Fish on Prozac: a simple, noninvasive physiology laboratory investigating the mechanisms of aggressive behavior in Betta splendens.

Abstract:

:The neuromodulator serotonin is an important regulator of aggressive behavior in vertebrates. Experimentally increasing synaptic levels of serotonin with fluoxetine, a selective serotonin reuptake inhibitor, has been shown to reliably decrease the expression of aggressive behavior. Here, we describe a method by which fluoxetine can be noninvasively administered to male Betta splendens (an attractive model for the study of aggressive behavior) and describe a simple laboratory exercise that allows students to experimentally investigate the physiological mechanisms of aggressive behavior. We demonstrate that relatively short-term exposure (3 h) of male bettas to as little as 3 microg/ml of fluoxetine-treated aquarium water is sufficient to reduce the expression of specific aggressive behaviors. We emphasize the physiological concepts that can be addressed with this exercise, including the role of the serotonergic system in regulating aggression, and the interplay of environmental contaminants and physiology in regulating the expression of behavior. We also highlight important aspects of experimental design. This exercise can be flexibly altered to accommodate one or several laboratory periods. It is also low cost, is low impact to the animals, and requires minimal preparation time for instructors.

journal_name

Adv Physiol Educ

authors

Lynn SE,Egar JM,Walker BG,Sperry TS,Ramenofsky M

doi

10.1152/advan.00024.2007

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

358-63

issue

4

eissn

1043-4046

issn

1522-1229

pii

31/4/358

journal_volume

31

pub_type

杂志文章
  • Students' perceived value of physiology course activities in a Sudanese medical faculty.

    abstract::The physiology course in our department consists of lectures, laboratory sessions, and tutorials, all of which are teacher centered, as well as student-led seminars. The overall aim of this project was to investigate student perceptions of the value of varying academic activities on their learning of physiology. A fac...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00070.2012

    authors: Kaddam L,Elnimeiri MK

    更新日期:2012-12-01 00:00:00

  • How to review a paper.

    abstract::Most scientists acquire their training in manuscript review not through instruction but by actually doing it. Formal training in manuscript analysis is rarely, if ever, provided. Editors usually choose reviewers because of expertise in a given subject area and availability. If an individual repeatedly submits bad revi...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00057.2002

    authors: Benos DJ,Kirk KL,Hall JE

    更新日期:2003-12-01 00:00:00

  • Learning style preferences and course performance in an undergraduate physiology class.

    abstract::Learning styles may be classified according to the sensory modality that one most prefers to use when internalizing information. The four major sensory modalities are visual, aural or auditory, read/write, and kinesthetic. The purpose of this study was to investigate the relationship between preferred learning style, ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00048.2009

    authors: Dobson JL

    更新日期:2009-12-01 00:00:00

  • Using the pathophysiology of obstructive sleep apnea to teach cardiopulmonary integration.

    abstract::Obstructive sleep apnea (OSA) is a common disorder of upper airway obstruction during sleep. The effects of intermittent upper airway obstruction include alveolar hypoventilation, altered arterial blood gases and acid-base status, and stimulation of the arterial chemoreceptors, which leads to frequent arousals. These ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.90137.2008

    authors: Levitzky MG

    更新日期:2008-09-01 00:00:00

  • Structure-function relations in physiology education: Where's the mechanism?

    abstract::Physiology demands systems thinking: reasoning within and between levels of biological organization and across different organ systems. Many physiological mechanisms explain how structures and their properties interact at one level of organization to produce emergent functions at a higher level of organization. Curren...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00175.2016

    authors: Lira ME,Gardner SM

    更新日期:2017-06-01 00:00:00

  • Making students do the thinking: team-based learning in a laboratory course.

    abstract::Team-based learning (TBL) is a teaching pedagogy for flipping the classroom that moves the focus of the classroom from the instructor conveying course concepts via lecture to the application of concepts by student teams. It has been used extensively in lecture courses; however, there is little evidence of its use in l...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00108.2013

    authors: Simonson SR

    更新日期:2014-03-01 00:00:00

  • The effects of discovery learning in a lower-division biology course.

