Abstract:
:Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers from clinical array comparative genomic hybridization data. The tumor cell fraction is reliably estimated in the model. Data consistent with FISH results are achieved. We demonstrate significant improvements over existing methods for exploring gene dosages and intratumor copy number heterogeneity in cancers.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Lyng H,Lando M,Brøvig RS,Svendsrud DH,Johansen M,Galteland E,Brustugun OT,Meza-Zepeda LA,Myklebost O,Kristensen GB,Hovig E,Stokke Tdoi
10.1186/gb-2008-9-5-r86subject
Has Abstractpub_date
2008-01-01 00:00:00pages
R86issue
5eissn
1474-7596issn
1474-760Xpii
gb-2008-9-5-r86journal_volume
9pub_type
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