Abstract:
:Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. In eukaryotes, sirtuins regulate transcriptional repression, recombination, the cell-division cycle, microtubule organization, and cellular responses to DNA-damaging agents. Sirtuins have also been implicated in regulating the molecular mechanisms of aging. The Sir2 catalytic domain, which is shared among all sirtuins, consists of two distinct domains that bind NAD and the acetyl-lysine substrate, respectively. In addition to the catalytic domain, eukaryotic sirtuins contain variable amino- and carboxy-terminal extensions that regulate their subcellular localizations and catalytic activity.
journal_name
Genome Bioljournal_title
Genome biologyauthors
North BJ,Verdin Edoi
10.1186/gb-2004-5-5-224keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
224issue
5eissn
1474-7596issn
1474-760Xpii
gb-2004-5-5-224journal_volume
5pub_type
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