Abstract:
:A recent study in Genome Biology has characterized the evolution of candidate hominoid-specific liver enhancers by using massively parallel reporter assays (MPRAs).
journal_name
Genome Bioljournal_title
Genome biologyauthors
Kwon SB,Ernst Jdoi
10.1186/s13059-018-1502-5subject
Has Abstractpub_date
2018-08-14 00:00:00pages
114issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-018-1502-5journal_volume
19pub_type
杂志文章相关文献
GENOME BIOLOGY文献大全abstract::A new study shows that genomic introgression between two Heliconius butterfly species is not solely confined to color pattern loci. ...
journal_title:Genome biology
pub_type: 评论,杂志文章
doi:10.1186/s13059-016-0898-z
更新日期:2016-02-27 00:00:00
abstract::Key components of the programmed cell death pathway are conserved between Caenorhabditis elegans, Drosophila melanogaster and humans. The search for additional homologs has been facilitated by the availability of the entire genomic sequence for each of these organisms. ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2000-1-3-reviews0003
更新日期:2000-01-01 00:00:00
abstract::We present a new method, Fine-Mapping of Adaptive Variation (FineMAV), which combines population differentiation, derived allele frequency, and molecular functionality to prioritize positively selected candidate variants for functional follow-up. We calibrate and test FineMAV using eight experimentally validated "gold...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-017-1380-2
更新日期:2018-01-17 00:00:00
abstract:BACKGROUND:The vast number of precise intercellular connections within vertebrate nervous systems is only partly explained by the comparatively few known extracellular guidance cues. Large families of neural orphan receptor proteins have been identified and are likely to contribute to these recognition processes but du...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2009-10-9-r99
更新日期:2009-01-01 00:00:00
abstract::As the cost of sequencing continues to decrease and the amount of sequence data generated grows, new paradigms for data storage and analysis are increasingly important. The relative scaling behavior of these evolving technologies will impact genomics research moving forward. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-016-0917-0
更新日期:2016-03-23 00:00:00
abstract:BACKGROUND:Bread wheat is one of the most important and broadly studied crops. However, due to the complexity of its genome and incomplete genome collection of wild populations, the bread wheat genome landscape and domestication history remain elusive. RESULTS:By investigating the whole-genome resequencing data of 93 ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-019-1744-x
更新日期:2019-07-12 00:00:00
abstract::Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2011-12-4-109
更新日期:2011-01-01 00:00:00
abstract::A report on the Cold Spring Harbor Laboratory/Wellcome Trust conference on Network Biology, Hinxton, UK, 27-31 August 2008. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb-2008-9-10-324
更新日期:2008-10-27 00:00:00
abstract:BACKGROUND:Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here, we investigate whether a sub-set of triacylglycerols (TAGs) were associated w...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-018-1439-8
更新日期:2018-06-20 00:00:00
abstract::A new generation of DNA-sequencing platforms will become commercially available over the next few years. These instruments will enable re-sequencing of human genomes at a previously unimagined throughput and low cost. Here, I examine why the 1,000 dollar human genome is an important goal for research and clinical diag...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2006-7-7-112
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:It has been hypothesized that rapid divergence in centromere sequences accompanies rapid karyotypic change during speciation. However, the reuse of breakpoints coincident with centromeres in the evolution of divergent karyotypes poses a potential paradox. In distantly related species where the same centromer...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r170
更新日期:2007-01-01 00:00:00
abstract::The yeast Saccharomyces cerevisiae shows a great variety of cellular responses to glucose via several glucose-sensing and signaling pathways. Recent microarray analysis has revealed multiple levels of genomic sensitivity to glucose and highlighted the power of genome-wide analysis to detect cellular responses to minut...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2003-4-11-233
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The functional impact of genetic variation has been extensively surveyed, revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic regions. Studies have linked allele-specific genetic changes to gene expression, DNA methylation, and histone marks but these investigations have ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-017-1173-7
更新日期:2017-03-10 00:00:00
abstract::A new approach to rapid, genome-wide identification and ranking of horizontal transfer candidate proteins is presented. The method is quantitative, reproducible, and computationally undemanding. It can be combined with genomic signature and/or phylogenetic tree-building procedures to improve accuracy and efficiency. T...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-2-r16
