Abstract:
BACKGROUND:Gene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by feedback or buffering in expression networks. RESULTS:We profiled expression in engineered flies where gene dose was reduced from two to one. While expression of most one-dose genes was reduced, the gene-specific dose responses were heterogeneous. Expression of two-dose genes that are first-degree neighbors of one-dose genes in novel network models also changed, and the directionality of change depended on the response of one-dose genes. CONCLUSIONS:Our data indicate that expression perturbation propagates in network space. Autosomal compensation, or the lack thereof, is a gene-specific response, largely mediated by interactions with the rest of the transcriptome.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Malone JH,Cho DY,Mattiuzzo NR,Artieri CG,Jiang L,Dale RK,Smith HE,McDaniel J,Munro S,Salit M,Andrews J,Przytycka TM,Oliver Bdoi
10.1186/gb-2012-13-4-r28subject
Has Abstractpub_date
2012-04-24 00:00:00pages
r28issue
4eissn
1474-7596issn
1474-760Xpii
gb-2012-13-4-r28journal_volume
13pub_type
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