Abstract:
:We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.
journal_name
Genome Bioljournal_title
Genome biologyauthors
McGary KL,Lee I,Marcotte EMdoi
10.1186/gb-2007-8-12-r258subject
Has Abstractpub_date
2007-01-01 00:00:00pages
R258issue
12eissn
1474-7596issn
1474-760Xpii
gb-2007-8-12-r258journal_volume
8pub_type
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