    abstract::This study investigated discovery learning pedagogy and its effects on students' achievement and attitudes toward instruction in a lower-division biology course, entitled Structure and Function of Organisms. Instruction was primarily lecture-based but included four discovery learning activities. Results indicate that ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advances.2001.25.2.62

    authors: Wilke RR,Straits WJ

    更新日期:2001-12-01 00:00:00

  • The flipped classroom allows for more class time devoted to critical thinking.

    abstract::The flipped classroom was utilized in a two-semester, high-content science course that enrolled between 50 and 80 students at a small liberal arts college. With the flipped model, students watched ~20-min lectures 2 days/wk outside of class. These videos were recorded via screen capture and included a detailed note ou...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00033.2016

    authors: DeRuisseau LR

    更新日期:2016-12-01 00:00:00

  • Using a classic paper by Robin Fahraeus and Torsten Lindqvist to teach basic hemorheology.

    abstract::"The viscosity of the blood in narrow capillary tubes" by Robin Fåhraeus and Torsten Lindqvist (Am J Physiol 96: 562-568, 1931) can be a valuable opportunity for teaching basic hemorheological principles in undergraduate cardiovascular physiology. This classic paper demonstrates that a progressive decline in apparent ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00009.2013

    authors: Toksvang LN,Berg RM

    更新日期:2013-06-01 00:00:00

  • Cardiovascular and pulmonary interactions: why Galen's misconceptions proved clinically useful for 1,300 years.

    abstract::The new generations of physicians are, to a large extent, unaware of the complex philosophical and biological concepts that created the bases of modern medicine. Building on the Hellenistic tradition of the four humors and their qualities, Galen (AD 129 to c. 216) provided a persuasive scheme of the structure and func...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00058.2020

    authors: Neder JA

    更新日期:2020-06-01 00:00:00

  • Emergency contraception and RU-486 (mifepristone): do bioethical discussions improve learning and retention?

    abstract::To systematically investigate whether the inclusion of a bioethical discussion improves the learning and retention of biological content, students in two sections of an introductory zoology class were taught the biology behind emergency contraception and RU-486. Students in one section of the course participated in a ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00122.2011

    authors: Bodensteiner KJ

    更新日期:2012-03-01 00:00:00

  • Adaptive strategies to conduct participant-centric structured virtual group discussions for postgraduate students in the wake of the COVID-19 pandemic.

    abstract::In the wake of COVID-19, the postgraduate activities in physiology were shifted from live (face-to-face teaching) to virtual mode. This transition posed a challenge to postgraduate students and faculty moderators, especially for participant-centric group discussion, wherein face-to-face interaction contributes signifi...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00136.2020

    authors: Kaur S,Bir M,Chandran DS,Deepak KK

    更新日期:2021-03-01 00:00:00

  • Using a high-fidelity patient simulator with first-year medical students to facilitate learning of cardiovascular function curves.

    abstract::Students are relying on technology for learning more than ever, and educators need to adapt to facilitate student learning. High-fidelity patient simulators (HFPS) are usually reserved for the clinical years of medical education and are geared to improve clinical decision skills, teamwork, and patient safety. Finding ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00058.2012

    authors: Harris DM,Ryan K,Rabuck C

    更新日期:2012-09-01 00:00:00

  • The K-INBRE symposium: a 10-institution collaboration to improve undergraduate education.

    abstract::The Kansas-IDeA Network of Biomedical Research Excellence (K-INBRE) is an infrastructure-building program funded by the National Institute of General Medical Sciences. Undergraduate education, through undergraduate research, is a key component of the program. The K-INBRE network includes 10 higher education institutio...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00093.2017

    authors: Velasquez SE,Abraham K,Burnett TG,Chapin B,Hendry WJ 3rd,Leung S,Madden ME,Rider V,Stanford JA,Ward RE,Chapes SK

