The genetics of radiation-induced osteosarcoma.

Abstract:

:Individual genetic variation can influence susceptibility to the carcinogenic effects of many environmental carcinogens. In radiation-exposed populations those individuals with a greater genetically determined susceptibility would be at greater risk of developing cancer. To include this modification of risk into radiation protection schemes it is necessary to identify the genes responsible for determining individual sensitivity. Alpha-particle-induced osteosarcoma in the mouse has been adopted as a model of human radiation carcinogenesis, and genome-wide screens have been conducted for allelic imbalance and genetic linkage. These studies have revealed a series of genes involved in determining the sensitivity to radiogenic osteosarcoma formation.

journal_name

Radiat Prot Dosimetry

authors

Rosemann M,Kuosaite V,Nathrath M,Atkinson MJ

doi

10.1093/oxfordjournals.rpd.a006778

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

257-9

issue

1-4

eissn

0144-8420

issn

1742-3406

journal_volume

99

pub_type

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