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Human tissue is increasingly being whole genome sequenced as we transition into an era of genomic medicine. With this arises the potential to detect sequences originating from microorganisms, including pathogens amid the plethora of human sequencing reads. In cancer research, the tumorigenic ability of patho...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-019-1819-8
更新日期:2019-10-22 00:00:00
abstract::Two recent studies demonstrate the power of integrating tumor genotype information with epigenetic and proteomic studies to discover potential therapeutic targets in breast cancer. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-017-1238-7
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:Methods of microarray analysis that suit experimentalists using the technology are vital. Many methodologies discard the quantitative results inherent in cDNA microarray comparisons or cannot be flexibly applied to multifactorial experimental design. Here we present a flexible, quantitative Bayesian framewor...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2002-3-12-research0071
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In the mouse, it is encoded by ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-019-1633-3
更新日期:2019-01-31 00:00:00
abstract::Field pathogenomics adds highly informative data to surveillance surveys by enabling rapid evaluation of pathogen variability, population structure and host genotype. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-015-0615-3
更新日期:2015-03-02 00:00:00
abstract:BACKGROUND:Obligate pathogenic bacteria lose more genes relative to facultative pathogens, which, in turn, lose more genes than free-living bacteria. It was suggested that the increased gene loss in obligate pathogens may be due to a reduction in the effectiveness of purifying selection. Less attention has been given t...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r164
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolut...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2002-3-2-research0008
更新日期:2002-01-01 00:00:00
abstract::A recent study explores the genome content of uncultured unicellular marine eukaryotes and provides insights about interactions between uncultured eukaryotes and other biological entities. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2011-12-6-117
更新日期:2011-06-27 00:00:00
abstract::Rhomboid proteases are the largest family of enzymes that hydrolyze peptide bonds within the cell membrane. Although discovered to be serine proteases only a decade ago, rhomboid proteases are already considered to be the best understood intramembrane proteases. The presence of rhomboid proteins in all domains of life...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2011-12-10-231
更新日期:2011-10-27 00:00:00
abstract:BACKGROUND:The influence of genetic variation on complex diseases is potentially mediated through a range of highly dynamic epigenetic processes exhibiting temporal variation during development and later life. Here we present a catalogue of the genetic influences on DNA methylation (methylation quantitative trait loci ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-016-0926-z
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Although genetic or epigenetic alterations have been shown to affect the three-dimensional organization of genomes, the utility of chromatin conformation in the classification of human disease has never been addressed. RESULTS:Here, we explore whether chromatin conformation can be used to classify human leu...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-4-r60
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures-each representing a mutagenic process-derived from 3056 patients spanning 19 cancer types to quantify the strand asymmetry of mutational ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-018-1509-y
更新日期:2018-09-10 00:00:00
abstract::Genome editing holds remarkable promise to transform human medicine as new therapies that can directly address the genetic causes of disease. However, concerns remain about possible undesired biological consequences of genome editors, particularly the introduction of unintended 'off-target' mutations. Here, we discuss...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-018-1610-2
更新日期:2018-12-22 00:00:00
abstract::A report on the 18th Congress of the European Society for Evolutionary Biology (ESEB), Aarhus, Denmark, 20-25 August, 2001. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb-2001-2-11-reports4026
更新日期:2001-01-01 00:00:00
abstract::Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a structure-based framework, Coev2Net, for computing a single confidence score that addresses both false-p...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2012-13-8-r76
更新日期:2012-08-31 00:00:00
abstract::Ancient DNA research is revealing a human history far more complex than that inferred from parsimonious models based on modern DNA. Here, we review some of the key events in the peopling of the world in the light of the findings of work on ancient DNA. ...
journal_title:Genome biology
pub_type: 历史文章,杂志文章,评审
doi:10.1186/s13059-015-0866-z
更新日期:2016-01-11 00:00:00