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Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells.

Abstract：

:The endocannabinoid anandamide (AEA) has many neurovascular activities. However, it is not yet clear how AEA can be metabolized at the neurovascular interface, and how it can move through the vascular and the cerebral compartments. The results reported in this article show that isolated bovine brain microvessels, an ex vivo model of the blood-brain barrier, have detectable levels of endogenous AEA and possess the biochemical machinery to bind and metabolize it, i.e. type-1 and type-2 cannabinoid receptors (CB1R and CB2R), a selective AEA membrane transporter (AMT), an AEA-degrading fatty acid amide hydrolase, and the AEA-synthesizing enzymes N-acyltransferase and N-acyl-phosphatidylethanolamines-specific phospholipase D. We also show that activation of CB1R enhances AMT activity through increased nitric oxide synthase (NOS) activity and subsequent increase of NO production. AMT activity is instead reduced by activation of CB2R, which inhibits NOS and NO release. In addition, binding experiments and immunoelectronmicroscopy demonstrate that different endothelial cells vary in the expression of CB1R and CB2R on the luminal and/or abluminal sides. The different localization of CBRs can lead to a diverse effect on AMT activity on the luminal and abluminal membranes, suggesting that the distribution of these receptors may drive AEA directional transport through the blood-brain barrier and other endothelial cells.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Maccarrone M,Fiori A,Bari M,Granata F,Gasperi V,De Stefano ME,Finazzi-Agrò A,Strom R

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

117-27

issue

1

eissn

0340-6245

issn

2567-689X

pii

06010117

journal_volume

95

pub_type

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