Abstract:
:PIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known for their function in silencing transposons and germline development by partnering with small noncoding RNAs called PIWI-interacting RNAs (piRNAs). However, recent studies have revealed multifaceted roles of the PIWI-piRNA pathway in regulating the expression of other major classes of RNAs in germ cells. In this review, we summarize how PIWI proteins and piRNAs regulate the expression of many disparate RNAs, describing a highly complex global genomic regulatory relationship at the RNA level through which piRNAs functionally connect all major constituents of the genome in the germline.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Wang C,Lin Hdoi
10.1186/s13059-020-02221-xsubject
Has Abstractpub_date
2021-01-08 00:00:00pages
27issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-020-02221-xjournal_volume
22pub_type
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