Abstract:
:We introduce ABLE (Approximate Blockwise Likelihood Estimation), a novel simulation-based composite likelihood method that uses the blockwise site frequency spectrum to jointly infer past demography and recombination. ABLE is explicitly designed for a wide variety of data from unphased diploid genomes to genome-wide multi-locus data (for example, RADSeq) and can also accommodate arbitrarily large samples. We use simulations to demonstrate the accuracy of this method to infer complex histories of divergence and gene flow and reanalyze whole genome data from two species of orangutan. ABLE is available for download at https://github.com/champost/ABLE .
journal_name
Genome Bioljournal_title
Genome biologyauthors
Beeravolu CR,Hickerson MJ,Frantz LAF,Lohse Kdoi
10.1186/s13059-018-1517-ysubject
Has Abstractpub_date
2018-09-25 00:00:00pages
145issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-018-1517-yjournal_volume
19pub_type
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