emotional reactions to music, it is important to consider the temporal dynamics of both affective responses and underlying brain activity. Here, we investigated emotions induced by music using functional magnetic resonance imaging (fMRI) with a data-driven approach based on intersubject correlations (ISC). Th...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv060
更新日期:2015-12-01 00:00:00
abstract::Meditation has been shown to improve creativity in some situation. However, little is known about the brain systems underling insight into a problem when the person fails to solve the problem. Here, we examined the neural correlation using Chinese Remote Association Test, as a measure of creativity. We provide a solut...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu032
更新日期:2015-01-01 00:00:00
abstract::Strong evidence links the 5-HTTLPR genotype to the modulation of amygdala reactivity during fear conditioning, which is considered to convey the increased vulnerability for anxiety disorders in s-allele carriers. In addition to amygdala reactivity, the 5-HTTLPR has been shown to be related to alterations in structural...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu108
更新日期:2015-05-01 00:00:00
abstract::High frequency repetitive Transcranial Magnetic Stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been found to alleviate depressive symptoms. However, the mechanisms driving these effects are still poorly understood. In the current study, we tested the idea that this intervention protects ag...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1093/scan/nsw180
更新日期:2017-04-01 00:00:00
abstract::Neuroimaging studies on moral decision-making have thus far largely focused on differences between moral judgments with opposing utilitarian (well-being maximizing) and deontological (duty-based) content. However, these studies have investigated moral dilemmas involving extreme situations, and did not control for two ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr005
更新日期:2012-04-01 00:00:00
abstract::Previous neuroimaging studies on empathy have not clearly identified neural systems that support the three components of empathy: affective congruence, perspective-taking, and prosocial motivation. These limitations stem from a focus on a single emotion per study, minimal variation in amount of social context provided...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss088
更新日期:2014-01-01 00:00:00
abstract::The recognition of threatening faces is important for making social judgments. For example, threatening facial features of defendants could affect the decisions of jurors during a trial. Previous neuroimaging studies using faces of members of the general public have identified a pivotal role of the amygdala in perceiv...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr085
更新日期:2013-02-01 00:00:00
abstract::Theoretically, normal developmental variation in amygdala volumes may be altered under conditions of severe stress. The purpose of this article was to examine whether posttraumatic stress moderates the association between age and amygdala volumes in youth exposed to traumatic events who are experiencing symptoms of po...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv053
更新日期:2015-12-01 00:00:00
abstract::Animal and human research indicates that the early environment can exert effects on hypothalamic pituitary adrenal (HPA) axis functioning across the lifespan. Using data from the National Study of Midlife Development in the United States and the National Study of Daily Experience substudy, we identified curvilinear re...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq037
更新日期:2011-04-01 00:00:00
abstract::The subjective and behavioral effects of intracranial electrical stimulation (iES) have been studied for decades, but there is a knowledge gap regarding the relationship between the magnitude of electric current and the type, intensity and valence of evoked subjective experiences. We report on rare iES data from 18 ne...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz015
更新日期:2019-05-17 00:00:00
abstract::Previous research has suggested that perceivers spontaneously extract trait-specific information from the behaviour of others. However, little is known about whether perceivers spontaneously engage in the same depth of social-cognitive processing for all person information or reserve such processing specifically for i...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsl007
更新日期:2006-06-01 00:00:00
abstract::The transition from childhood to adolescence is marked by increasingly sophisticated social cognitive abilities that are paralleled by significant functional maturation of the brain. However, the role of social and neurobiological development in facilitating age differences in prosocial behavior remains unclear. Using...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy117
更新日期:2019-02-13 00:00:00
abstract::We investigated how visual and linguistic information interact in the perception of emotion. We borrowed a phenomenon from film theory which states that presentation of an as such neutral visual scene intensifies the percept of fear or suspense induced by a different channel of information, such as language. Our main ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq050
更新日期:2011-09-01 00:00:00