Abstract:
:The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Zhao Z,Shilatifard Adoi
10.1186/s13059-019-1870-5subject
Has Abstractpub_date
2019-11-20 00:00:00pages
245issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-019-1870-5journal_volume
20pub_type
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