    更新日期:2018-03-01 00:00:00

  • Students' colleges and achievement in an advanced course.

    abstract::The aim of the present study was to determine whether a significant relationship exists between a student's college (Allied Health, Arts and Science, Education, and Graduate School) and achievement in an advanced-level course in human physiology (PGY 412G). The mean percentage of correct answers on four multiple-choic...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00039.2001

    authors: Zolman JF,Ott CE

    更新日期:2002-12-01 00:00:00

  • Conceptual assessment in the biological sciences: a National Science Foundation-sponsored workshop.

    abstract::Twenty-one biology teachers from a variety of disciplines (genetics, ecology, physiology, biochemistry, etc.) met at the University of Colorado to begin discussions about approaches to assessing students' conceptual understanding of biology. We considered what is meant by a "concept" in biology, what the important bio...

    journal_title:Advances in physiology education

    pub_type:

    doi:10.1152/advan.00047.2007

    authors: Michael J

    更新日期:2007-12-01 00:00:00

  • An active learning mammalian skeletal muscle lab demonstrating contractile and kinetic properties of fast- and slow-twitch muscle.

    abstract::The fact that humans possess fast- and slow-twitch muscle in the ratio of ∼50% has profound implications for designing exercise training strategies for power and endurance activities. With the growth of exercise and sport science courses, we have seen the need to develop an undergraduate student laboratory that demons...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00155.2012

    authors: Head SI,Arber MB

    更新日期:2013-12-01 00:00:00

  • Quantitative concept mapping in pulmonary physiology: comparison of student and faculty knowledge structures.

    abstract::Quantitative concept mapping, in contrast with qualitative approaches, is rigorous scientifically and permits statistical analyses of data about concept learning. This study extends past quantitative research on the structure of student concept learning in pulmonary physiology. Pathfinder scaling is used to derive con...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advances.2000.23.1.S72

    authors: McGaghie WC,McCrimmon DR,Mitchell G,Thompson JA,Ravitch MM

    更新日期:2000-06-01 00:00:00

  • Comparative effectiveness of a mnemonic-use approach vs. self-study to interpret a lateral chest X-ray.

    abstract::The chest X-ray is the most commonly performed medical imaging study; however, the lateral chest film intimidates many physicians and medical students. The lateral view is more difficult to interpret than the frontal view but provides important information that is either not visible or not as evident on frontal view, ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/advan.00034.2017

    authors: Thompson M,Johansen D,Stoner R,Jarstad A,Sorrells R,McCarroll ML,Justice W

    更新日期:2017-12-01 00:00:00

  • 2nd Pan American Congress of Physiological Sciences, Havana, Cuba, May 27-31, 2019.

    abstract::Physiology education was well represented at the 2nd Pan American Congress of Physiological Sciences in Havana, Cuba, with two symposia, a workshop, and a poster session. ...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00084.2019

    authors: Carroll RG,Halpin PA,Silverthorn DU

    更新日期:2019-09-01 00:00:00

  • Using manipulatives to improve learning in the undergraduate neurophysiology curriculum.

    abstract::Educational research has demonstrated that the use of concrete objects or manipulatives in the classroom enhances problem-solving skills and conceptual learning. This project examines the use of manipulatives in a neurophysiology curriculum and assesses their effectiveness on student comprehension. Three activities, b...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00042.2002

    authors: Krontiris-Litowitz J

    更新日期:2003-12-01 00:00:00

  • Too much content, not enough thinking, and too little fun!

    abstract::Teachers often overrate the importance of their content and underrate their influence. However, students forget much of the content that they memorize. Thus, attempts to teach students all that they will need to know is futile. Rather, it is important that students develop an interest and love for lifelong learning. I...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00075.2009

    authors: DiCarlo SE

    更新日期:2009-12-01 00:00:00

  • Online quizzes promote inconsistent improvements on in-class test performance in introductory anatomy and physiology.

