Abstract：
:Alteration of the epigenome is associated with a wide range of human diseases. Therefore, deciphering the pathways that regulate the epigenetic modulation of gene expression is a major milestone for the understanding of diverse biological mechanisms and subsequently human pathologies. Although often evoked, little is known on the implication of telomeric position effect, a silencing mechanism combining telomere architecture and classical heterochromatin features, in human cells. Nevertheless, this particular silencing mechanism has been investigated in different organisms and several ingredients are likely conserved during evolution. Subtelomeres are highly dynamic regions near the end of the chromosomes that are prone to recombination and may buffer or facilitate the spreading of silencing that emanates from the telomere. Therefore, the composition and integrity of these regions also concur to the propensity of telomeres to regulate the expression, replication and recombination of adjacent regions. Here we describe the similarities and disparities that exist among the different species at chromosome ends with regard to telomeric silencing regulation with a special accent on its implication in numerous human pathologies.
journal_name
Biochimiejournal_title
Biochimieauthors
Ottaviani A,Gilson E,Magdinier Fdoi
10.1016/j.biochi.2007.07.022subject
Has Abstractpub_date
2008-01-01 00:00:00pages
93-107issue
1eissn
0300-9084issn
1638-6183pii
S0300-9084(07)00198-8journal_volume
90pub_type
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