Abstract:
:Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Vergara Z,Gutierrez Cdoi
10.1186/s13059-017-1236-9subject
Has Abstractpub_date
2017-05-23 00:00:00pages
96issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-017-1236-9journal_volume
18pub_type
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