    abstract::Review quizzes can provide students with feedback and assist in the preparation for in-class tests, but students often do not voluntarily use self-testing resources. The purpose of the present study was to evaluate if taking a mandatory online review quiz alters performance on subsequent in-class tests. During two sem...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00064.2014

    authors: Brown GA,Bice MR,Shaw BS,Shaw I

    更新日期:2015-06-01 00:00:00

  • Teaching basic gastrointestinal physiology using classic papers by Dr. Walter B. Cannon.

    abstract::The movements of the gastrointestinal tract, as described by Walter B. Cannon 100 years ago, reveal much about the functions of this unique organ and how it is controlled by the body. Two classic papers by Cannon provide a rare glimpse into the hidden functions of the body and give students a great example of the scie...

    journal_title:Advances in physiology education

    pub_type: 传,历史文章,杂志文章

    doi:10.1152/advan.00112.2006

    authors: Bertrand PP,Bertrand RL

    更新日期:2007-06-01 00:00:00

  • A simple ballistocardiographic system for a medical cardiovascular physiology course.

    abstract::Ballistocardiography is an old, noninvasive technique used to record the movements of the body synchronous with the heartbeat due to left ventricular pump activity. Despite the fact that this technique to measure cardiac output has been superseded by more advanced and precise techniques, it is useful for teaching card...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00025.2002

    authors: Eblen-Zajjur A

    更新日期:2003-12-01 00:00:00

  • Use of an iPad App to simulate pressure-volume loops and cardiovascular physiology.

    abstract::The purpose of this laboratory exercise is to model the changes in preload, afterload, and contractility on a simulated pressure-volume loop and to correlate those findings with common measurements of clinical cardiovascular physiology. Once students have modeled these changes on a healthy heart, the students are aske...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00204.2016

    authors: Leisman S,Burkhoff D

    更新日期:2017-09-01 00:00:00

  • Women in (neuro)science: report of a meeting held at the University of Valencia, Spain, in February 2018.

    abstract::February 11th is the International Day of Women and Girls in Science. To mark this day, research centers and universities were invited by the Spanish Neuroscience Association to organize a symposium. Twenty-five centers in Spain participated in the event, with the intent of giving visibility to the existing problem of...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.00113.2018

    authors: Mello-Carpes PB,Lloret A

    更新日期:2018-12-01 00:00:00

  • Teaching neurophysiology, neuropharmacology, and experimental design using animal models of psychiatric and neurological disorders.

    abstract::Animal models have been widely used for studying the physiology and pharmacology of psychiatric and neurological diseases. The concepts of face, construct, and predictive validity are used as indicators to estimate the extent to which the animal model mimics the disease. Currently, we used these three concepts to desi...

    journal_title:Advances in physiology education

    pub_type: 杂志文章

    doi:10.1152/advan.90179.2008

    authors: Morsink MC,Dukers DF

    更新日期:2009-03-01 00:00:00

  • Degree requirements of physiology undergraduate programs in the Physiology Majors Interest Group.

    abstract::Physiology undergraduate degree programs operate in isolation relative to other biological science programs, with little to no understanding of how other institutions structure their course requirements and other degree requirements. The purpose of this report is to preliminarily describe the collective curriculum of ...

    journal_title:Advances in physiology education

    pub_type: 社论

    doi:10.1152/advan.00179.2019

    authors: Wehrwein EA,VanRyn VS,Kelly K

    更新日期:2020-12-01 00:00:00

  • Teaching baroreflex physiology to medical students: a comparison of quiz-based and conventional teaching strategies in a laboratory exercise.

    abstract::Quiz-based and collaborative teaching strategies have previously been found to be efficient for the improving meaningful learning of physiology during lectures. These approaches have, however, not been investigated during laboratory exercises. In the present study, we compared the impact of solving quizzes individuall...

    journal_title:Advances in physiology education

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/advan.00011.2012

    authors: Berg RM,Plovsing RR,Damgaard M

    更新日期:2012-06-01 00:00:00