CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry.

Abstract:

:The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure. The program is freely available at http://www.pu.kielce.pl/ibiol/cabas.

journal_name

Radiat Prot Dosimetry

authors

Deperas J,Szluinska M,Deperas-Kaminska M,Edwards A,Lloyd D,Lindholm C,Romm H,Roy L,Moss R,Morand J,Wojcik A

doi

10.1093/rpd/ncm137

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

115-23

issue

2

eissn

0144-8420

issn

1742-3406

pii

124/2/115

journal_volume

124

pub_type

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