Residual platelet reactivity is an independent predictor of myocardial injury in acute myocardial infarction patients on antiaggregant therapy.

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:We have investigated the role of two vasoactive substances, nitric oxide (NO)and endothelin (ET), in the pathophysiology of disseminated intravascular coagulation (DIC), using two types of DIC models. Experimental DIC was induced by sustained infusion of 0.1, 1, 10, or 50 mg/kg lipopolysaccharide (LPS), or 3.75 U/kg t...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Okudaira M,Yoshida T,Ontachi Y,Yamazaki M,Morishita E,Miyamoto K,Nakao S

更新日期：2002-10-01 00:00:00

abstract：:Hemin is a heme oxygenase-1 (HO-1) inducer which provides endogenous carbon monoxide known for playing roles in cell proliferation, inflammation or aggregation process. The objective of the current study was to examine the effect of prophylactic treatment with hemin in a thrombosis vascular model. Three groups of Wist...

journal_title：Thrombosis and haemostasis

authors： Desbuards N,Rochefort GY,Schlecht D,Machet MC,Halimi JM,Eder V,Hyvelin JM,Antier D

更新日期：2007-09-01 00:00:00

abstract：:In this study, we investigate the influence of three factor VII (FVII) gene polymorphisms on activated FVII levels (FVIIa), and also on the risk of myocardial infarction (MI) in patients with advanced coronary atherosclerotic disease (CAD). The -323A2 allele in the promoter is known to be associated with low FVII leve...

journal_title：Thrombosis and haemostasis

authors： Bozzini C,Girelli D,Bernardi F,Ferraresi P,Olivieri O,Pinotti M,Martinelli N,Manzato F,Friso S,Villa G,Pizzolo F,Beltrame F,Corrocher R

更新日期：2004-09-01 00:00:00

abstract：:Antibodies directed against ADAMTS13 have been detected in the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP). We have previously localized a major antigenic determinant within the spacer domain of ADAMTS13. To identify the amino acid residues of the spacer domain that are involved in bin...

journal_title：Thrombosis and haemostasis

authors： Luken BM,Turenhout EA,Kaijen PH,Greuter MJ,Pos W,van Mourik JA,Fijnheer R,Voorberg J

更新日期：2006-09-01 00:00:00

abstract：:The influence of the sympathetic nervous system on platelet functions in vivo is still controversial. The aims of our study were to compare the response to various sympathetic stimuli in normal subjects and in patients with essential hypertension (HT) or peripheral vascular disease (PVD) and to evaluate any correlatio...

journal_title：Thrombosis and haemostasis

authors： Catalano M,Russo U,Belletti S,Colombo F,Belloni A,del Rosso G,Lombardi F,Libretti A

更新日期：1990-06-28 00:00:00

abstract：:A group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 pat...

journal_title：Thrombosis and haemostasis

authors： Stain C,Pabinger-Fasching I,Guggenberger K,Köller U,Stain M,Hartl H,Heinz F,Mayerhofer S,Kyrle PA,Lechner K

更新日期：1989-06-30 00:00:00

abstract：:Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to...

journal_title：Thrombosis and haemostasis

authors： Goon PK,Boos CJ,Stonelake PS,Blann AD,Lip GY

更新日期：2006-07-01 00:00:00

abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

journal_title：Thrombosis and haemostasis

authors： Bakhshi MR,Kirby EP

更新日期：1990-06-28 00:00:00

abstract：:We compared the Ivy bleeding time method and two alternatives of the Simplate II method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-...

journal_title：Thrombosis and haemostasis

authors： Srámek R,Srámek A,Koster T,Briët E,Rosendaal FR

更新日期：1992-05-04 00:00:00

abstract：:Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

journal_title：Thrombosis and haemostasis

authors： Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

更新日期：2018-06-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:Desmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA re...

journal_title：Thrombosis and haemostasis

authors： Grant MB,Guay C,Lottenberg R

更新日期：1988-04-08 00:00:00

abstract：:The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

journal_title：Thrombosis and haemostasis

authors： Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

更新日期：2015-03-01 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:The endocannabinoid anandamide (AEA) has many neurovascular activities. However, it is not yet clear how AEA can be metabolized at the neurovascular interface, and how it can move through the vascular and the cerebral compartments. The results reported in this article show that isolated bovine brain microvessels, an e...

journal_title：Thrombosis and haemostasis

authors： Maccarrone M,Fiori A,Bari M,Granata F,Gasperi V,De Stefano ME,Finazzi-Agrò A,Strom R

更新日期：2006-01-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

journal_title：Thrombosis and haemostasis

authors： Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

更新日期：2021-01-05 00:00:00

abstract：:Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

journal_title：Thrombosis and haemostasis

authors： Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

更新日期：2017-10-05 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:Human antithrombin III was purified from fresh human plasma by affinity chromatography on heparin-Sepharose, affinity chromatography on concanavalin A Sepharose, gel filtration on Ultrogel AcA 34, ion exchange chromatography on DEAE A-50 Sephadex and preparative agarose gel electrophoresis. The hydrolytic activity of ...

journal_title：Thrombosis and haemostasis

authors： Clemmensen I

更新日期：1978-06-30 00:00:00

abstract：:A simple collagen binding assay (CBA) for measuring activity of the von Willebrand factor cleaving protease in clinical samples is described, and results of fifty masked plasmapheresis samples rom patients with TTP/HUS and other diseases are presented. There was 97.5% concordance between the CBA and a multimer gel ass...

journal_title：Thrombosis and haemostasis

authors： Rick ME,Moll S,Taylor MA,Krizek DM,White GC 2nd,Aronson DL

更新日期：2002-10-01 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

journal_title：Thrombosis and haemostasis

authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

更新日期：1999-09-01 00:00:00

abstract：:Accurate and precise measurement of plasma D-dimer levels is important in the diagnosis and management of venous thromboembolism. Considerable variability in D-dimer results obtained using different methods has, however, been reported in multicentre studies. This study explored in two separate multicentre exercises th...

journal_title：Thrombosis and haemostasis

authors： Jennings I,Woods TA,Kitchen DP,Kitchen S,Walker ID

更新日期：2007-11-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced levels of PAI-1 are related to pathological conditions associated with hypoxia or hyperinsulinemia. In this study, we investigated the...

journal_title：Thrombosis and haemostasis

authors： Dimova EY,Jakubowska MM,Kietzmann T

更新日期：2007-08-01 00:00:00

abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

journal_title：Thrombosis and haemostasis

authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

更新日期：2011-12-01 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Platelet aggregation and adenine nucleotides in platelets have been studied in thirteen patients with myeloproliferative disorders. ADP induced aggregation was abnormal in two patients, but collagen induced aggregation was impaired in 11 patients. The concentrations of ATP and ADP in resting platelets in the patients ...

journal_title：Thrombosis and haemostasis

authors： Nishimura J,Okamoto S,Ibayashi H

更新日期：1979-06-30 00:00:00